Takashi Kon¹, Yosuke Sato^1,2*, Yusuke Kobayashi¹, Kosuke Tanaka², Junichiro Takahashi² and Yoichi Morofuji¹

¹Department of Neurosurgery, Showa Medical University, Tokyo, Japan
²Brain Function Analysis and Digital Medicine Research Institute, Showa Medical University, Tokyo, Japan

*Corresponding Author: Yosuke Sato, Director, Brain Function Analysis and Digital Medicine Research Institute, Showa Medical University, Tokyo, Japan.

Received: April 24, 2025; Published: April 30, 2025

Abstract

Objective: 5-aminolevulinic acid (5-ALA) is used for intraoperative tumor visualization in neurosurgery. We hypothesized that 5-ALA fluorescence intensity may vary according to glioma pathology.

Methods: We investigated 28 patients with glioma who underwent surgery between 2019 and 2023. 5-ALA was administered before surgery, and the intensity of 5-ALA fluorescence was quantified intraoperatively. The pathological diagnosis was based on the 2016 World Health Organization classification.

Results: Seventeen patients with glioblastoma (GBM), four with anaplastic astrocytoma (AA), three with oligodendroglioma (OL), and four with low-grade glioma (LGG) were examined. The mean (SD) intensity of the 5-ALA fluorescence was 155.9 (56.0) in GBM, 180.5 (64.7) in AA, and 66.3 (18.8) in OL. The intensity in OL was significantly lower than that in GBM and AA (Scheffé’s test, P < .05). All LGGs were negative.

Conclusions: The intensity of 5-ALA fluorescence varies by pathology, which may contribute to intraoperative diagnostic support.

 Keywords: 5-Aminolevulinic Acid (5-ALA); Anaplastic Astrocytoma (AA); Magnetic Resonance Imaging (MRI)

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Citation

Citation: Yosuke Sato., et al. “Quantitative Analysis of 5-aminolevulinic Acid Fluorescence Intensity in Glioma Surgery: A Retrospective Study”. Acta Scientific Neurology 8.5 (2025): 64-67.

Copyright

Copyright: © 2025 Yosuke Sato., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.