Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Review Article Volume 5 Issue 2

Covid-19 Pandemic and Metabolic Aging

Pinky Kain*

Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, India

*Corresponding Author: Pinky Kain, Regional Centre for Biotechnology, NCR Biotech Science Cluster, Faridabad, Haryana, India.

Received: November 26, 2021; Published: January 14, 2022


In contrast to chronological aging, biological aging or metabolic aging is a relative age of cells and tissues and the damage they’ve accumulated over years. Comparison of one’s basal metabolic rate (BMR) to the average BMR of one’s chronological age group gives the Metabolic age. Higher metabolic age of younger population is a serious concern and a key factor that leads to metabolic disorders in all age groups. Slower metabolism is a symbol of older age. Higher metabolic age indicates poor metabolism and higher risk of getting diseases and health complications later in life. Therefore, aging faster metabolically can severely impact chronological age. People with obesity and diabetes suffered the most due to current ongoing Covid-19 pandemic. Data suggest that SARS-CoV-2 patients with concomitant metabolic diseases had higher risk of worse prognosis and mortality. Lowering metabolic age can thus reduce the risk of getting age related health conditions and mitigate morbidities caused by pandemic like Covid-19. Therefore, maintaining healthy metabolic age in all age groups is required in the current unprecedented times. The aim of the review is to raise the prime concerns and to improve the population health outcomes by reducing the metabolic age.

Keywords: Covid-19; Metabolic Aging; Chronological Aging; Obesity; Diabetes


  1. Brazilai N., et al. “The critical role of metabolic pathways in aging”. Diabetes6 (2012): 1315-1322.
  2. Simonnet A., et al. “High Prevalence of Obesity in Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) Requiring Invasive Mechanical Ventilation”. Obesity (Silver Spring) 7 (2020): 1195-1199.
  3. Caussy C., et al. “Prevalence of obesity among adult inpatients with COVID-19 in France”. Lancet Diabetes Endocrinology 8 (2020): 562-564.
  4. Guan WJ and Zhong NS. “Clinical characteristics of covid-19 in China. Reply”. The New England Journal of Medicine 382 (2020): 1861-1862.
  5. Onder G., et al. “Case-fatality rate and characteristics of patients dying in relation to COVID-19 in Italy”. JAMA18 (2020): 1775-1776.
  6. Yang X., et al. “Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study”. Lancet Respiratory Medicine5 (2020): 475-481.
  7. Nigro E., et al. “Molecular mechanisms involved in the positive effects of physical activity on coping with COVID-19”. European Journal of Applied Physiology12 (2020): 2569-2582.
  8. Grippo F., et al. “The role of COVID-19 in the death of SARS-CoV-2-positive patients: a study based on death certificates”. Journal of Clinical Medicine11 (2020): E3459.
  9. Rubino F., et al. “New-onset diabetes in Covid-19”. The New England Journal of Medicine 383 (2020): 789-790.
  10. Pons S., et al. “The vascular endothelium: the cornerstone of organ dysfunction in severe SARS-CoV-2 infection”. Critical Care 24 (2020): 353.
  11. Guan WJ., et al. “Comorbidity and its impact on 1590 patients with covid-19 in China: a nationwide analysis”. European Respiratory Journal5 (2020).
  12. Columbus C., et al. “2019 novel coronavirus: an emerging global threat”. Baylor University Medical Center Proceedings2 (2020): 209-212.
  13. Li B., et al. “Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China”. Clinical Research in Cardiology5 (2020): 531-538.
  14. Nigro E., et al. “Metabolic Perturbations and Severe COVID-19 Disease: Implication of Molecular Pathways”. International Journal of Endocrinology (2020).
  15. Lighter J., et al. “Obesity in patients younger than 60 years is a risk factor for Covid-19 hospital admission”. Clinical Infectious Diseases15 (2020): 896.
  16. Remuzzi A and Remuzzi G. “COVID-19 and Italy: what next?” Lancet (London, England)10231 (2020): 1225-1228.
  17. Peng YD., et al. “Clinical characteristics and outcomes of 112 cardiovascular disease patients infected by 2019-nCoV”. Chinese Journal of Cardiovascular Diseases 48 (2020): 450-455.
  18. Dietz W and Santos-Burgoa C. “Obesity and its Implications for Covid-19 Mortality”. Obesity (Silver Spring)6 (2020): 1005.


Citation: Pinky Kain. “Covid-19 Pandemic and Metabolic Aging". Acta Scientific Neurology 5.2 (2022): 30-33.


Copyright: © 2022 Pinky Kain. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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