One of the critical roles of clinical pharmacists in daily practices in hospitals is to assure safety and quality of injectable infusions administered to critically ill patients who suffer from calorie deficit and require parenteral nutrition admixtures. These infusions contains different nutrients and other components in variable ratios. Sometimes, (PN) need to be administered with drugs for dual therapy in specific cases like in case of infections and malnutrition. Stability studies and compatibility tests should be done prior to administration to assure safety and avoidance of medication errors events. Ciprofloxacin (CF) as an antibacterial agent usually used for management of moderate-to-severe gram positive and gram negative infections.

References

1. Gostyńska A., et al. “The interactions between ciprofloxacin and parenteral nutrition admixtures”. Pharmaceutics 12.1 (2020).
2. Richard L Elmore., et al. “Stability and Compatibility of Admixtures of Intravenous Ciprofloxacin and Selected Drugs”. Clinical Therapeutics 18.2 (1996): 246-255.
3. DM Campoli-Richards, et al. “Ciprofloxacin. A Review of Its Antibacterial Activity, Pharmacokinetic Properties and Therapeutic Use”. Drugs 35.4 (1988): 373-447.
4. LA Percy and JP Rho. “Visual Compatibility of Ciprofloxacin With Selected Components of Total Parenteral Nutrient Solutions During Simulated Y-site Injection”. American Journal of Health-System Pharmacy 50.4 (1993): 715-716.

Citation

Citation: Marwa EL-Sayed. “Ciprofloxacin and Total Parenteral Nutrition (TPN) Solutions Incompatibility". Acta Scientific Pharmacology 1.4 (2020): 23.

Copyright

Copyright: © 2020 Marwa EL-Sayed. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.