Abderrazzak AJERTIL*, Najat KABBAJ and Abdeljalil EL QUESSAR

Department of Radiology, Cheikh Zayd International University Hospital, UIASS, Rabat, Morocco

*Corresponding Author: Abderrazzak AJERTIL, Department of Radiology, Cheikh Zayd International University Hospital, UIASS, Rabat, Morocco.

Received: October 31, 2024; Published: December 19, 2024

Abstract

Cerebral vasculitis, though rare, represents a serious complication of systemic lupus erythematosus (SLE) and poses numerous challenges in terms of management due to its potential for severe neurological consequences and often poor prognosis. We report the case of a 32-year-old man with SLE who presented with three seizure episodes and cognitive deterioration. Neurological examinations, laboratory analyses, and imaging findings led to a diagnosis of cerebral vasculitis secondary to SLE. Despite intensive immunosuppressive treatment, the patient’s neurological condition deteriorated, resulting in multiorgan failure. Ultimately, the patient died due to multiorgan failure linked to severe central nervous system vasculitis and associated complications. This case highlights the importance of early detection and aggressive treatment of cerebral vasculitis in the context of SLE.

 Keywords: Systemic Lupus Erythematosus (SLE); Cerebral Vasculitis; Neurological Complications; Multiorgan Failure; Immunological Dysfunction

References

1. Bertsias GK., et al. “EULAR recommendations for the management of systemic lupus erythematosus with neuropsychiatric manifestations: report of a task force of the EULAR standing committee for clinical affairs”. Annals of the Rheumatic Diseases 12 (2010): 2074-2082.
2. Hanly JG., et al. “Neuropsychiatric events at the time of diagnosis of systemic lupus erythematosus: an international inception cohort study”. Arthritis and Rheumatology 1 (2007): 265-273.
3. Zhang X., et al. “Central nervous system involvement in systemic lupus erythematosus”. Zhonghua Nei Ke Za Zhi10 (1999): 681-684.
4. Govoni M., et al. “The diagnosis and clinical management of the neuropsychiatric manifestations of lupus”. Journal of Autoimmunity 74 (2016): 41-72.
5. Thirunavukkarasu B., et al. “Neuropathological spectrum in systemic lupus erythematosus: A single institute autopsy experience”. Journal of Neuroimmunology 353 (2021): 577518.
6. Emerson JS., et al. “The conundrum of neuropsychiatric systemic lupus erythematosus: Current and novel approaches to diagnosis”. Frontiers in Neurology 14 (2023): 1111769.
7. Jennette JC., et al. “2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides”. Arthritis and Rheumatology 1 (2013): 1-11.
8. Bertsias GK., et al. “Joint European League Against Rheumatism and European Renal Association-European Dialysis and Transplant Association (EULAR/ERA-EDTA) recommendations for the management of adult and paediatric lupus nephritis”. Annals of the Rheumatic Diseases 11 (2012): 1771-1782.
9. Fanouriakis A., et al. “2019 update of the EULAR recommendations for the management of systemic lupus erythematosus”. Annals of the Rheumatic Diseases 6 (2019): 736-745.
10. Lassere MN., et al. “Definitions and validation criteria for biomarkers and surrogate endpoints: development and testing of a quantitative hierarchical levels of evidence schema”. The Journal of Rheumatology 3 (2007): 607-615.

Citation

Citation: Abderrazzak AJERTIL., et al. “Cerebral Vasculitis in Systemic Lupus Erythematosus (SLE) : Case Report and Literature Review”. Acta Scientific Neurology 8.1 (2025): 10-13.

Copyright

Copyright: © 2025 Abderrazzak AJERTIL. , et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.