Acta Scientific Neurology

Case Report Volume 5 Issue 8

Brief Exercise as a Diagnostic Aid in a Case of Lambert Eaton Myasthenic Syndrome

Anand Karnam, Sai Sirisha, Anuja Patil*, Praveen Kumar Yada, Subhash Kaul

Department of Neurology, Krishna institution of Medical Science, Secunderabad, India

*Corresponding Author: Anuja Patil, Department of Neurology, Krishna institution of Medical Science, Secunderabad, India.

Received: July 12, 2022; Published: July 29, 2022

Abstract

Background: Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disease, affecting the presynaptic neuronal transmission.

Objectives: To represent a case evaluated and confirmed of Lambert Eaton Myasthenic Syndrome.

Methods: 35year old lady with proximal muscle weakness was evaluated with detailed NCS and RNS.

Results: Routine RNS showed decremental response, NCS showed very low CMAPs with marked potentiation post short exercise. Thus incremental response in a patient with pure motor, proximal weakness, areflexia confirmed the diagnosis of LEMS. Her paraneoplastic workup was negative.

Discussion: Non-paraneoplastic LEMS may present with lower limb predominant proximal weakness with subtle autonomic symptoms especially in young females. Bedside clinical examination for pupillary reflexes and postexercise potentiation of tendon reflexes along with increment in CMAP amplitudes aids in confirmation of the diagnosis.

 

Keywords: LEMS; Potentiation; Non-Paraneoplastic; Presynaptic Neuromuscular Disorders; RNS

References

  1. Seneviratne U and de Silva R. “Lambert-Eaton myasthenic syndrome”. Postgraduate Medical Journal75 (1995): 516-520.
  2. Titulaer MJ., et al. “Lambert-Eaton myasthenic syndrome: from clinical characteristics to therapeutic strategies”. The Lancet Neurology 12 (2011): 1098-1107.
  3. O'Neill JH., et al. “The Lambert-Eaton my, asthenic syndrome. A review of 50 cases”. Brain 111 (1988): 577-596.
  4. Wirtz PW., et al. “Differences in clinical features between the Lambert-Eaton myasthenic syndrome with and without cancer: an analysis of 227 published cases”. Clinical Neurology and Neurosurgery 104 (2002): 359-363.
  5. Odabasi Z., et al. “Postexercise facilitation of reflexes is not common in Lambert-Eaton myasthenic syndrome”. Neurology7 (2002): 1085-1087.

Citation

Citation: Anuja Patil., et al. “Brief Exercise as a Diagnostic Aid in a Case of Lambert Eaton Myasthenic Syndrome". Acta Scientific Neurology 5.8 (2022): .

Copyright

Copyright: © 2022 Anuja Patil., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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