The Role of Bedside Optic Nerve Sheath Diameter in Prognosticating Mortality in Head Injury Patients: A Prospective Study
Busaraben Gandhi1, Stuti Juneja2, Manoj Soman3,4* and Unnikrishnan Nair3,4
1Medical Retina Research Fellow, London Northwest University Hospital and Research Institute, London, United Kingdom
2Associate Professor and In-Charge, Head of the Department of Ophthalmology, Medical College Vadodara, Vadodara, Gujarat, India
3Vitreoretinal Services, Chaithanya Eye Hospital and Research Institute, Trivandrum, Kerala, India
4Chaithanya Innovation in Technology and Eyecare (Research), Trivandrum, Kerala, India
*Corresponding Author: Manoj Soman, Vitreoretinal Services, Chaithanya Eye Hospital and Research Institute, Trivandrum, Kerala, India.
Received:
September 26, 2024; Published: November 20, 2024
Abstract
Objective: To assess the role of optic nerve sheath diameter (ONSD) in predicting mortality, with the goal of reducing overall mortality through early recognition and appropriate interventions.
Design: Prospective study.
Methodology: A study of 180 head injury cases was conducted at a tertiary care hospital over one year to evaluate various ocular manifestations. The Glasgow Coma Scale (GCS) was used to assess head injury severity. Bed side ocular examination and ONSD measurements in primary gaze and in supine position using USG B-scan were obtained. Statistical analysis was done using the chi-square test and descriptive statistics. Ocular neurological signs, ONSD values, and GCS scores were correlated with survival outcomes.
Outcome Measures: In this study of 180 head injury patients, 91.11% had ocular involvement. Most patients were male (88.33%) and between 21-30 years old. Road traffic accidents (81.11%) were the leading cause of injury. Cranial nerve palsies, notably third nerve palsy (2.22%), and pupillary abnormalities (29.44%) were observed. Glasgow Coma Scale (GCS) scores, and optic nerve sheath diameter (ONSD) ≥5mm significantly (P < 0.0001 for each) correlated with mortality.
Conclusions: Ocular manifestations were present in 91.11% of head injury cases. An ONSD ≥5 mm was highly associated with mortality. Increased ONSD could serve as a surrogate bedside measure of prognosis and survival in patients of head injuries.
Keywords: Glasgow Coma Scale; Head Injury; Optic Nerve Sheath Diameter; Mortality Prediction
References
- Dewan MC., et al. “Estimating the Global Incidence of Traumatic Brain Injury”. Journal of Neurosurgery (2018): 1-18.
- Nehra A and S Bajpai. “Effectiveness of Cognitive Retraining after Brain Trauma-Case Studies”. Activitas Nervosa Superior 54 (2012): 139-145.
- Emer JM., et al. “Orbital Floor Fractures: Long-Term Follow up of Cases with and without Surgical Repair”. Transactions Ophthalmology Otolaryngology 75 (1971): 801-812.
- Malik A., et al. “Ocular Manifestations of Head Injury: A Clinical Study”. Sudanese Journal of Ophthalmology 8 (2016): 46-50.
- Kulkarni AR., et al. “Ocular Manifestations of Head Injury: A Clinical Study”. Eye (London) 19 (2005): 1257-1263.
- Odebode TO., et al. “Ocular and Visual Complications of Head Injury”. Eye (London) 19 (2005): 561-566.
- Selassie AW., et al. “Incidence of Long-Term Disability Following Traumatic Brain Injury Hospitalization, United States, 2003”. The Journal of Head Trauma Rehabilitation 23 (2008): 123-131.
- Myburgh JA., et al. “Epidemiology and 12-Month Outcomes from Traumatic Brain Injury in Australia and New Zealand”. Journal of Trauma 64 (2008): 854-862.
- Saini NS., et al. “Factors Predicting Outcome in Patients with Severe Head Injury: Multivariate Analysis”. Indian Journal of Neurotrauma 9 (2012): 45-47.
- Roozenbeek B., et al. “Prediction of Outcome After Moderate and Severe Traumatic Brain Injury: External Validation of the International Mission on Prognosis and Analysis of Clinical Trials (IMPACT) and Corticoid Randomisation After Significant Head Injury (CRASH) Prognostic Models”. Critical Care Medicine 40 (2012): 1609-1617.
