Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Research Article Volume 5 Issue 8

Non-motor Dysfunction in Idiopathic Parkinson’s Disease - An Indian Perspective

Sushil Garg, Kiran Bala, Hardeep Malhotra, Aldrin Anthony and Siddharth Maheshwari*

Department of Neurology, Institute of Human Behavior and Allied Sciences, New Delhi, India

*Corresponding Author: Siddharth Maheshwari, Assistant Professor, Department of Neurology, Institute of Human Behavior and Allied Sciences, New Delhi, India.

Received: June 08, 2022; Published: July 06, 2022


Parkinson Disease (PD) was described by James Parkinson in his classic in 1817. Recently there has been a tremendous progress in our understanding of this complex and fascinating neurological disorder. It not only manifest motor symptoms but there is a whole range of non-motor features, including cognitive, psychiatric and autonomic impairments. The non-motor dysfunction of PD is an important cause of morbidity and increases the burden of the disease far beyond that caused by the classical motor symptoms..

Keywords: Parkinson Disease (PD); Parkinson Disease Dementia (PDD); Depression

  1. Foltynie T., et al. “The cognitive ability of an incident cohort of Parkinson’s disease patients in the UK, The CamPaIGN study”. Brain 127 (2004): 1-11.
  2. Richard IH., et al. “Anxiety and Parkinson’s disease”. Journal of Neuropsychiatry and Clinical Neurosciences 8 (1996): 383-392.
  3. Walsh K and Bennett G. “Parkinson’s disease and Anxiety”. Postgraduate Medical Journal 77 (2001): 89-93.
  4. Nissenbaum H., et al. “Mood swings associated with the ‘on-off’ phenomenon in Parkinson’s disease, A register based study”. Acta Psychiatrica Scandinavica 17 (1987): 899-904.
  5. Witjas T., et al. “Non-motor fluctuations in Parkinson’s disease: Frequent and disabling”. Neurology 59 (2002): 408-413.
  6. Braak H., et al. “Idiopathic Parkinson’s Disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen”. Journal of Neural Transmission 110 (2003): 517-536.
  7. Berendse HW and Groenewegen HJ. “Organization of the thalamostriatal projections in the rat, with a special emphasis on the ventral striatum”. The Journal of Comparative Neurology 299 (1990): 187-228.
  8. Singer C., et al. “Sexual functions in patients with Parkinson’s disease”. Journal of Neurology, Neurosurgery, and Psychiatry10 (1990): 942.
  9. Visser M., et al. “Assessment of autonomic dysfunction in Parkinson’s disease: The SCOPA- AUT”. Movement Disorder11 (2004): 1306-1312.
  10. Susan Spear Basset. “Cognitive impairment in Parkinson’s disease”. Primary Psychiatry 12 (2005): 50-55.
  11. Sullivan EV., et al. “Different cognitive profiles on standard behavioural tests in Parkinson’s disease and Alzheimer’s disease”. Journal of Clinical and Experimental Neuropsychology 6 (1989): 94-109.
  12. Goldman WP., et al. “Cognitive and motor functioning in Parkinson’s disease: subjects with or without questionable dementia”. Archives of Neurology 55 (1998): 674-80.
  13. Gross RG., et al. “Cognitive impairment in Parkinson’s disease and Dementia with Lewy Bodies: A spectrum of disease”. Neurosignals 16 (2008): 24-34.
  14. Aarsland D., et al. “Prevalence and characteristics of dementia in Parkinson’s disease: an 8 year prospective study”. Archives of Neurology3 (2003): 387-392.
  15. Marinus J., et al. “Assessment of cognition in Parkinson’s disease”. Neurology 61 (2003): 1222-1228.
  16. Tandberg E., et al. “The occurrence of depression in Parkinson’s disease: a community based study”. Archives of Neurology 53 (1996): 175-179.
  17. Okun MS and Watts RL. “Depression associated with Parkinson’s disease”. Neurology 58 (2002): S63-70.
  18. Cummings JL. “Depression and Parkinson’s disease: a review”. American Journal of Psychiatry 149 (1992): 443-454.
  19. Weinturb D., et al. “Recognition and treatment of depression in Parkinson’s disease”. Journal of Geriatric Psychiatry and Neurology 16 (2003): 178-183.
  20. Shulman Lm., et al. “Non-recognition of depression and other non motor symptoms in Parkinson’s disease”. Parkinsonism and Related Disorders 8 (2002): 193-197.
  21. Schrag A. “Quality of life and depression in Parkinson’s disease”. Journal of Neurology Science 248 (2006): 151-157.
  22. Paus S., et al. “Sleep attacks, daytime sleepiness, and dopamine agonists in Parkinson’s disease”. Movement Disorder 18 (2003): 659-667.
  23. Aarsland D., et al. “Neuropsychiatric symptoms in patients with Parkinson’s disease and dementia: frequency, profile and associated care giver stress”. Journal of Neurology, Neurosurgery, and Psychiatry 78 (2007): 36-42.
  24. Verbaan D., et al. “Patient-reported autonomic symptoms in Parkinson’s disease”. Neurology 69 (2007): 333-341.
  25. Ueki A and Otsuka M. “Life style risks of Parkinson’s disease: association between decreased water intake and constipation”. Journal of Neurology 251 (2004): 1118-1123.
  26. Abbott RD and Petrovich H. “Frequency of bowel movements and the future risk of Parkinson’s disease”. Neurology 57 (2001): 456-462.
  27. Negre –Pages L and Bouhassira D. “Chronic pain in Parkinson’s disease: the cross sectional French DoPaMiP survey”. Movement Disorder 23 (2008): 1361-1369.
  28. Defazio G and Fabbrini G. “Pain as a non motor symptoms of Parkinson’s disease”. Archives of Neurology 65 (2008): 1191-1194.
  29. Weintraub D., et al. “Dopamine Agonist Use is associated with Impulse Control Disorders in Parkinson’s disease”. Archives of Neurology7 (2006): 969-973.


Citation: Siddharth Maheshwari., et al. “Non-motor Dysfunction in Idiopathic Parkinson’s Disease - An Indian Perspective". Acta Scientific Neurology 5.8 (2022): 10-18.


Copyright: © 2022 Siddharth Maheshwari., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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