Perspectives in Pituitary Stem Cells: Their Biologic Properties in Pituitary Diseases,
Latest Approaches, and Future Aspects
Duru Baykal, Ömer Sönmeza and Aydin Sav*
Department of Medical Pathology, School of Medicine, Yeditepe University, Turkey
*Corresponding Author: Aydin Sav, Department of Medical Pathology, School of Medicine, Yeditepe University, Turkey.
Received:
January 31, 2023; Published: February 13, 2023
Abstract
What are the types of pituitary stem cells (PSS)? The pea-sized pituitary gland located at the sella turcica is made up of two main structures: anterior pituitary (adenohypophysis) and posterior pituitary (neurohypophysis) [1]. Adenohypophysis encompasses the stem cell candidates of the gland, which are: folliculostellate cells, follicular cells, marginal zone cells, side population cells, pituitary colony-forming cells, sex-determining region Y (SRY) box 2+ (SOX2+) cells, and glial cell line-derived neurotrophic factor family receptor alpha 2/Prophet of POU domain class 1 transcription factor/Stem cells (GFRa2/Prop1/SCs) [2]. There is compelling evidence on behalf of all of these cell groups being the stem cells (SCs) of the pituitary, but the findings are still controversial, and more research is needed.
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