Should We OPT to Induce “Dopamine Homeostasis” in the Long-Term Instead of Prescribing Powerful Opioids (Buprenorphine-Naloxone) to Treat Alcohol and Opioid use Disorders in the Face of the Drug Abuse Epidemic?
Kenneth Blum1,2*, Mark S Gold3, Catherine Dennen2, Eric R. Braverman2, David Baron1, Panayotis K Thanos4,5 and Rajendra D Badgaiyan6
1Division of Addiction Research and Education, Center for Psychiatry, Medicine, and Primary Care (office of Provost), Western University Health Sciences, Pomona, CA, USA
2The Kenneth Blum Behavioral and Neurogenetic Institute, LLC, Austin, TX, USA
3Department of Psychiatry, Washington University School of Medicine, St. Louis, MO., USA
4Behavioral Neuropharmacology and Neuroimaging Laboratory on Addictions, Clinical Research Institute on Addictions, Department of Pharmacology and Toxicology, Jacobs School of Medicine and Biosciences, State University of New York at Buffalo, Buffalo, NY, USA
5Department of Psychology, State University of New York at Buffalo, Buffalo, NY, USA
6Department of Psychiatry, South Texas Veteran Health Care System, Audie L. Murphy Memorial VA Hospital, Long School of Medicine, University of Texas Medical Center, San Antonio, TX, USA
*Corresponding Author: Kenneth Blum, Division of Addiction Research and Education, Center for Psychiatry, Medicine, and Primary Care (office of Provost), Western University Health Sciences, Pomona, CA, USA and The Kenneth Blum Behavioral and Neurogenetic Institute, LLC, Austin, TX, USA.
April 08, 2022; Published:
Addiction clinicians and scientists face an enormous challenge in fighting the global opioid and alcohol use disorder (OUD/AUD) pandemics. Despite significant advances, the number of deaths attributed to narcotic overdose in the United States (US) alone exceeded 100,000 in 2021. The National Institute on Drug Abuse (NIDA) and The National Institute on Alcohol Abuse and Alcoholism (NIAAA) are struggling to generate novel approaches to tackle the severity of the present substance abuse epidemic.
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