Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Research Article Volume 6 Issue 5

Basilar Artery Thrombosis in a Young Patient with Factor V Leiden Mutation and Patent Foramen Ovale: A Case Report

Abbas Hayat Mallick1*, Ammar Ahmed2, and Vibhav Bansal3

1Medicine, Fatima Memorial Hospital College of Medicine and Dentistry, Lahore, Pakistan
2Emergency Medicine, Javon Bea Hospital, Rockford, IL, United States of America
3Neurology, Javon Bea Hospital, Rockford, IL, United States of America

*Corresponding Author: Abbas Hayat Mallick, Medicine, Fatima Memorial Hospital College of Medicine and Dentistry, Lahore, Pakistan.

Received: October 19, 2022; Published: April 16, 2023

Abstract

Introduction: Basilar artery stroke is a rare but devastating condition that requires swift diagnosis and treatment. Factor V Leiden is a hypercoagulability mutation primarily associated with venous thromboembolism, but is rarely associated with arterial atherothrombotic events such as ischemic stroke. In young patients, the presence of a PFO and prothrombotic mutation can increase the risk of cerebrovascular accidents.

Case Presentation: A 32-year-old female presented with symptoms of basilar artery thrombosis and was diagnosed through physical examination and relevant investigations. Swift initiation of IV tPA and thrombectomy procedure, as well as multidisciplinary team approach to patient care, were crucial in managing the patient's condition.

Discussion and Conclusion: The rarity of inherited thrombophilias in association with arterial thromboembolic events highlights the need for further research to better understand the etiology of such events in young patients. Considering all risk factors, including PFO and prothrombotic mutations, can help prevent cerebrovascular accidents in young patients.

Keywords: Basilar Artery Thrombosis; Deep Vein Thrombosis (DVT); Pulmonary Embolism

References

  1. Mattle HP., et al. “Basilar artery occlusion”. Lancet Neurology11 (2011): 1002-1014.
  2. Kujovich JL. “Factor V Leiden Thrombophilia”. In: Adam MP, Ardinger HH, Pagon RA, Wallace SE, Bean LJH, Gripp KW, Mirzaa GM, Amemiya A, editors. GeneReviews® [Internet]. Seattle (WA): University of Washington, Seattle; 1993– 2022 (1999).
  3. Mahmoodi BK., et al. “Association of Factor V Leiden With Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data”. Circulation6 (2020): 546-555.
  4. Schonewille WJ., et al. “Treatment and outcomes of acute basilar artery occlusion in the Basilar Artery International Cooperation Study (BASICS): a prospective registry study”. Lancet Neurology8 (2009): 724-730.
  5. Ikram A and Zafar A. “Basilar Artery Infarct”. In: StatPearls. Treasure Island (FL): StatPearls Publishing; (2022).
  6. Israeli-korn SD., et al. “Ischemic stroke due to acute basilar artery occlusion: proportion and outcomes”. Israel Medical Association Journal 11 (2010): 671-675.
  7. Alhazzani AA., et al. “Association between Factor V Gene Polymorphism and Risk of Ischemic Stroke: An Updated Meta-Analysis”. Journal of Stroke and Cerebrovascular Diseases 5 (2018): 1252-1261.
  8. Chiasakul T., et al. “Inherited Thrombophilia and the Risk of Arterial Ischemic Stroke: A Systematic Review and Meta-Analysis”. Journal of the American Heart Association 19 (2019): e012877.
  9. Saver JL., et al. “Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke”. The New England Journal of Medicine 11 (2017): 1022-1032.
  10. Mas JL., et al. “Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke”. The New England Journal of Medicine 11 (2017): 1011-1021.

Citation

Citation: Abbas Hayat Mallick., et al. “Basilar Artery Thrombosis in a Young Patient with Factor V Leiden Mutation and Patent Foramen Ovale: A Case Report". Acta Scientific Neurology 6.5 (2023): 15-18.

Copyright

Copyright: © 2023 Abbas Hayat Mallick., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate32%
Acceptance to publication20-30 days

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is June 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.

Contact US