Masato Hidaka¹, Shinji Yamashita¹*, Tsuyoshi Fukushima², Natsuki Ogasawara¹, Mitsuru Tamura¹, Tomoki Kawano¹, Fumitaka Matsumoto¹, Hironobu Okuyama¹, Nei Fukasawa³, Junko Hirato⁴, Yuichiro Sato² and Yoshiko Okita¹

¹Department of Neurosurgery, Faculty of Medicine, University of Miyazaki, Kihara, Kiyotake, Miyazaki, Japan
²Section of Oncopathology and Morphological Pathology, Department of Pathology, Faculty of Medicine, University of Miyazaki, Kihara, Kiyotake, Miyazaki, Japan
³Department of Pathology, The Jikei University School of Medicine, Nishi-Shimbashi, Minato-ku, Tokyo, Japan
⁴Department of Pathology, Public Tomioka General Hospital, Tomioka, Gunma, Japan

*Corresponding Author: Shinji Yamashita, Department of Neurosurgery, Faculty of Medicine, University of Miyazaki, Kihara, Kiyotake, Miyazaki, Japan.

Received: April 14, 2025; Published: April 28, 2025

Abstract

Dysembryoplastic neuroepithelial tumors (DNTs) are low-grade mixed glioneuronal tumors. They are rare tumors mostly located in the cerebral cortex, particularly in the temporal lobe, and are associated with intractable complex partial seizures in young patients. Here, we present the case of an 8-year-old child with upper left and external strabismus with a challenging pathological diagnosis. Magnetic resonance imaging (MRI) revealed a tumor expanding into the midbrain, right thalamus, and right medial temporal lobe. The tumor was predominantly located in the white matter and infiltrated the cortex of the right medial temporal lobe. Based on the patient's profile, neurological symptoms, and neuroradiological findings, the tumor was interpreted as a possible diffuse midline glioma. Surgery was performed, and the right temporal lobe, mainly the white matter containing the medial cortex, was resected. Morphological features of DNT, such as floating neurons, were present only in the cortex at the edge of the resected tumor and were difficult to distinguish. In this case, DNT presented with atypical radiological and symptomatic findings, making the pathological diagnosis of a lesion with infiltration of the cortex uncertain. This study advocates a multidisciplinary diagnostic procedure for atypical radiological and symptomatic DNT findings.

 Keywords: DNA Methylation Profiling; Dysembryoplastic Neuroepithelial Tumor; White Matter Tumor

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Citation

Citation: Shinji Yamashita., et al. “Dysembryoplastic Neuroepithelial Tumor in an Atypical Location without Epilepsy: A Case Report. Acta Scientific Neurology 8.4 (2025): 89-94.

Copyright

Copyright: © 2025 Shinji Yamashita., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.