Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Case Report Volume 7 Issue 5

Hemiplegic Migraines Exacerbated using an Injectable GLP-1 Agonist for Weight Loss

Edward J Modestino1*, Abdalla Bowirrat2, Kai-Uwe Lewandrowski3,4, Alireza Sharafshah5, Rajendra D Badgaiyan6, Panayotis K Thanos7, David Baron8, Catherine A Dennen9, Igor Elman10, Keerthy Sunder11, Kevin T Murphy12 and Kenneth Blum2,4,8,12,13

1Department of Psychology, Curry College, Milton, MA, USA
2Department of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel, Israel
3Department of Orthopaedics, Fundación Universitaria Sanitas, Bogotá, DC, Colombia
4Division of Personalized Pain Therapy and Education, Center for Advanced Spine Care of Southern Arizona, Tucson, AZ, USA
5Cellular and Molecular Research Center, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
6Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA
7Behavioral Neuropharmacology and Neuroimaging Laboratory, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, Clinical Research Institute on Addictions, University at Buffalo, Buffalo, NY, USA
8Center for Sports, Exercise, Global Mental Health, Western University Health Sciences, Pomona, CA, USA
9Department of Family Medicine, Jefferson Health Northeast, Philadelphia, PA, USA
10Department of Psychiatry, Harvard University School of Medicine, Cambridge, MA., USA
11Department of Medicine, University of California, Riverside School of Medicine, Riverside, CA, USA
12Karma Doctors & Karma TMS, and Suder Foundation, Palm Springs, CA, USA
13Division of Personalized Neuromodulation, PeakLogic, LLC., Del MAR, CA., USA

*Corresponding Author: Edward J Modestino, Department of Psychology, Curry College, Milton, MA, USA.

Received: February 22, 2024; Published: April 19, 2024

Abstract

The widespread adoption of Glucagon-like peptide-1 (GLP-1) receptor agonists for the treatment of obesity and diabetes has raised concerns about their potential adverse effects, including the induction of depression and suicide ideation. We report on a male patient in his early 50s with a complex medical history, including adult Attention-Deficit/Hyperactive Disorder, narcolepsy with cataplexy, and major depressive disorder in remission, who experienced exacerbated hemiplegic migraines after initiating treatment with an injectable GLP-1 agonist (Saxenda) for weight loss. Despite a previous history of experiencing hemiplegic migraines once or twice a year, the patient reported daily occurrences of migraines, many of which were hemiplegic, during the 60 days of GLP-1 agonist treatment. The migraines abated only upon discontinuation of the medication. This case underscores the need to carefully consider patient history and potential genetic predispositions when prescribing GLP-1 agonists, highlighting the complex interactions between these medications, existing comorbidities, and the dopaminergic and calcitonin gene-related peptide pathways. Our findings suggest that GLP-1 agonists, while beneficial for some, may pose significant risks for patients with specific genetic backgrounds or neurological conditions, calling for personalized approaches to treatment and increased awareness of potential adverse effects.

 Keywords: Hemiplegic Migraines; Injectable Glp1; Weight Loss; Adverse Effects

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Citation

Citation: Edward J Modestino., et al. “Hemiplegic Migraines Exacerbated using an Injectable GLP-1 Agonist for Weight Loss”. Acta Scientific Neurology 7.5 (2024): 12-18.

Copyright

Copyright: © 2024 Edward J Modestino., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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