Acta Scientific Neurology

Case Report Volume 5 Issue 8

Brief Exercise as a Diagnostic Aid in a Case of Lambert Eaton Myasthenic Syndrome

Anand Karnam, Sai Sirisha, Anuja Patil*, Praveen Kumar Yada, Subhash Kaul

Department of Neurology, Krishna institution of Medical Science, Secunderabad, India

*Corresponding Author: Anuja Patil, Department of Neurology, Krishna institution of Medical Science, Secunderabad, India.

Received: July 12, 2022; Published: July 29, 2022


Background: Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease, affecting the presynaptic neuronal transmission.

Objectives: To represent a case evaluated and confirmed of Lambert Eaton Myasthenic Syndrome.

Methods: 35year old lady with proximal muscle weakness was evaluated with detailed NCS and RNS.

Results: Routine RNS showed decremental response, NCS showed very low CMAPs with marked potentiation post short exercise. Thus incremental response in a patient with pure motor, proximal weakness, areflexia confirmed the diagnosis of LEMS. Her paraneoplastic workup was negative.

Discussion: Non-paraneoplastic LEMS may present with lower limb predominant proximal weakness with subtle autonomic symptoms especially in young females. Bedside clinical examination for pupillary reflexes and postexercise potentiation of tendon reflexes along with increment in CMAP amplitudes aids in confirmation of the diagnosis.


Keywords: LEMS; Potentiation; Non-Paraneoplastic; Presynaptic Neuromuscular Disorders; RNS


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Citation: Anuja Patil., et al. “Brief Exercise as a Diagnostic Aid in a Case of Lambert Eaton Myasthenic Syndrome". Acta Scientific Neurology 5.8 (2022): .


Copyright: © 2022 Anuja Patil., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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