Rajniti Prasad1*, Shreya Mishra2, Ankur Singh3, Deepika Joshi4, Om Prakash Mishra5 and Shrawin Kumar Singh6
1Professor Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh
2Junior Resident, Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh
3Professor, Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh
4Professor, Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh
5Professor, Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh
6Associate professor, Department of Otorhinolaryngology, Heritage Institute of Medical Sciences, Varanasi, Uttar Pradesh
*Corresponding Author: Rajniti Prasad, Professor Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh.
Received: March 25, 2022; Published: April 29, 2022
Background: Guillian Barre syndrome (GBS) is the most common cause of acute onset flaccid paralysis presenting at the tertiary center in the post-polio eradication era. There is regional variation in the presentation and outcome of GBS worldwide.
Objective: We aimed to analyze clinical presentation and short term outcomes of GBS patients admitted to our center.
Methods: All children (1-14 years) of age with a diagnosis of GBS were enrolled in the study. Data were entered in a pre-formed format. Nerve conduction study, Cerebrospinal fluid examination, and other relevant investigations were done. Children received intravenous immunoglobulins (1 gram/kg) over 2 days. Respiratory support was given to children who were required. Functional outcome (Hughes score) were measured at end of 6 months
Results: There were seventy-six patients enrolled in the study over the study period of June 2017 to December 2020. The mean age of the study population was 76.5 ± 45.26 months. There were 49 males. The mean duration of hospital stay was 5.84 ± 2.28 days. Quadriparesis, paraparesis, and cranial nerve involvement were the most common clinical presentation in the study population. AIDP was the most common electrophysiological subtype in this cohort. Mechanical ventilation was required in 4 patients. Fifty-eight patients showed good recovery at the end of 6 months. Ten patients had residual weakness in either upper limb or lower limb at end of the follow-up period of 6 months. The need for mechanical ventilation was associated with poor outcomes at end of 6 months.
Conclusion: The majority of patients showed good functional recovery at end of 6 months follow up. AIDP was the most common electrophysiological subtype in this region, highlighting the regional variation. The need for mechanical ventilation was associated with poor recovery.
Keywords: Guillain; Barre Syndrome; Children; Outcome; India
Citation: Rajniti Prasad., et al. “Profile of Children with Guillain Barre Syndrome from tertiary Centre in Eastern Uttar Pradesh: a Prospective Observational Study". Acta Scientific Neurology 5.5 (2022): 66-74.
Copyright: © 2022 Rajniti Prasad., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.