Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Research Article Volume 6 Issue 6

Impaired Psychomotor Speed Functions in Patients Who Recovered from Acute Lassa Fever Infection: A 30-Days Follow-Up Study

Sunmonu TA1*, Owhin SO2, Abejegah C3, Kareem AO3, Etafo I3 and Ayodeji OO3

1Neurology Unit, Department of Medicine, Federal Medical Centre, Owo, Nigeria
2Clinical Haematology/Infectious Diseases Unit, Department of Medicine, Federal Medical Centre, Owo, Nigeria
3Department of R Community Health, Federal Medical Centre, Owo, Nigeria

*Corresponding Author: Sunmonu TA, Neurology Unit, Department of Medicine, Federal Medical Centre, Owo, Nigeria.

Received: May 09, 2023; Published: May 14, 2023


Background: Some Patients with lassa fever patients do present with delirium and encephalitis symptoms during the vital period that there is paucity of information on the cognitive and mental status of patients who have recovered from acute lassa fever infection.

Aim and Objectives: To determine the cognitive functions of patients who recovered from Lassa fever during a 30-day follow up study.

Methods: Fifty patients with Acute Lassa fever infection were studied along with fifty healthy normal controls who are seronegative to Lassa antibody test. Sociodemographic profile and clinical of the patients were collected along that of the normal, sex and educationally matched controls. Some Blood Investigation were collected from the patients for haematological test, renal and liver functions tests. Patients and Normal controls had neuropsychological test battery and the result were documented. The statistical data were analyzed by SPSS version 22.

Result: The mean age of Lassa fever patients was 41.94 ± 14.54 years while that of the controls was 37.34 ± 12.89. There was no significant difference in the sociodemographic profiles of the Lassa fever patients and the controls subject (p > 0.05). The Lassa patient has significantly prolonged auditory and binary choice reaction times when compared with normal controls (p < 0.05). while there was no difference in the visual reaction times between the Lassa fever patients and controls (p < 0.05). There was severe impairment in auditory reaction times in 14% of Lassa fever patients in the Auditory reaction times subtest.

Conclusion: Patients who recovered from Lassa fever presented with features of psychomotor speed impairment during a 30-day follow up period and this was severe in auditory support is advocated for these patients to improve their cognitive and self-management practices.

Keywords: Lassa Fever; Viral Haemorrhagic Fever; Cognitive Functions; Nigeria


  1. CDC Lassa fever 20.
  2. Domnguez de vulota F., et al. “Association of serum albumin with infection and increased mortality in clinically ill patients”. Intensive Care Medicine 7 (1980): 19-22.
  3. Okokhere F., et al. “Clinical and Laboratory Predictors of Lassa Fever outcome in a dedicated facility in Nigeria; an observational cohort study”. Lancet Infectious Disease 18 (2018): 687-695.
  4. Africa CDC Africa CDC information on lassa fever (2022).
  5. , et al. “The effect of Malaria on the Outcome of lassa fever”. The International Journal of Infectious Diseases 14.5 (2010): 172003:e333.
  6. Okokhere PO., et al. “Centre nervous system manifestation of lassa fever in Nigeria and the effect on Mortality”. Journal of the Neurological Sciences 333 (2013): e604.
  7. Duvignaud A., et al. “Lassa Fever outcomes and prognostic factor in Nigeria (LASCOPE); a prospective cohort study”. Lancet Global Health4 (2021): e469-478.
  8. Ogunrin O., et al. “Cognitive function in Nigerians with newly diagnosed epilepsy”. Canadian Journal of Neurological Sciences 2 (2000): 148-151.
  9. Arinzechi EO., et al. “A community based care- control study of prevalence and pattern of cognitive impairments in patients with epilepsy residing in South-eastern Nigeria”. Journal of Neurosciences in Rural Practice3 (2016): 405-411.
  10. Ulasi I. “Gender bias in access to health care in Nigeria; a study of end-stage renal disease”. Tropical Doctor1 (2008): e06160.
  11. Odetola TD. “Health care utilization among rural women of child beering age: a Nigerian experience”. Pan African Medical Journal 20 (2015): 151-158.
  12. Sunmonu TA., et al. “Seizure Variables and cognitive Performance in patients with epilepsy”. African Journal of Neurological Sciences2 (2008): 86-94.
  13. Hinkin CA., et al. “Medication adherence among HIV infected adults; effect of patient age, cognitive status and substance abuse”. AIDS 18 (2004): s19-s25.
  14. Hinkin CH., et al. “Medication adherence among HIV adults; effects of cognitive dysfunctions and regimen complexity”. Neurology12 (2002): 1944-1950.
  15. Ogunrin O., et al. “Cognitive function in Nigerians with newly diagnosed epilepsy”. Canadian Journal of Neurological Sciences 27 (2000): 148-151.
  16. Sunmonu TA., et al. “Cognitive functions in patients with clinically stable could to moderate) asthma in south west Nigeria, Assessment using automated neuropsychological test battery”. West African Journal of Medicine 2 (2019): 158-164.
  17. Kodl CT and seaquist ER. “Cognitive dysfunction and diabetes mellitus endocrine review”. 20.4 (2008): 494-495.
  18. Murman LD. “The Impact of age on cognition”. Seminars in Hearing3 (2015): 111-121.
  19. Centre for Disease Control Chronic disease and cognitive decline – A public health issue. Alchemers disease and healthy aging (2023).
  20. Grohn A Brave A., et al. “Imported case of Lassa fever in Sweden with encephalopathy and sensormineiral hearing deficit”. Open Forum Infections Disease4 (2016): OFW-198.
  21. Okogbenin EO., et al. “One year retrospective review of psychiatric consultations in Lassa Fever, Southern Nigeria”. Emerging Infections Diseases12 (2020): 3091-3093.


Citation: Sunmonu TA., et al. “Impaired Psychomotor Speed Functions in Patients Who Recovered from Acute Lassa Fever Infection: A 30-Days Follow-Up Study". Acta Scientific Neurology 6.6 (2023): 13-18.


Copyright: © 2023 Sunmonu TA., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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