Toxicity/carcinogenicity studies in rodents have played a pivotal role in identifying chemicals that are potentially hazardous to humans. In fact, nearly all of the known human carcinogens are also carcinogenic in 1 or more rodent species. During the past 20 years, the quality and consistency of rodent studies has improved considerably, and much has been learned about mechanisms whereby chemicals initiate or promote the carcinogenic process in rats and mice. The process of identifying chemicals that cause toxicity or carcinogenicity in rodents is quite well established. However, there has been lot of debate among learned and concerned scientists both in the regulatory and the regulated community with respect to extrapolating these data for risk management decisions in the protection of human health.

References

Citation

Citation: KS Rao. “Potential Sunset of 2-Year Carcinogenicity Studies in Rodents for Small Molecule Pharma Compounds”. Acta Scientific Pharmacology 1.3 (2020):12-13.

Copyright

Copyright: © 2020 KS Rao. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.