Abstract

  Metabolic diseases like hypertension, excess weight, obesity, type-2 diabetes, and vascular diseases have increased in prevalence and incidence rapidly, to epidemic proportions worldwide. Studies from several laboratories, have demonstrated altered vascular flow, development of endothelial dysfunction, hardening of the arteries, and subclinical atherosclerosis as the earliest signs of vascular disease. In our efforts to find noninvasive diagnostic tools, to detect metabolic risks we have been testing emerging technologies, including activity trackers like Fitbit, Apple watch, thermal imaging, AGE-Reader (www.diagnoptics.com), as well as several LD-Technology products. We have validated several of their products, for monitoring metabolic risks such as blood pressure, impaired glucose tolerance, lipid abnormalities, insulin resistance, cardiac functions, autonomous risk, sympathetic risk, endothelial dysfunction, and for computing wellness index. In an earlier article we described the use of wellness screening in determining the benefits of structured wellness training on cardiometabolic risks and wellness index. In this study, we have evaluated the effect of transdermal delivery of phytochemical on autonomous nervous system score, vascular function score, and wellness index. Commercially available rejuvenation oil, applied on the skin, showed significant improvement in autonomous nervous score, vascular function score, as well as overall wellness index. We would like to include several other noninvasive technologies for conducting a battery of tests, to improve early diagnosis of metabolic risks, as well as better management of the observed risks, and to follow the progression of these cardiometabolic risks and their regression.

