Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Perspective Volume 5 Issue 11

Reward Deficiency Syndrome Model of Addiction Psychiatry: Everywhere, Everything, and All at Once

Kenneth Blum1-5*, Abdalla Bowirrat6, Mauro Ceccanti7, Catherine Dennen8, Thomas McLaughlin3, David Baron1, Igor Elman9,10, Eric R Braverman3, Mark S Gold11, Ashim Gupta12, Panayotis K Thanos13, Daniel Gastelu14 and Rajendra D Badgaiyan15,16

1Division of Addiction Research and Education, Center for Mental Health and Sports Psychiatry, Western University of Health Sciences, Pomona, CA, USA

2 Institute of Psychology, ELTE Eötvös Loránd University, Hungary

3Division of Nutrigenomics, The Kenneth Blum Neurogenetic and Behavioral Institute, LLC, Austin, TX, USA

4Department of Psychiatry, University of Vermont, Burlington, VT, USA

5Department of Psychiatry, Wright University Boonshoft School of Medicine, Dayton, OH, USA and Center for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, West Bengal, India

6Department of Molecular Biology, Adelson School of Medicine, Ariel University, Ariel, Israel

7Department of Translational and Precision Medicine, Sapienza University, Rome - Italy

8Department of Family Medicine, Jefferson Health Northeast, Philadelphia, PA, USA

9Cambridge Health Alliance, Harvard Medical School, Cambridge, MA, USA

10Center for Pain and the Brain (PAIN Group), Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Boston

11Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA

12Future Biologics, Lawrenceville, GA, USA

13Behavioral Neuropharmacology and Neuroimaging Laboratory, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA

14International Sports Science Association, Phoenix, AZ, USA

15Department of Psychiatry, South Texas Veteran Health Care System, Audie L. Murphy Memorial VA Hospital, Long School of Medicine, University of Texas Health Science Center, San Antonio, TX, USA

16Department of Psychiatry, MT. Sinai School of Medicine, New York, NY, USA

*Corresponding Author: Kenneth Blum, Division of Addiction Research and Education, Center for Mental Health and Sports Psychiatry, Western University of Health Sciences, Pomona, CA, USA.

Received: July 18,2022; Published: October 12, 2022

Abstract

In the 21st century, the world is experiencing unwanted catastrophic issues that are affecting billions daily, including climate change, politically based hate, war, gun violence, anti-women's rights, COVID, an out-of-control drug epidemic, and a global mental health crisis [1]. Since 2015, the United Nations Office on Drugs and Crime (UNODC), World Health Organization (WHO), and Informal Scientific Network (ISN) have strived to bring the voice of science, as it pertains to addiction medicine, to inform critical discussions at the Commission on Narcotic Drugs (CND), the policymaking body of the United Nations with prime responsibility for drug control matters [2]. The opioid overdose crisis represents an increasingly global challenge, one associated with high rates of morbidity and mortality [3]. The contours of the epidemic have been most extensively documented in North America, but serious situations are developing around the world. Meanwhile, millions of people worldwide suffer from moderate to severe pain without access to opioid analgesics, despite the provisions of the international drug conventions. For these reasons, during the CND's 61st session, the ISN examined the opioid overdose crisis and presented a statement with recommendations for consideration by the CND [4].

References

  1. United Nations Office on Drugs and Crime. “Outcome document of the 2016 United Nations General Assembly special session on the world drug problem”. Vienna: United Nations Office on Drugs and Crime (2016).
  2. Volkow ND., et al. “World Psychiatry” 16 (2017): 213‐214.
  3. World drug report. Vienna: United Nations Office on Drugs and Crime (2018).
  4. United Nations Office on Drugs and Crime. “The International Drug Control Conventions Single Convention on Narcotic Drugs of 1961 as amended by the 1972 Protocol Convention on Psychotropic Substances of 1971 United Nations Convention against Illicit Traffic in Narcotic Drugs and Psychotropic Substances of 1988 with final acts and resolutions”. Vienna: United Nations Office on Drugs and Crime (2013).
  5. Kaplan G., et al. “DNA Epigenetics in Addiction Susceptibility”. Frontiers in Genetics 13 (2022): 806685.
  6. Hagerty SL., et al. “DRD2 methylation is associated with executive control network connectivity and severity of alcohol problems among a sample of polysubstance users”. Addiction Biology 25.1 (2020): e12684.
  7. Gondré-Lewis MC., et al. “Pre-clinical models of reward deficiency syndrome: A behavioral octopus”. Neuroscience and Biobehavioral Reviews 115 (2020): 164-188.
  8. Blum K., et al. “Reward Deficiency Syndrome (RDS) Surprisingly Is Evolutionary and Found Everywhere: Is It "Blowin' in the Wind?” Journal of Personalized Medicine 12.2 (2022): 321.
  9. Ma X., et al. “Evolution of dopamine-related systems: biosynthesis, degradation and receptors”. Journal of Molecular Evolution 71.5-6 (2010): 374-384.
  10. Blum K., et al. “Hatching the behavioral addiction egg: Reward Deficiency Solution System (RDSS)™ as a function of dopaminergic neurogenetics and brain functional connectivity linking all addictions under a common rubric”. Journal of Behavioral Addictions 3.3 (2014): 149-156.
  11. Walters RK., et al. “Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders”. Nature Neuroscience 21.12 (2018): 1656-1669.
  12. Casey BJ., et al. “DSM-5 and RDoC: progress in psychiatry research?” Nature Reviews Neuroscience 14.11 (2013): 810-814.
  13. Noble D and Neo-Darwinism. “The modern synthesis and selfish genes: are they of use in physiology?” The Journal of Physiology 589.Pt 5 (2011): 1007-1015.
  14. Álvarez-Machicotes Ó., et al. “On the Role of Artificial Intelligence in Genomics to Enhance Precision Medicine”. Pharmacogenomics and Personalized Medicine 13 (2020): 105-119.
  15. Hyman SE. The daunting polygenicity of mental illness: making a new map”. Philosophical Transactions of the Royal Society B: Biological Sciences 373.1742 (2018): 20170031.
  16. Blum K., et al. “Biotechnical development of genetic addiction risk score (GARS) and selective evidence for inclusion of polymorphic allelic risk in substance use disorder (SUD)”. Journal of Systems and Integrative Neuroscience 6.2 (2020): 10.
  17. Moran M., et al. “High Genetic Addiction Risk Score (GARS) in Chronically Prescribed Severe Chronic Opioid Probands Attending Multi-Pain Clinics: an Open Clinical Pilot Trial”. Molecular Neurobiology 58.7 (2021): 3335-3346.
  18. Blum K., et al. “Exploration of Epigenetic State Hyperdopaminergia (Surfeit) and Genetic Trait Hypodopaminergia (Deficit) During Adolescent Brain Development”. Current Psychopharmacology 10 (2021): 10.
  19. Gold MS., et al. “Neurological correlates of brain reward circuitry linked to opioid use disorder (OUD): Do homo sapiens acquire or have a reward deficiency syndrome?” Journal of the Neurological Sciences 418 (2020): 117137.
  20. Blum K., et al. “In Search of Reward Deficiency Syndrome (RDS)-free Controls: The "Holy Grail" in Genetic Addiction Risk Testing”. Current Psychopharmacology 9.1 (2020): 7-21.

Citation

Citation: Kenneth Blum., et al. “Reward Deficiency Syndrome Model of Addiction Psychiatry: Everywhere, Everything, and All at Once". Acta Scientific Neurology 5.11 (2022): 36-42.

Copyright

Copyright: © 2022 Kenneth Blum., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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