Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Short Communication Volume 5 Issue 7

The Link between Cognitive Deficits and White Matter Injury in Preterms

Christian Zammit1 and Mario Valentino2*

1Department of Anatomy, University of Malta, Msida, Malta
2Department of Physiology and Biochemistry, University of Malta, Msida, Malta

*Corresponding Author: Mario Valentino, Department of Physiology and Biochemistry, University of Malta, Msida, Malta.

Received: May 23,2022; Published:


Preterm cerebral white matter injury (WMI) frequently encompasses hypoxic–ischemic lesions such as periventricular leukomalacia (PVL) and hypoxic–ischemic encephalopathy (HIE). These infants are extremely vulnerable to brain injury and are at high risk of developing motor and cognitive abnormalities at later stages in life.

Although preoligodendrocytes (preOLs) have long been regarded as the hallmark of perinatal white matter injury [1], we have previously reported that late pre-myelinating axons having initiated diameter expansion and expressing clusters of functional voltage-gated calcium channels, are equally principal targets for injury during heightened periods of selective vulnerability to hypoxia-ischemia.  By contrast, axons yet to enter this developmental window, or which have already initiated myelination, have a much higher ischemic tolerance [2]. The burden of WMI in a given region is thus likely to be influenced by the complement of late pre-myelinating axons and preOLs in the affected white matter structures. These findings suggest that damage to developing axons is a major, but previously underappreciated component of perinatal WMI and which as to date remains without any cure [2].


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Citation: Christian Zammit and Mario Valentino. “The Link between Cognitive Deficits and White Matter Injury in Preterms". Acta Scientific Neurology 5.7 (2022): 21-22.


Copyright: © 2022 Christian Zammit and Mario Valentino. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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