Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Review Article Volume 6 Issue 7

Threat of COVID-19 Infection Over the Human Brain: A Neurological Perspective

Krishan Gopal Pathak1, Kajol1, Anil Sisodia2 and Arun Pratap Sikarwar1

1Department of Zoology, Faculty of Science, Dayalbagh Educational Institute (Deemed University), Agra, Uttar Pradesh, India
2Professor, Institute of Mental Health and Hospital, Agra, Uttar Pradesh, India

*Corresponding Author: Arun Pratap Sikarwar, Department of Zoology, Faculty of Science, Dayalbagh Educational Institute (Deemed to be University), Agra, India.

Received: April 10, 2023; Published: June 05, 2023


At present time the eruption of novel coronavirus allied COVID-19 disease has potentially spread and engrossed almost whole world. The world is reeling under the disaster caused by corona virus disease (SARS-CoV-2). In this review article we discuss and relate the some neurological disorder, fear and anxiety due to corona virus (SARS-CoV-2). The SARS-CoV-2 is the seventh virus of corona virus family known to infect human beings. Although the diseases have different clinical presentations, the infectious cause, epidemiological features, fast spread pattern, and deficient preparedness of health authorities to address the outbreaks are similar. So far, mental health care for the patients and health professionals directly affected. Several viral infections can cause severe harm to the structure and function of the nervous system, severe encephalitis due to viral infections in the CNS, toxic encephalopathy, and severe acute demyelinating injuries progressing after viral infections. COVID-19 virus exploits the angiotensin converting enzyme-2 (ACE2) receptor to gain entrance inside the human cells. This finding raises the curiosity of investigating the expression of ACE2 in neurological tissue and determining the possible contribution of neurological tissue damage to the morbidity and mortality caused by COVID-19. The SARS-CoV-2, like other coronaviruses such as SARS-CoV and MERS-CoV, could target the central nervous system, possibly infecting neurons in the nasal passage and disrupting the senses of smell and taste. The SARS-CoV-2 infects nerve cells, particularly neurons in the medulla oblongata, which is part of the brain stem that serves as the control centre for the heart and the lungs. Researcher have found the virus in the brain and cerebrospinal fluid (CSF), which probably causes different brain diseases such as cerebral haemorrhage, encephalitis, and nerve demyelination. The most prominent way to enter corona virus in the human body is the nasal pathway, which makes a channel to brain through olfactory tract. Hence, the COVID-19 may disrupt sense of smell (hyposmia) and becomes early symptoms of disease that also effects on the taste (dysgeusia). Pandemics can lead to heightened levels of stress; Anxiety is a common reaction to any tense situation.

Keywords: COVID-19; Dysosmia; Dysgeusia; Neurological Disease; Anxiety


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Citation: Krishan Gopal Pathak., et al. “Threat of COVID-19 Infection Over the Human Brain: A Neurological Perspective". Acta Scientific Neurology 6.7 (2023): 10-15.


Copyright: © 2023 Arun Pratap Sikarwar., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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