Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Case Report Volume 6 Issue 2

Toxic Leukoencephalopathy Presenting with Neuropsychiatric Manifestations-A Case Report

Harshitha V Handral1 and Madhusudhan Shivappa2

1Resident, Department of Psychiatry, Bangalore Medical College and Research Institute, India
2Associate Professor, Department of Psychiatry, Bangalore Medical College and Research Institute, India

*Corresponding Author: Dr. Madhusudhan Shivappa, Associate Professor, Department of Psychiatry, Bangalore Medical College and Research Institute, India.

Received: November 18, 2022; Published: January 20, 2022


A 70-year-old male, with alcohol and nicotine dependence presented to casualty in a state of altered consciousness after accidental overnight LPG gas exposure. Over the next 2 weeks he had residual fatigability, discontinued his work, and remained abstinent from substances henceforth, otherwise was asymptomatic. In the 3rd week, he started to develop confusion, disorientation, irritability, urinary incontinence, decreased self-care, aggression and reduced oral intake. Over the next 2 days developed catatonic symptoms. Routine investigations found within normal limits. MRI-Brain revealed features suggestive of toxic leukoencephalopathy. Minimal improvement in catatonic symptoms was noted with Lorazepam. Nootropics, Steroids, Antioxidants and Multivitamins were added along with supportive care. Over the subsequent two weeks completely was bedbound, his Glasgow coma scale score deteriorated to E4V2M3. He succumbed to death.

Keywords: Toxic Encephalopathy; Liquid Petroleum Gas; Neuropsychiatric Manifestations


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Citation: Harshitha V Handral and Madhusudhan Shivappa. “Toxic Leukoencephalopathy Presenting with Neuropsychiatric Manifestations- A Case Report". Acta Scientific Neurology 6.2 (2023): 16-19.


Copyright: © 2023 Harshitha V Handral and Madhusudhan Shivappa. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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