Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Review Article Volume 5 Issue 10

Biopolymer Mediated Macrophage Polarization: A Method of ALS (Amyotropic Lateral Sclerosis) Control

Ashok Chakraborty* and Anil Diwan

Department of Cell Biology, AllExcel, Inc, Shelton, CT, USA

*Corresponding Author: Ashok Chakraborty, Department of Cell Biology, AllExcel, Inc, Shelton, CT, USA.

Received: July 19,2022; Published: September 15, 2022

Abstract

Amyotrophic lateral sclerosis (ALS) is a motor neuron disease (MND) with the worst prognosis with 4-5 years. Both upper and lower motor neurons in the cortex and in the brainstem spinal cord are affected. No effective treatments are available yet. Furthermore, in 10-14% ALS cases are involved with genetic defects, while about 90% cases are reported as sporadic. In fact, immune dysregulation causes the activation of inflammatory cells that augment the ALS disease progression. M2 macrophages have immunosuppressive activity, produces high level of anti-inflammatory cytokine IL-10 and mediates tissue repair, noticed in diabetic and nephrotic mice. The M1-type of macrophages (MΦs), are pro-inflammatory and causes lung disease, like ALI (acute lung injury) and ARDS (acute respiratory distress syndrome). Recently, it was demonstrated that M2-type of MΦs are immunosuppressive, can induce boost Tregs (Regulatory T cells), and serves as a candidate for immune-cell-based therapy for ALS.

In this review we drew a hypothetical connection, supported by evidence, between nanoparticles medicated MFs polarization to M2 type and targeting to deliver in the brain for ALS control.

Keywords: ALS Disease; Motor Neuron Defects; MQ Polarization; Nanobiopolymer

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Citation

Citation: Ashok Chakraborty and Anil Diwan. “Biopolymer Mediated Macrophage Polarization: A Method of ALS (Amyotropic Lateral Sclerosis) Control”. Acta Scientific Neurology 5.10 (2022): 19-24.

Copyright

Copyright: © 2022 Ashok Chakraborty and Anil Diwan. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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