Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Research Article Volume 5 Issue 5

Profile of Children with Guillain Barre Syndrome from tertiary Centre in Eastern Uttar Pradesh: a Prospective Observational Study

Rajniti Prasad1*, Shreya Mishra2, Ankur Singh3, Deepika Joshi4, Om Prakash Mishra5 and Shrawin Kumar Singh6

1Professor Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh
2Junior Resident, Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh
3Professor, Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh
4Professor, Department of Neurology, Institute of Medical Sciences, Banaras Hindu University, Uttar Pradesh
5Professor, Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh
6Associate professor, Department of Otorhinolaryngology, Heritage Institute of Medical Sciences, Varanasi, Uttar Pradesh

*Corresponding Author: Rajniti Prasad, Professor Department of Paediatrics, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh.

Received: March 25, 2022; Published: April 29, 2022

Abstract

Background: Guillian Barre syndrome (GBS) is the most common cause of acute onset flaccid paralysis presenting at the tertiary center in the post-polio eradication era. There is regional variation in the presentation and outcome of GBS worldwide.

Objective: We aimed to analyze clinical presentation and short term outcomes of GBS patients admitted to our center.

 Methods: All children (1-14 years) of age with a diagnosis of GBS were enrolled in the study. Data were entered in a pre-formed format. Nerve conduction study, Cerebrospinal fluid examination, and other relevant investigations were done. Children received intravenous immunoglobulins (1 gram/kg) over 2 days. Respiratory support was given to children who were required. Functional outcome (Hughes score) were measured at end of 6 months

Results: There were seventy-six patients enrolled in the study over the study period of June 2017 to December 2020. The mean age of the study population was 76.5 ± 45.26 months. There were 49 males. The mean duration of hospital stay was 5.84 ± 2.28 days. Quadriparesis, paraparesis, and cranial nerve involvement were the most common clinical presentation in the study population. AIDP was the most common electrophysiological subtype in this cohort. Mechanical ventilation was required in 4 patients. Fifty-eight patients showed good recovery at the end of 6 months. Ten patients had residual weakness in either upper limb or lower limb at end of the follow-up period of 6 months. The need for mechanical ventilation was associated with poor outcomes at end of 6 months.

Conclusion: The majority of patients showed good functional recovery at end of 6 months follow up. AIDP was the most common electrophysiological subtype in this region, highlighting the regional variation. The need for mechanical ventilation was associated with poor recovery.

Keywords: Guillain; Barre Syndrome; Children; Outcome; India

References

  1. Korinthenberg R and Schulte Monting J. “Natural history and treatment effects in Guillain-Barre syndrome: a multicentre study”. Archives of Disease in Childhood 74 (1996): 281-287.
  2. Hahn AF. “Guillain-Barré syndrome”. Lancet9128 (1998): 635-641.
  3. Hughes RA and Rees JH. “Clinical and epidemiological features of Guillain-Barré syndrome”. The Journal of Infectious Diseases 176 (1997): S92-S98.
  4. Asbury AK. “New concepts of Guillain-Barre syndrome”. Journal of Child Neurology 15 (2000): 183-191.
  5. Abd-Allah SA., et al. “Intravenous immunoglobulin as therapy for pediatric Guillain- Barré syndrome”. Journal of Child Neurology 12 (1997): 376-380.
  6. Kanra G., et al. “Intravenous immunoglobulin treatment in children with Guillain-Barr syndrome. European Journal of Paediatric Neurology 1 (1997): 7-12
  7. Yadav S., et al. “Guillain-Barre syndrome in North Indian children: Clinical and serial electrophysiological features”. Neurology India 67 (2019): 724‐727.
  8. Gupta PK., et al. “How Different is AMAN from AIDP in Childhood GBS? A Prospective Study from North India”. Indian Journal of Pediatrics 86 (2019): 329‐334.
  9. Kalita J., et al. “Prospective comparison of acute motor axonal neuropathy and acute inflammatory demyelinating polyradiculoneuropathy in 140 children with Guillain-Barré syndrome in India”. Muscle and Nerve 57 (2018): 761‐765.
  10. Kumar M., et al. “Guillain-barré syndrome: a clinical study of twenty children”. Journal of Clinical and Diagnostic Research 9 (2015): SC09‐SC12.
  11. Kannan MA., et al. “Clinical, electrophysiological subtypes and antiganglioside antibodies in childhood Guillain-Barré syndrome”. Neurology India 59 (2011): 727‐732.
  12. Kalra V., et al. “Outcome in childhood Guillain-Barré syndrome”. Indian Journal of Pediatrics 76 (2009): 795‐799.
  13. Asbury AK and Cornblath DR. “Assessment of current diagnostic criteria for Guillain-Barré syndrome”. Annals of Neurology 27 (1990): S21‐S24.
  14. Hadden RD., et al. “Electrophysiological classification of Guillain-Barré syndrome: Clinical associations and outcome. Plasma Exchange/Sandoglobulin Guillain-Barré Syndrome Trial Group”. Annals of Neurology (1998): 780-788.
  15. Hughes RA., et al. “Controlled trial prednisolone in acute polyneuropathy”. Lancet 2 (1987): 750-753.
  16. Korinthenberg R., et al. “Clinical presentation and course of childhood Guillain-Barré syndrome: a prospective multicentre study”. Neuropediatrics 1 (2007): 10-17.
  17. Konuşkan B., et al. “Electrophysiological Subtypes and Prognostic Factors of Childhood Guillain-Barré Syndrome”. Archives of Neuropsychiatry 55 (2018): 199-204.
  18. Sankhyan N., et al. “Childhood Guillain-Barré syndrome subtypes in northern India”. Journal of Clinical Neuroscience 21 (2014): 427‐430.
  19. Yuki N and Hartung HP. “Guillain-Barré syndrome”. The New England Journal of Medicine 366 (2012): 2294-2304.
  20. Sarkar UK., et al. “Spectrum of Guillain-Barré syndrome in tertiary care hospital at Kolkata”. Journal of Natural Science, Biology and Medicine 2 (2011): 211-215.
  21. Nachamkin I., et al. “Patterns of Guillain-Barre syndrome in children: results from a Mexican population”. Published Correction Appears in Neurology 72 (2009): 1110.
  22. Barzegar M., et al. “Predictive factors for achieving independent walking in children with Guillain-Barre syndrome”. Pediatric Research 82 (2017): 333‐339.
  23. Chareyre J., et al. “Acute axonal neuropathy subtype of Guillain Barré syndrome in a French pediatric series: Adequate follow-up may require repetitive electrophysiological studies”. European Journal of Paediatric Neurology 21 (2017): 891-897.
  24. Varkal MA., et al. “Pediatric Guillain-Barré syndrome: Indicators for a severe course”. Annals of Indian Academy of Neurology 18 (2015): 24-28.

Citation

Citation: Rajniti Prasad., et al. “Profile of Children with Guillain Barre Syndrome from tertiary Centre in Eastern Uttar Pradesh: a Prospective Observational Study". Acta Scientific Neurology 5.5 (2022): 66-74.

Copyright

Copyright: © 2022 Rajniti Prasad., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




Metrics

Acceptance rate32%
Acceptance to publication20-30 days

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is December 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"

Contact US