- Vella MA., et al. “Acute Management of Traumatic Brain Injury”. Surgical Clinics of North America (2017).
- Strumwasser A., et al. “Raised Intracranial Pressure in Those Presenting with Headache”. BMJ (2018).
- Unknown Authors. “Sonographic Optic Nerve Sheath Diameter as an Estimate of Intracranial Pressure in Adult Trauma”. Journal of Surgical Research (2011).
- Hansen HC and K Helmke. “The Subarachnoid Space Surrounding the Optic Nerves: An Ultrasound Study of the Optic Nerve Sheath”. Surgical and Radiologic Anatomy4 (1996): 323-328.
- Sahasrabudhe V and A Sonkamble. “Ocular Manifestations in Head Injury: A Clinical Study”. International Journal of Medical Research Professionals4 (2017): 79-83.
- Kumari R., et al. “Ocular Manifestations in Head Injury Patients: A Prospective Study”. International Journal of Contemporary Medical Research 8 (2017): 1648-1651.
- Frumin E., et al. “Prospective Analysis of Single Operator Sonographic Optic Nerve Sheath Diameter Measurement for Diagnosis of Elevated Intracranial Pressure”. The Western Journal of Emergency Medicine 15 (2014): 217‐220.
- Lee LA., et al. “Perioperative Head Injury Management in the Multiply Injured Trauma Patient”. International Anesthesiology Clinics 40 (2002): 31‐52.
- Bajoghli M., et al. “Children, CT Scan and Radiation”. International Journal of Preventive Medicine 1 (2010): 220‐222.
- Sarkisian AE., et al. “Sonographic Screening of Mass Casualties for Abdominal and Renal Injuries Following the 1988 Armenian Earthquake”. Journal of Trauma 31 (1991): 247‐250.
- Karakitsos D., et al. “Transorbital Sonographic Monitoring of Optic Nerve Diameter in Patients with Severe Brain Injury”. Transplantation Proceedings 38 (2006): 3700‐3706.
- Girisgin AS., et al. “The Role of Optic Nerve Ultrasonography in the Diagnosis of Elevated Intracranial Pressure”. Emergency Medicine Journal 24 (2007): 251‐254.
- Goel RS., et al. “Utility of Optic Nerve Ultrasonography in Head Injury”. Injury 39 (2008): 519‐524.
- Soldatos T., et al. “Optic Nerve Sonography: A New Window for the Non-Invasive Evaluation of Intracranial Pressure in Brain Injury”. Emergency Medicine Journal 26 (2009): 630.
- Dubourg J., et al. “Ultrasonography of Optic Nerve Sheath Diameter for Detection of Raised Intracranial Pressure: A Systematic Review and Meta-Analysis”. Intensive Care Medicine 37 (2011): 1059‐1068.
- Messerer M., et al. “Interest of Optic Nerve Sheath Diameter Ultrasonography in Detecting Non-Invasively Raised Intracranial Pressure”. Neurochirurgie 59 (2013): 55‐59.
- Guthoff R and JM Thijssen. “Ultrasound in Ophthalmologic Diagnosis: A Practical Guide”. Georg Thieme Verlag (1991).
- Ossoinig KC. “Standardized Echography of the Optic Nerve”. In Ophthalmic Echography, 13th, Springer (1993): 3‐99.
- Blaivas M., et al. “Elevated Intracranial Pressure Detected by Bedside Emergency Ultrasonography”. Case Reports in Emergency Medicine (2015).
- Kimberly HH., et al. “Correlation of Optic Nerve Sheath Diameter with Direct Measurement of Intracranial Pressure”. Academic Emergency Medicine 15 (2008): 201‐204.
- Amini A., et al. “Use of the Sonographic Diameter of Optic Nerve Sheath to Estimate Intracranial Pressure”. The American Journal of Emergency Medicine 31 (2013): 236‐239.
- Kaur Amandeep., et al. “Bedside Ultrasonographic Assessment of Optic Nerve Sheath Diameter as a Means of Detecting Raised Intracranial Pressure in Neuro-Trauma Patients: A Cross-Sectional Study”. Annals of Indian Academy of Neurology 1 (2021): 63-68.
Citation
Copyright