Keywords: Hypertension; Obesity; Type-2 Diabetes; Metabolic Diseases

References

1. Abott A. “Trial hints at age clock reversal”. Nature 573 (2019): 173.
2. Fahy GM., et al. “Reversal of epigenetic aging and immunosenescent trends in humans”. Aging Cell 18.6 (2019).
3. BabizhaYev MA., et al. “The role of oxidative stress in diabetic neuropathy: Generation of free radical species in the glycation reaction and gene polymorphisms encoding antioxidant enzymes to genetic susceptibility to diabetic neuropathy in population of type-1 diabetic patients”. Cell Biochemistry and Biophysics 71.3 (2015): 1425-1443.
4. Osawa T and Kato Y. “Protective role of antioxidative food factors in oxidative stress cause by hyperglycemia”. Annals of the New York Academy of Sciences 1043 (2005): 440-451.
5. Fiorentino TV., et al. “Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases”. Current Pharmaceutical Design 19.32 (2013): 5693-5703.
6. Ma X., et al. “The pathogenesis of diabetes mellitus by oxidative stress and inflammation: its inhibition by Berberine”. Frontier Pharmacology 9 (2018): 782.
7. Hybertson BM., et al. “Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation”. Molecular Aspects of Medicine 32 (2011): 234-246.
8. Joe M McCord and Fridovich I. “The biology and pathology of oxygen radicals”. Annals of Internal Medicine 89.1 (1978): 122-127. 
9. Rao GHR. “Cardiometabolic Diseases: A global perspective”. Journal of Cardiology and Cardiovascular Therapy 12 (2018).
10. Cheng Y., et al. “Tie trend of cardiometabolic risk factors over a 10-year period in the office- working population in China”. BMJ Open 9.5 (5): e025915.
11. NCD Risk Factor Collaboration (NCD-RisC). “Trends in cardiometabolic risk factors in the Americas between 1980 and 2014: a pooled analysis of population-based surveys”. Lancet Global Health 8.1 (2020): PE123-133.
12. Rao GHR. “Prevention or Reversal of Cardiometabolic Risk in India”. Journal of Clinical and Preventive Cardiology 7.1 (2018): 22-28.
13. Gandhi PG and Rao GHR. “The spectral analysis of photoplethysmography to evaluate an independent cardiovascular risk factor”. International Journal of General Medicine 7 (2014): 539-547.
14. Gandhi PG and Rao GHR. “Detection of neuropathy using a SudoMotor test in type-2 diabetes”. Degenerative Neurological and neuromuscular Disease 5 (2015): 1-7.
15. Knox M., et al. “A review of endothelium-dependent and independent vasodilation induce by phytochemicals in isolated rat aorta”. Animals (Basel) 9.9 (2018): 623.
16. Abeywardena M., et al. “Polyphenol-enriched extract of oil palm fronds (Elaeis guneensis) promotes vascular relaxation via endothelium-dependent mechanisms”. Asia Pacific Journal of Clinical Nutrition 11 (2002): S467-S472.
17. Kwan CY., et al. “Endothelium dependent vasorelaxation effects of the aqueous extracts of the Eucommia ulmoides Oliv. Leaf and bark: Implications on their antihypertensive action”. Vascular Pharmacology 40 (2003): 229-235.
18. Lee YJ., et al. “Extracts from Schizandra chinensis fruit activate estrogen receptors: A possible clue to its effects on nitric oxide-mediated vasorelaxation”. Biological and Pharmaceutical Bulletin 27 (2004): 1066-1069.
19. Kim EY., et al. “Cirsium japonicum elicits endothelium-dependent relaxation via histamine H (1) receptor in rat thoracic aorta”. Journal of Ethnopharmacology 116 (2008): 223-227.
20. Matsui T., et al. “Apple procyanidins induced vascular relaxation in isolated rat aorta through NO/cGMP pathway in combination with hyperpolarization by multiple K+ channel activations”. Bioscience, Biotechnology, and Biochemistry 73 (2009): 2246-2251.
21. Xia M., et al. “Endothelium-independent relaxation and contraction of rat aorta induced by ethyl acetate extract from eaves of Morus alba”. Journal of Ethnopharmacology 120 (2008): 442-446.
22. Kooshki A and Hoseni BL. “Phytochemicals and Hypertension”. Shiraz E-Medical Journal15.1 (2014): e19738.
23. Upadhyay S and Dixit M. “Role of Phytophenols and other phytochemicals on molecular signalling”. Oxidative Med and Cellular Longevity (2015).
24. Gayathri Choda and Rao GHR. “Diabetes-related clinical complications: Novel Approaches for Diagnosis and Management”. Journal of Clinical Cardiology and Diagnosis 2 (2019): 1-8.
25. Gayathri Choda and Rao GHR. “Thermal Imaging for Early Diagnosis of Vascular Dysfunction: Case Report”. Journal of Clinical Cardiology and Diagnostics 2 (2019): 1-7.
26. Malmefeldt E and Rao GHR. “Noninvasive Diagnostic tools: Cardiometabolic Risk Assessment and Prediction”. Journal of Clinical Cardiology and Diagnostics 2 (2019): 1-10.
27. Malmefeldt E and Rao GHR. “Changing Concepts of Healthcare: Physical activity, Fitness and Wellness”. ECEMR 4 (2019): 238-250.
28. Rao GHR. “Integration of Emerging Technologies: Cardiometabolic Diseases”. Indian Journal of Cardio Biology and Clinical Sciences 5.1 (2018): 111.
29. Uzomba O and Rao GHR. “Management of diabetes and Cardiometabolic risks using a novel diagnostic platform”. Intervention in Obesity and Diabetes 2.3 (2018).
30. Rao GHR. “Integrative approach to the management of cardiometabolic diseases”. Journal of Cardiology and Cardiovascular Sciences 2 (2018): 37-42.
31. More SV., et al. “Advances in neuroprotective ingredients of medicinal herbs by using cellular and animal models of Parkinson’s Disease”. Review Article Evidence-based Complementary and Alternative Medicine (2013): 15.

Citation

Citation: Elena Malmefeldt and Gundu HR Rao. “Wellness Screening for Assessing Benefits of a Rejuvenating Oil”. Acta Scientific Pharmacology 1.2 (2020):37-43.

Copyright

Copyright: © 2020 Elena Malmefeldt and Gundu HR Rao. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.