Frans J Cronje¹, Ronald Swatzyna², Igor Elman³, Panayotis K Thanos⁴, Kai-Uwe Lewandowski^5-7, Alireza Sharafshah⁸, Rajendra D. Badgaiyan⁹, Aryeh R Pollack¹⁰, Vaisakh S Syamala¹¹, Vivek Mathew¹² and Kenneth Blum^6,10,13*

¹Department of Internal Medicine, American Mission Hospital, Manama, Kingdom of Bahrain
²Neurophysiology Research at Houston Neuroscience Brain Center, Houston, TX., USA
³Department of Psychiatry, Harvard University School of Medicine, Cambridge, MA., USA
⁴Department of Pharmacology and Toxicology, University of Buffalo, Jacob School of Medicine, Buffalo, NY., USA
⁵Department of Orthopaedics, Fundación Universitaria Sanitas Bogotá D.C. Colombia
⁶Center for Advanced Spine Care of Southern Arizona, Tucson, AZ, USA
⁷Department of Orthopaedics, Universidade Federal do Estado do Rio de Janeiro, Brazil
⁸Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
⁹Department of Psychiatry, Mt. Sinai School of Medicine, New York, NY, USA
¹⁰The Blum Institute of Neurogenetics and Behavior, Austin, TX., USA
¹¹Department of Neurology, American Mission Hospital, Manama, Kingdom of Bahrain
¹²Department of Psychiatry, American Mission Hospital, Manama, Kingdom of Bahrain
¹³Center for Sports, Exercise, Mental Health, Western University Health Sciences, Pomona., CA., USA

*Corresponding Author: Frans J Cronje, Department of Internal Medicine, American Mission Hospital, Manama, Kingdom of Bahrain.

Received: May 13, 2024; Published: June 25, 2024

Abstract

Background: Quantitative electroencephalography (qEEG) has proven invaluable in assessing the neuropsychological impact of various substances, providing insight into their effects on brain activity and cognitive functions. KB220, a nutraceutical neuroadaptogen, has shown promise in modifying the dopaminergic system to enhance cognitive and neurological functions without dependency risks.

Case Presentation: A 26-year-old male with a history of multiple neuropsychiatric diagnoses, including ADHD, PTSD, and sensory integration disorder, underwent qEEG analysis to explore the effects of KB220 on brain function. The patient's EEG was recorded before and 60 minutes after oral administration of KB220, observing changes in various frequency bands indicative of cognitive and alertness states.

Methods: Baseline and post-administration EEG recordings were analyzed to assess changes in Delta, Theta, Alpha, and Beta wave activities, which correlate with alertness, memory processing, and cognitive engagement. The study utilized a 19-channel EEG with a consistent setup to ensure accurate comparative results.

Results: Significant alterations were observed in the patient's EEG post-KB220 administration. There was a notable reduction in Delta activity, suggesting increased alertness. Theta and Alpha activities increased, indicating enhanced working memory and neuronal synchrony. Beta activity changes suggested improved focus and cognitive processing. These shifts point towards restoring dopamine homeostasis, potentially enhancing brain activity and cognitive functions.

Conclusion: The case highlights the potential of KB220 to significantly impact brain function and cognitive performance through modulation of the dopaminergic system. These findings support further research into KB220 as a beneficial treatment for cognitive delays and neuropsychiatric conditions beyond traditional applications in addiction and reward deficiency syndrome. The data suggest a broader utility for KB220 in improving cognitive outcomes in patients with complex neuropsychiatric profiles.

 Keywords: Hypothesizing; Brain; Dopamine; KB220; Cognitive

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Citation

Citation: Frans J Cronje., et al. “Hypothesizing Enhanced Brain Activity as A Function of Dopamine Homeostasis as Observed with KB220 in A Male with Delayed Cognitive Performance”. Acta Scientific Neurology 7.7 (2024): 49-56.

Copyright

Copyright: © 2024 Frans J Cronje., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.