Rajniti Prasad¹*, Shreya Mishra², Ankur Singh³, Deepika Joshi⁴, Om Prakash Mishra⁵ and Shrawin Kumar Singh⁶

¹Professor Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh
²Junior Resident, Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh
³Professor, Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh
⁴Professor, Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh
⁵Professor, Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh
⁶Associate professor, Department of Otorhinolaryngology, Heritage Institute of Medical Sciences, Varanasi, Uttar Pradesh

*Corresponding Author: Rajniti Prasad, Professor Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh.

Received: March 25, 2022; Published: April 29, 2022

Abstract

Background: Guillian Barre syndrome (GBS) is the most common cause of acute onset flaccid paralysis presenting at the tertiary center in the post-polio eradication era. There is regional variation in the presentation and outcome of GBS worldwide.

Objective: We aimed to analyze clinical presentation and short term outcomes of GBS patients admitted to our center.

 Methods: All children (1-14 years) of age with a diagnosis of GBS were enrolled in the study. Data were entered in a pre-formed format. Nerve conduction study, Cerebrospinal fluid examination, and other relevant investigations were done. Children received intravenous immunoglobulins (1 gram/kg) over 2 days. Respiratory support was given to children who were required. Functional outcome (Hughes score) were measured at end of 6 months

Results: There were seventy-six patients enrolled in the study over the study period of June 2017 to December 2020. The mean age of the study population was 76.5 ± 45.26 months. There were 49 males. The mean duration of hospital stay was 5.84 ± 2.28 days. Quadriparesis, paraparesis, and cranial nerve involvement were the most common clinical presentation in the study population. AIDP was the most common electrophysiological subtype in this cohort. Mechanical ventilation was required in 4 patients. Fifty-eight patients showed good recovery at the end of 6 months. Ten patients had residual weakness in either upper limb or lower limb at end of the follow-up period of 6 months. The need for mechanical ventilation was associated with poor outcomes at end of 6 months.

Conclusion: The majority of patients showed good functional recovery at end of 6 months follow up. AIDP was the most common electrophysiological subtype in this region, highlighting the regional variation. The need for mechanical ventilation was associated with poor recovery.

Keywords: Guillain; Barre Syndrome; Children; Outcome; India

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Citation

Citation: Rajniti Prasad., et al. “Profile of Children with Guillain Barre Syndrome from tertiary Centre in Eastern Uttar Pradesh: a Prospective Observational Study". Acta Scientific Neurology 5.5 (2022): 66-74.

Copyright

Copyright: © 2022 Rajniti Prasad., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.