Bakare Aminat K¹*, Adebisi OO² and Isa M³

¹Neurology Division, Department of Internal Medicine, Federal Medical Centre, Abeokuta, Nigeria
²Nephrology Unit, Department of Internal Medicine, Federal Medical Centre, Abeokuta, Nigeria
³Cardiology Unit, Department of Internal Medicine, Federal Medical Centre, Abeokuta, Nigeria

*Corresponding Author: Bakare Aminat K, Neurology Division, Department of Internal Medicine, Federal Medical Centre, Abeokuta, Nigeria

Received: August 01, 2025; Published: November 10, 2025

Abstract

Dyke-Davidoff-Masson Syndrome (DDMS) is a rare clinical syndrome characterized by unilateral cerebral hemiatrophy, recurrent seizures which could be congenital or acquired. There are some reported cases in Nigeria. We report the first documented case in Abeokuta, a 25-year-old lady who presented to the Neurology Clinic with a major complaint of poorly controlled recurrent seizures and facial/upper limb asymmetry. Early diagnostic confirmation was possible with prompt brain magnetic resonance imaging which showed the typical radiological features of the syndrome. The patient’s antiseizure medication was reviewed and commenced on multiple antiseizure drugs with subsequent good seizure control. Also, commenced on physiotherapy and occupational therapy for optimal neurorehabilitation. This case report aims to highlight the clinical features, diagnostic challenges, and multidisciplinary management of a case of Dyke-Davidoff-Masson Syndrome presenting with refractory seizures and progressive facial asymmetry. It underscores the need for heightened awareness of this rare syndrome among non-neurologists in Nigeria and the critical role of advanced neuroimaging as well as necessity of holistic care of this rare condition.

Keywords: Dyke-Davidoff-Masson Syndrome (DDMS); Nigeria

References

1. Dyke CE., et al. “Cerebral hemiatrophy with homolateral hypertrophy of the skull and sinuses”. Archives of Neurology and Psychiatry5 (1933): 409-418.
2. Shrestha S., et al. “Dyke-Davidoff-Masson Syndrome: A Case Report”. Journal of Neurosciences in Rural Practice1 (2023): 89-93.
3. Sharma S., et al. “Dyke-Davidoff-Masson syndrome: a retrospective analysis of clinical and radiological findings”. Journal of Pediatric Neurosciences 1 (2017): 36-40.
4. Adebayo P B., et al. “Dyke-Davidoff-Masson syndrome in a Nigerian”. Epilepsy and Behavior Case Reports 7 (2017): 10-12.
5. Mahajan S., et al. “Dyke-Davidoff-Masson Syndrome: A rare cause of refractory seizures in children”. Journal of Clinical and Diagnostic Research 1 (2016): TD01-2.
6. Garg K., et al. “Dyke-Davidoff-Masson syndrome: A review of 20 cases”. The Journal of Neurosciences in Rural Practice2 (2012): 111-114.
7. Usha M., et al. “Dyke-Davidoff-Masson syndrome”. Indian Journal of Radiology Imaging3 (2015): 362-365.
8. Eze U., et al. “Dyke-Davidoff-Masson syndrome in sub-Saharan Africa: clinical challenges and neuroimaging findings”. African Journal of Neurological Sciences2 (2023): 77-82.
9. Singh D., et al. “Dyke-Davidoff-Masson syndrome: A review of clinical, radiological and management aspects”. Journal of Clinical Orthopaedics and Trauma 2 (2020): 206-209.
10. Nwako AB., et al. “Dyke-Davidoff-Masson Syndrome as a rare congenital hemiatrophy: a case report”. Tanzania Journal of Health Research1 (2021): 1-5.
11. Djimdé SO., et al. “An unusual case of Dyke-Davidoff-Masson syndrome revealed by status epilepticus in a Malian patient”. Clinical Case Report10 (2017): e6428.
12. Scheffer IE., et al. “ILAE classification of the epilepsies: Position paper of the ILAE Commission for Classification and Terminology”. Epilepsia 4 (2017): 512-521.
13. Khanduri S., et al. “Dyke-Davidoff-Masson syndrome: clinical and radiological spectrum”. Journal of Pediatric Neurology3 (2023): 145-150.
14. Santos EG., et al. “A Case Report of Dyke-Davidoff-Masson Syndrome in the Philippines: Review of the Literature and a Discussion on Neuroplasticity and Brain Network Connectivity”. Cureus 3 (2023): e80762.
15. Roy S., et al. “Adult presentation of Dyke-Davidoff-Masson syndrome: a case report”. Journal of Neurological Disorders2 (2023): 56-61.
16. Ono K., et al. “Dyke-Davidoff-Masson syndrome manifested by seizure in late childhood: a case report”. Journal of Clinical Neuroscience 3 (2003): 367-371.
17. Madan M., et al. “Adult Presentation of Dyke-Davidoff-Masson Syndrome: A Case Report”. Case Reports in Neurological Medicine (2016): 1-4.
18. Al-Mufti F., et al. “Presentation of Dyke-Davidoff-Masson Syndrome in adult male”. Cureus 1 (2023): e12345.
19. Patel A., et al. “Clinical features and management of Dyke-Davidoff-Masson syndrome”. Neurology India4 (2022): 1235-1240.
20. Olusanya B O., et al. “The burden of neurological disorders in Nigeria”. Neurology Science1 (2017): 33-44.
21. Rai B., et al. “Dyke-Davidoff-Masson Syndrome: A rare cause of childhood hemiplegia”. Journal of Nepal Paediatric Society (JNPS)1 (2014): 80-82.
22. Behera MR., et al. “Dyke-Davidoff-Masson syndrome”. Journal of Neurosciences in Rural Practice 3 (2012): 411-413.

Citation

Citation: Bakare Aminat K., et al. “Dyke-Davidoff-Masson Syndrome Presenting with Recurrent Seizures and Hemifacial Asymmetry: A Case Report from Abeokuta, Nigeria".Acta Scientific Neurology 8.11 (2025): 03-08.

Copyright

Copyright: © 2025 Bakare Aminat K., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.