Merina Antony¹*, Namitha MV¹, Gaurav² and Karthik A²

¹House Surgeon, Coorg Institute of Dental Sciences, Virajpet, Karnataka
²Associate Professor, Department of Oral Medicine and Radiology, Coorg Institute of Dental Sciences, Viraj pet, Karnataka, India

*Corresponding Author: Merina Antony, House Surgeon, Coorg Institute of Dental Sciences, Virajpet, Karnataka.

Received: June 24, 2024; Published: July 11, 2024

Abstract

Background: Neuritin, also known as CPG-15 is a protein that plays a crucial role in neural development and synaptic plasticity. Apart from this neurological function, Neuritin has been recognised for its potential role in various immunological functions. Recent researches have proven that regulatory T cells, (a subset of T lymphocytes) involved in immune regulation, are associated with Neuritin production and could potentially modulate numerous immune responses. Based on few clinical studies, the production of Neuritin in the body with the help of foxP3 signaling pathway could act as a potential weapon against anaphylactic (IgG) and atopy (IgE) related Hypersensitivity reactions.

Aim: To determine the significance of targeting Neuritin protein in order to treat conditions like Allergy and Autoimmunity.

Research question: Will targeting Neuritin protein bring a new wave in combating Hypersensitivity reactions?

Materials and Methodology: With the Medline, Cochrane and Medknow database taken as reference, 16 articles that have undergone Randomized Control Trial was selected for the study after having met the criterion for Systematic Review.

Results: Statistical analysis confirms significance, supporting the null hypothesis that targeting Neuritin protein effectively treats Hypersensitivity and Autoimmune diseases.

 Keywords: Neuritin; Hypersensitivity; Autoimmunity; Targeted Therapy; Follicular B Cell; Treg Cells; Teff Cells; IgE Mediated Allergies

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Citation

Citation: Merina Antony., et al. ““NEURITIN”: An Inbuilt Weapon Against Hypersensitivity Reactions-A Systematic Review”. Acta Scientific Neurology 7.8 (2024): 19-22.

Copyright

Copyright: © 2024 Merina Antony., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.