Ayşe Buse Melik¹, Lara Bilici¹, Gazanfer Ekinci², Fahrettin Keleştimur³, Uğur Türe⁴ and Aydın Sa ⁵*

¹Yeditepe University, School of Medicine, Turkey
²Department of Radiology, Yeditepe University, Koşuyolu Hospital, Turkey
³Department of Endocrinology, Yeditepe University, Koşuyolu Hospital, Turkey
⁴Department of Neurosurgery, Yeditepe University, Koşuyolu Hospital, Turkey
⁵Department of Pathology, Yeditepe University, Koşuyolu Hospital, Turkey

*Corresponding Author: Aydın Sav, Department of Pathology, Yeditepe University, Koşuyolu Hospital, Turkey.

Received: December 02, 2024; Published: December 31, 2024

Abstract

Two patients admitted to the hospital were to have sellar masses with similar locations and neuroradiological features but dispatched dissimilar morphologic and immunohistochemical features. Presumptive diagnoses were meningioma of the first case, and pituitary adenoma for the latter. Pathologic examination of these cases revealed a common TTF-1 positivity but divergent morphology, and immunohistochemistry other than TTF-1 reactivity. Although they are known as TTF-1 positive tumors of the posterior pituitary due to their morphological and immunohistochemical differences, pituicytoma and spindle cell oncocytoma are not similar. The fact that it was shown in this study that pituicytoma is especially rich in reticulum is a histopathological finding that should be kept in mind. TTF-1 positive tumors, thought to originate from posterior pituitary pituicytes, do not resemble each other due to their morphological and immunohistochemical properties. In the differential diagnosis of sellar and parasellar masses, posterior pituitary tumors other than pituitary adenoma, chordoma, and meningioma are among the differential diagnoses.

 Keywords: Granular Cell Tumor; Pituicytoma; Posterior Pituitary; TTF-1 Positive Tumors

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Citation

Citation: Aydın Sav., et al. “Rare TTF-1 Posterior Pituitary Tumors with Distinctive Morphologic and Immunohistochemical Features: Mini-Series - Two Cases”. Acta Scientific Neurology 8.1 (2025): 21-27.

Copyright

Copyright: © 2025 Aydın Sav., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.