Jennifer Gantzer*, Daniel Strauss and Mark Wieland

Department of Clinical Sciences, National University of Health Sciences, USA

*Corresponding Author: Jennifer Gantzer, Department of Clinical Sciences, National University of Health Sciences, USA.

Received: September 14, 2022; Published: October 05, 2022

Abstract

Low-level laser (light) therapy, LLLT, is a therapeutic application of light delivered as photons. The ability of absorbed light able to induce physiological effects is known as photobiomodulation. LLLT photobiomodulation is well-documented to provide clinical benefits of improved rates of healing attributed to anti-inflammatory effects, decreased pain, and enhanced tissue regeneration. These clinical outcomes correlate to the mechanism of action of LLLT’s photobiomodulation effects of increased generation of ATP and the ability to modulate inflammatory signaling molecules known to influence rapid and optimal tissue healing repair and regeneration. The clinical benefits of 635 nm LLLT is highlighted from a molecular mechanism of action perspective.

Keywords: LLLT; Cold Laser; 635 nm; Photobiomodulation

References

1. Huang YY., et al. “Biphasic dose response in low level light therapy”. Dose Response4 (2009): 358-383.
2. Chung H., et al. “The nuts and bolts of low-level laser (light) therapy”. Annual Review of Biomedical Engineering 2 (2012): 516-533.
3. Huang YY., et al. “Biphasic dose response in low level light therapy - an update”. Dose Response4 (2011): 602-618.
4. Luo L., et al. “Effects of low-level laser therapy on ROS homeostasis and expression of IGF-1 and TGF-β1 in skeletal muscle during the repair process”. Lasers in Medical Science 3 (2013): 725-734.
5. Lim W., et al. “Anti-inflammatory effect of 635 nm irradiations on in vitro direct/indirect irradiation model”. Journal of Oral Pathology and Medicine 2 (2015): 94-102.
6. Liguori I., et al. “Oxidative stress, aging, and diseases”. Clinical Interventions in Aging 13 (2018): 757-772.
7. Chaudary S., et al. “In vitro effects of 635 nm photobiomodulation under hypoxia/reoxygenation culture conditions”. Journal of Photochemistry and Photobiology B 209 (2020): 111935.
8. Nammour S., et al. “Photobiomodulation Therapy vs. Corticosteroid for the Management of Erosive/Ulcerative and Painful Oral Lichen Planus. Assessment of Success Rate during One-Year Follow-Up: A Retrospective Study”. Healthcare (Basel)9 (2021): 1137.
9. Kilík R., et al. “Effect of equal daily doses achieved by different power densities of low-level laser therapy at 635 nm on open skin wound healing in normal and diabetic rats”. BioMed Research International 2014 (2014): 269253.
10. Calin MA., et al. “Fractionated Irradiation in Photobiomodulation Therapy of Ankle Sprain”. American Journal of Physical Medicine and Rehabilitation 8 (2019): 692-698.
11. Vasilenko T., et al. “The effect of equal daily dose achieved by different power densities of low-level laser therapy at 635 and 670 nm on wound tensile strength in rats: a short report”. Photomedicine and Laser Surgery 2 (2010): 281-283.
12. Gupta A., et al. “Effect of red and near-infrared wavelengths on low-level laser (light) therapy-induced healing of partial-thickness dermal abrasion in mice”. Lasers in Medical Science 1 (2014): 257-265.
13. Calin MA and Botea S. “In vivo comparison of simple and double-fractionated low- level laser irradiation schemes on the healing of rat skin lesions”. Photomedicine and Laser Surgery 2 (2010): 245-2250.
14. Poorpezeshk N., et al. “Early Low-Level Laser Therapy Improves the Passive Range of Motion and Decreases Pain in Patients with Flexor Tendon Injury”. Photomedicine and Laser Surgery 10 (2018): 530-535.
15. Rocca JP., et al. “Effect of laser irradiation on aphthae pain management: A four different wavelengths comparison”. Journal of Photochemistry and Photobiology B 189 (2018): 1-4.
16. Amer M., et al. “Results of low-level laser therapy in the treatment of hair growth: An Egyptian experience”. Dermatologic Therapy 3 (2021): e14940.
17. Kumar V., et al. “Robbins basic pathology”. Tenth edition. Kumar V, Abbas AK, Aster JC, editors. Philadelphia, Pennsylvania: Elsevier (2018).
18. “XLR8 Handheld Cold Laser”.

Citation

Citation: Jennifer Gantzer., et al. “Clinical Benefits of Photobiomodulation using a 635 nm of Low-Level Laser Therapy (LLLT) from a Mechanism of Action Perspective". Acta Scientific Neurology 5.11 (2022): 10-14.

Copyright

Copyright: © 2022 Jennifer Gantzer., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.