Sukriti Pruthi¹*, Surender Sharma², Amandeep Singh Dhaliwal¹, Nandish M¹ and Rushdhan Husnee Ageel¹

¹Junior Resident, Department of Psychiatry, Armed Forces Medical College, Pune, India
²Associate Professor, Department of Psychiatry, Command Hospital Southern Command, Pune, India

*Corresponding Author: Sukriti Pruthi, Junior Resident, Department of Psychiatry, Armed Forces Medical College, Pune, India.

Received: October 21, 2025; Published: November 11, 2025

Abstract

Multiple sclerosis (MS) is a chronic demyelinating disorder often accompanied by neuropsychiatric manifestations arising from fronto-limbic and prefrontal involvement. This case series describes four patients with long-standing MS who developed organic psychiatric syndromes independent of neurological relapse. Two patients presented with organic depressive disorder, one with organic anxiety disorder, and organic personality disorder. The MRI Brain scans of the cases revealed fronto-cingulate, orbitofrontal, or limbic demyelination, corresponding with the clinical features. They improved significantly with SSRI’s, mood stabilizers, and psychotherapy. The findings highlight that psychiatric symptoms in chronic MS often reflect direct neurobiological consequences of demyelination rather than reactive psychological distress, emphasizing the importance of integrated neuropsychiatric assessment in MS management for aiding better functional and holistic outcomes.

Keywords: Multiple Sclerosis; Organic Depressive Disorder; Organic Anxiety Disorder; Organic Personality Disorder

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Citation

Citation: Sukriti Pruthi., et al. “Unmasking the Mind-Organic Psychiatric Manifestations in Long-term Multiple Sclerosis: A Case Series".Acta Scientific Neurology 8.11 (2025): 09-13.

Copyright

Copyright: © 2025 Sukriti Pruthi., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.