Duru Baykal, Ömer Sönmeza and Aydin Sav*

Department of Medical Pathology, School of Medicine, Yeditepe University, Turkey

*Corresponding Author: Aydin Sav, Department of Medical Pathology, School of Medicine, Yeditepe University, Turkey.

Received: January 31, 2023; Published: February 13, 2023

Abstract

What are the types of pituitary stem cells (PSS)? The pea-sized pituitary gland located at the sella turcica is made up of two main structures: anterior pituitary (adenohypophysis) and posterior pituitary (neurohypophysis) [1]. Adenohypophysis encompasses the stem cell candidates of the gland, which are: folliculostellate cells, follicular cells, marginal zone cells, side population cells, pituitary colony-forming cells, sex-determining region Y (SRY) box 2+ (SOX2+) cells, and glial cell line-derived neurotrophic factor family receptor alpha 2/Prophet of POU domain class 1 transcription factor/Stem cells (GFRa2/Prop1/SCs) [2]. There is compelling evidence on behalf of all of these cell groups being the stem cells (SCs) of the pituitary, but the findings are still controversial, and more research is needed.

References

1. Alatzoglou KS., et al. “Development of the Pituitary Gland”. Comprehensive Physiology 2 (2020): 389-413.
2. Vankelecom H. “Pituitary stem cells drop their mask”. Current Stem Cell Research and Therapy 1 (2012): 36-71.
3. Yoshida S., et al. “Characterization of murine pituitary-derived cell lines Tpit/F1, Tpit/E and TtT/GF”. Journal of Reproduction and Development 4 (2014): 295-303.
4. Sav A. “Pituitary Stem/Progenitor Cells: Their Enigmatic Roles in Embryogenesis and Pituitary Neoplasia - A Review Article. Pituitary Stem/Progenitor Cells: Their Enigmatic Roles in Embryogenesis and Pituitary Neoplasia - A Review Article (2014).
5. Laporte E., et al. “Pituitary Remodeling Throughout Life: Are Resident Stem Cells Involved?” Frontiers in Endocrinology (Lausanne) 11 (2021): 604519.
6. Nys C and Vankelecom H. “Pituitary disease and recovery: How are stem cells involved?” Molecular and Cellular Endocrinology 525 (2021): 111176.
7. Vankelecom H. “Pituitary Stem Cells: Quest for Hidden Functions. 2016 Jul 27. In: Pfaff D, Christen Y, editors”. Stem Cells in Neuroendocrinology. Cham (CH): Springer (2016).
8. Le Tissier PR., et al. “A New Perspective on Regulation of Pituitary Plasticity: The Network of SOX2-Positive Cells May Coordinate Responses to Challenge”. Endocrinology8 (2022): bqac089.
9. Russell JP., et al. “Pituitary stem cells produce paracrine WNT signals to control the expansion of their descendant progenitor cells”. Elife 10 (2021): e59142.
10. Russell JP., et al. “Basic Research Advances on Pituitary Stem Cell Function and Regulation”. Neuroendocrinology2 (2018): 196-203.
11. Gonzalez-Meljem JM., et al. “Stem cell senescence drives age-attenuated induction of pituitary tumours in mouse models of paediatric craniopharyngioma”. Nature Communications 1 (2017): 1819.
12. Xekouki P., et al. “Non-secreting pituitary tumours characterised by enhanced expression of YAP/TAZ”. Endocrine-Related Cancer 1 (2019): 215-225.
13. St John MA., et al. “Mice deficient of Lats1 develop soft-tissue sarcomas, ovarian tumours and pituitary dysfunction”. Nature Genetics 2 (1999): 182-186.
14. Lara-Velazquez M., et al. “Stem cell therapy and its potential role in pituitary disorders”. Current Opinion in Endocrinology, Diabetes and Obesity4 (2017): 292-300.
15. Cox B., et al. “Organoids from pituitary as a novel research model toward pituitary stem cell exploration”. Journal of Endocrinology 2 (2019): 287-308.
16. Camilletti MA., et al. “From Pituitary Stem Cell Differentiation to Regenerative Medicine”. Frontiers in Endocrinology (Lausanne) 11 (2021): 614999.
17. Kasai T., et al. “Hypothalamic Contribution to Pituitary Functions Is Recapitulated In vitro Using 3D-Cultured Human iPS Cells”. Cell Reports 1 (2020): 18-24. e5.
18. Matsumoto R., et al. “Congenital pituitary hypoplasia model demonstrates hypothalamic OTX2 regulation of pituitary progenitor cells”. Journal of Clinical Investigation 2 (2020): 641-654.

Citation

Citation: Aydin Sav., et al. “Perspectives in Pituitary Stem Cells: Their Biologic Properties in Pituitary Diseases, Latest Approaches, and Future Aspects". Acta Scientific Neurology 6.3 (2023): 23-25.

Copyright

Copyright: © 2023 Aydin Sav., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.