Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Research Article Volume 5 Issue 11

Event Related Potentials and its Correlation with Cognitive Decline in Multiple Sclerosis Patients in a Tertiary Care Hospital in New Delhi

KK Jindal1 and Harsh Bhardwaj2

1Senior Consultant Neurologist, Max Superspeciality Hospital, Shalimar Bagh, New Delhi, India
2Neurologist, Aakash Healthcare Superspeciality Hospital, New Delhi, India

*Corresponding Author: Harsh Bhardwaj, Neurologist, Aakash Healthcare Superspeciality Hospital, New Delhi, India.

Received: August 16, 2022; Published: November 05, 2022


Introduction: Multiple sclerosis is one of the common disabling neurological disorders. Cognitive deficits are emerging as the main cause of change in professional and social life. The P-300 event related potentials are delayed in latency in various disorders characterised by dementia. Here, we study the correlation of the event related potentials with cognitive decline in MS patients.

Aims and Objectives: To evaluate patients with multiple sclerosis clinically and electro physiologically measuring event related potentials in respect of latency and amplitude and to co-relate it with cognitive decline.

Material and Methods: 30 consecutive cases of multiple sclerosis were included in the study. All the patients were subjected to detailed neurological examination with MMSE, dementia score of Blessed et al and information-memory - concentration test. All the neurophysiologic tests were performed. Results: The mean MMSE score was 26.16 (P < 0.01). The mean dementia score was 5.43 ± 4.0 (P < 0.01). P300 latency was significantly (P < 0.01) higher in patients as comparison to control subjects. Dementia scores showed significant correlation with P300 latency when partially correlated.

Conclusions: Abnormal prolongation of P300 ERP latency had a high correlation with cerebral white matter involvement and with impaired cognition in multiple sclerosis.

Significance: The paper helps in identifying cognitive decline as a symptom of MS and strengthens how electrophysiology methods could be used to identify sub-clinical cognitive decline.

Keywords:Event Related; Potentials; Correlation; Cognitive Decline; Multiple Sclerosis


  1. Stephen M Rao., et al. “Cognitive dysfunction in multiple sclerosis. Frequency, patterns; and prediction”. Neurology 41 (1991): 685-691.
  2. Nocentini., et al. “Patterns of cognitive impairment in secondary progressive stable phase of multiple sclerosis. Correlations with MRI findings”. European Neurology 45 (2001): 11-18.
  3. Khowrt SJ., et al. “Longitudinal MRI in multiple sclerosis: correlation between disability and lesion burden”. Neurology 44 (1994): 2120-2124.
  4. Newton MR., et al. “Cognitive event related potentials in multiple sclerosis”. Brain 112 (1989): 1637-1660.
  5. Jonathan C Aminoff and Douglas S Goodin. “Long latency Cerebral Event related Potentials in multiple sclerosis”. Journal of Clinical Neurophysiology 18.4 (2001): 372-377.
  6. Lawrence H honing., et al. “Event related potential P-300 in multiple sclerosis”. Archives of Neurology 49 (1992): 44-50.
  7. Tourtellotte WW., et al. “Use of P300 and a dementia rating scale in the evaluation of cognitive dysfunction in MS”. Acta Neurologica Scandinavica 101.1 (1984): 32-34.
  8. Triantafyllou NI., et al. “Cognition in relapsing-remitting multiple sclerosis: a multichannel event-related potential (P300) study”. Acta Neurologica Scandinavica 85 (1992): 10-13.
  9. Honig LS., et al. “Magnetic resonance imaging, cognitive impairment, and the P300 event relayed potential in patients with multiple sclerosis”. Neurology 36.1 (1986): 157.
  10. Johnson R. “Scalp- recorded P300 activity in patients following unilateral temporal lobectomy”. Brain 111 (1998): 1517-1529.
  11. Filippi M., et al. “Changes in the normal appearing brain tissue and cognitive impairment in multiple sclerosis”. JNNP 68 (2000): 157-161.
  12. W Ian McDonald., et al. “Recommended Diagnostic Criteria for Multiple sclerosis: Guidelines from the international panel on the Diagnosis of Multiple Sclerosis”. Annals of Neurology 50 (2001): 121-127.
  13. Kurtzke JF. “Rating neurological impairment in multiple sclerosis an expanded disability status scale (EDSS)”. Neurology 33 (1983): 1444-1452.
  14. Folstein MF., et al. “Mini mental status Examination: A Practical method of grading the mental state of patients for the clinician”. Journal of Psychiatric Research 12 (1975): 189-198.
  15. Heaton RK., et al. “Neuropsychological findings in relapsing-remitting and chronic-progressive multiple sclerosis”. Journal of Consulting and Clinical Psychology 53 (1985): 103-110.
  16. Shulman KL., et al. “Clock drawing and dementia in the community, a longitudinal study”. International Journal of Geriatric Psychiatry (1993): 487-496.
  17. Runge VM., et al. “Magnetic resonance imaging of multiple sclerosis: a study of pulsed technique efficacy”. AJR American Journal of Roentgenology 148 (1984): 1015-1026.
  18. Honig LS., et al. “Event-related potential P300 in multiple sclerosis. Relation to magnetic resonance imaging and cognitive impairment”. Archives of Neurology 49.1 (1992): 44-50.
  19. Syal P., et al. “Clinical profile of multiple sclerosis in north-west India”. Neurology India 47 (1999): 12-17.
  20. Chopra JS., et al. “Multiple sclerosis in North-west India”. Acta Neurologica Scandinavica 62 (1980): 312-321.
  21. Singhal BS. “Multiple sclerosis and related demyelinating disorders in Indian context”. Neurology India 35 (1987): 1-12.
  22. Bhatia M., et al. “Multiple sclerosis in India: AIIMS experience”. Journal of the Association of Physicians of India 44 (1996): 765-67.
  23. Yu YL., et al. “Multiple sclerosis amongst Chinese in Hong Kong”. Brain 112 (1989): 1445-1467.
  24. Ai KZ and Zhao CX. “The clinical significance of CSF oligoclonal bands detection in multiple sclerosis and other neurological disorders”. Chinese Journal of Neurology and Psychiatry 16 (1983): 285-288.
  25. Tabira T., et al. “CSF immunoglobulin and virus antibody in Japanese multiple sclerosis: a comparative study”. In: Multiple sclerosis: East and West. Kuroiwa Y and Kurland LT. (Eds.) Kyushu University Press Fukuoka, Japan 223-233.
  26. Polich J., et al. “P300 in multiple sclerosis: a preliminary report”. International Journal of Psychophysiology 12 (1992): 153-163.
  27. Gil R., et al. “Event-related auditory evoked potentials and multiple sclerosis”. Electroencephalography and Clinical Neurophysiology 88 (1993): 182-187.
  28. Yoram Barak., et al. “Screening for early cognitive impairment in multiple sclerosis patients using the clock drawing test”. Journal of Clinical Neuroscience 9.6 (2002): 629-632.


Citation: KK Jindal and Harsh Bhardwaj. “Event Related Potentials and its Correlation with Cognitive Decline in Multiple Sclerosis Patients in a Tertiary Care Hospital in New Delhi". Acta Scientific Neurology 5.12 (2022): 03-11.


Copyright: © 2022 KK Jindal and Harsh Bhardwaj. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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