Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Case Report Volume 4 Issue 12

Familial Amyloid Polyneuropathy - A Family Case

Fan Yang1,2, Tan Juan1,2, Wang Xiao-Ming1,2 and Zhang Xiao-Dong2*

1Department of Neurology, The Affiliated Hospital of North Sichuan Medical, Sichuan, China
2Institute of Neurology, North Sichuan Medical College, Sichuan, China

*Corresponding Author: Zhang Xiao-Dong, Institute of Neurology, North Sichuan Medical College, Sichuan, China.

Received: October 28, 2021; Published: November 30, 2021

Abstract

Familial Amyloid Polyneuropathy (FAP) is a relatively rare hereditary amyloidosis, which is an autosomal dominant genetic disease. It is a progressively worsening neurological disease with sensory, motor and autonomic neuropathy as the main manifestations. Patients often have obvious autonomic nervous function, heart, and eye involvement. It is rarer that the disease is manifested by pure peripheral nerve damage. This article reports a case of FAP with pure peripheral nerve damage to the family, in order to improve the neurologist's understanding of the disease.

Keywords: Familial Amyloid Polyneuropathy; Electroneuromyogram; Peripheral Neuropathy; Transthyretin Gene

References

  1. V Planté-Bordeneuve and Said G. “Familial amyloid polyneuropathy”. The Lancet Neurology12 (2011): 1086-1097.
  2. Adams D., et al. “European consensus for diagnosis, management, and treatment of transthyretinfamilial amyloid polyneuropathy”. Current Opinion in Neurology1 (2016): S14-26.
  3. Sekijima Y., et al. “Diagnosis and management of transthyretin familial amyloid polyneuropathy in Japan: red-flag symptom clusters and treatment algorithm”. Orphanet Journal of Rare Diseases1 (2018): 6.
  4. Liu YT., et al. “Transthyretin Ala97Ser in Chinese–Taiwanese patients with familial amyloid polyneuropathy: Genetic studies and phenotype expression”. Journal of the Neurological Sciences 1-2 (2008): 91-99.
  5. Yang CC., et al. “Clinical presentations and skin denervation in amyloid neuropathy due to transthyretin Ala97Ser”. Neurology6 (2010): 532-538.

Citation

Citation: Zhang Xiao-Dong., et al. “Familial Amyloid Polyneuropathy - A Family Case”. Acta Scientific Neurology 4.12 (2021): 66-69.

Copyright

Copyright: © 2021 Zhang Xiao-Dong., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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