Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Review Article Volume 7 Issue 6

Neurophysiology Of Obstructive Sleep Apnea

Kalpana AP1*, Kannabiran B2, Nagarani R2 and Sivakumar S3

1Ph.D. Scholar, RVS College of Physiotherapy /Professor, KMCH College of Physiotherapy, Coimbatore Affiliated to the Tamil Nadu Dr. MGR Medical University, Chennai, India
2Professor/Ph.D. Guide, RVS College of Physiotherapy, Coimbatore Affiliated to the Tamil Nadu Dr. MGR Medical University, Chennai, India
3Professor KMCH College of Physiotherapy, Coimbatore, The Tamil Nadu Dr. M. G. R. Medical University, Chennai, India

*Corresponding Author: Kalpana AP, Ph.D. Scholar, RVS College of Physiotherapy /Professor, KMCH College of Physiotherapy, Coimbatore Affiliated to the Tamil Nadu Dr. MGR Medical University, Chennai, India.

Received: March 15, 2024; Published: May 20, 2024

Abstract

Obstructive sleep apnea is often an undiagnosed condition worldwide. Untreated sleep apnea may lead to many adverse consequences such as cardiovascular events, road traffic accidents, and fatigue. Hence there is a need to address the neurophysiological changes associated with obstructive sleep apnea. This review of evidence on the neurophysiology of OSA showed the changes in neuronal activity during the sleep-wake cycle. Snoring, a common symptom of OSA induces vibratory trauma to the upper airway muscles. Various imaging techniques showed the significance of genioglossus muscle in maintaining airway stability during sleep and reduced muscle activation increases the pharyngeal resistance and predisposes to collapse. Ultrasound measurement of the diaphragm of OSA patients noticed the increased thickness of the diaphragm compared with the age-matched subjects. Increased sympathetic activity was observed in OSA patients. A high level of evidence is needed in the area of neuro-physiological changes in obstructive sleep apnea patients.

Keywords: Neurophysiology; Obstructive Sleep; Apnea

References

  1. Abhishek Goyal., et al. “Prevalence of OSA in Indian population and diagnostic accuracy of different tools for OSA”. ERJ Open Research11 (2023): 58.
  2. Pinto AM., et al. “Obstructive Sleep Apnea in a rural population in South India: Feasibility of health care workers to administer level III sleep study”. Lung India4 (2018): 301-306.
  3. Harding SM. “Complications and consequences of obstructive sleep apnea”. Current Opinion in Pulmonary Medicine6 (2000): 485-489.
  4. Waters Tina and Reena Mehra. “Clinical neurophysiology of apnea.” Handbook of Clinical Neurology 161 (2019): 345-352.
  5. White David P. “Pathogenesis of obstructive and central sleep apnea”. American Journal of Respiratory and Critical Care Medicine11 (2005): 1363-1370.
  6. Hussain Iqram., et al. “Quantitative Evaluation of EEG-Biomarkers for Prediction of Sleep Stages”. Sensors (Basel, Switzerland)8 (2022): 3079.
  7. Sulaman Bibi A., et al. “Neuro-orchestration of sleep and wakefulness”. Nature Neuroscience2 (2023): 196-212.
  8. Fuller Patrick M., et al. “Neurobiology of the sleep-wake cycle: sleep architecture, circadian regulation, and regulatory feedback”. Journal of Biological Rhythms6 (2006): 482-493.
  9. Peever John and Patrick M Fuller. “The Biology of REM Sleep”. Current Biology: CB22 (2017): R1237-R1248.
  10. Shiromani Priyattam J and John H Peever. “New Neuroscience Tools That Are Identifying the Sleep-Wake Circuit”. Sleep4 (2017): zsx032.
  11. Chokroverty S. “Overview of sleep and sleep disorders”. The Indian Journal of Medical Research 131 (2010): 126-140.
  12. Sembuling K and Sembuling P. “Essential of Medical Physiology. 6th Edition”. New Jaypee Brothers Medical Publishers, Delhi, India (2012).
  13. Holfinger S., et al. “Neurobiology of Obstructive Sleep Apnea”. Oxford Research Encyclopedia of Neuroscience (2021).
  14. Andrisani G and Andrisani G. “Sleep apnea pathophysiology”. Sleep Breath 27 (2023): 2111-2122 (2023).
  15. Liu P., et al. “Clinical Predictors of Mixed Apneas in Patients with Obstructive Sleep Apnea (OSA)”. Nature and Science of Sleep 14 (2022): 373-380.
  16. Yamauchi M., et al. “Differences in breathing patterning during wakefulness in patients with mixed apnea-dominant vs obstructive-dominant sleep apnea”. Chest 140.1 (2011): 54-61.
  17. Zimmerman Molly E and Mark S Aloia. “A review of neuroimaging in obstructive sleep apnea”. Journal of Clinical Sleep Medicine: JCSM: Official publication of the American Academy of Sleep Medicine4 (2006): 461-471.
  18. Rogić Vidaković Maja., et al. “Obstructive Sleep Apnea Syndrome: A Preliminary Navigated Transcranial Magnetic Stimulation Study”. Nature and Science of Sleep12 (2020): 563-574.
  19. Philip-Joet F., et al. “Effects of genioglossal response to negative airway pressure on upper airway collapsibility during sleep”. Journal of Applied Physiology 80 (1996): 1466-1474. 
  20. Pierce R., et al. “Upper airway collapsibility, dilator muscle activation and resistance in sleep apnoea”. The European Respiratory Journal2 (2007): 345-353.
  21. Nguyen AT., et al. “Laryngeal and velopharyngeal sensory impairment in obstructive sleep apnea”. Sleep 28 (2005): 585-593.
  22. Bradley TD., et al. “Pharyngeal size in snorers, non-snorers, and patients with obstructive sleep apnea”. The New England Journal of Medicine 315 (1986): 1327-1331.
  23. Fogel RB., et al. “ 2: pathophysiology of obstructive sleep apnoea/hypopnoea syndrome.” Thorax59.2 (2004): 159-163.
  24. Malhotra A., et al. “Aging influences on pharyngeal anatomy and physiology: the predisposition to pharyngeal collapse”. The American Journal of Medicine 1 (2006): 72.e9-14.
  25. Almendros I., et al. “Metabolic dysfunction in OSA: is there something new under the sun?” Journal of Sleep Research 31 (2022): e13418.
  26. Pal A., et al. “Insular functional organization during handgrip in females and males with obstructive sleep apnea”. PLoS One 16 (2021): e0246368.
  27. Li H., et al. “Abnormal intrinsic functional hubs and connectivity in stable patients with COPD: a resting-state MRI study”. Brain Imaging and Behavior 14 (2020): 573-585.
  28. Molnár V., et al. “Examination of the diaphragm in obstructive sleep apnea using ultrasound imaging”. Sleep Breath 26 (2022): 1333-1339.
  29. Marra L., et al. “The association between dysphagia and OSA”. ACTA Otorhinolaryngologica Italica 42 (2002): 82-88.

Citation

Citation: Kalpana AP., et al. “Neurophysiology Of Obstructive Sleep Apnea”. Acta Scientific Neurology 7.6 (2024): 11-14.

Copyright

Copyright: © 2024 Kalpana AP., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate32%
Acceptance to publication20-30 days

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is July 10, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US