Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Research Article Volume 4 Issue 10

Neural Tube Malformations: Monocentric Results of Operated Cases

Rasolonjatovo EC1*, Rakotovao TK1, Tsiaremby MG1, Ramarokoto M1, Ratovondrainy W2, Rabarijaona M3 and Adriamamaomonjy C1

1Neurosurgery Department, Joseph Andrianavalona University Hospital Center (CHU-HJRA), Antananarivo, Madagascar
2Neurosurgery Department, Soavinadriana Hospital Center (CENHOSOA),Antananarivo, Madagascar
3Department of Neurosurgery, University Hospital Center (CHU) Tambohobe, Fianarantsoa, Madagascar

*Corresponding Author: Rasolonjatovo EC, Neurosurgery Department, Joseph Andrianavalona University Hospital Center (CHU-HJRA), Antananarivo, Madagascar.

Received: August 23, 2021; Published: September 23, 2021


Introduction: NTDs are malformations of the central nervous system. It’s therapeutic complexities and the functional future of the child are the challenges in their management. The main objective of this study is to identify the epidemiological profile and short-term prognosis of these abnormalities.

Methods: This is a retrospective, descriptive study over a period of four years.

Results: The frequency of NTDs was of the order of 10 cases/year. The male gender was the most affected with a sex ratio of 2. The most common anatomoclinical form was Meningocele (53.65%). The association with congenital hydrocephalus found in this study was 26.82%. Nearly thirty-four percent of cases were children born of younger mothers, and the prenatal consultation rate was effective for 51.21%. Maternal infection was found in 58.53%. Folic acid intake during pregnancy was found in 82.73%. Surgery repair of the deformity was generally successful. Meningitis was the main complication. There were 4.87% of deaths related to serious cardiopulmonary diseases.

Conclusion: A clear male predominance of this condition, a significant history of maternal infection, the majority of anterior meningocele type topography, specify our series. Surgical outcomes are generally good except for a few manageable infected cases. The periconceptional and prenatal regular consultations are to be sensitized in order to prevent and reduce these abnormalities.

Keywords: Folic Acid; Prenatal Ultrasonography; Surgery; Tube Neural Defects


  1. Copp AJ., et al. “Neural tube defects--disorders of neurulation and related embryonic processes”. Wiley Interdisciplinary Reviews: Developmental Biology2 (2013) :213-227.
  2. Botto LD., et al. “Neural-tube defects”. The New England Journal of Medicine 20 (1999): 1509-1519.
  3. Sanoussi S., et al. “Malformations du tube neural au Niger : à propos de 387 cas en 10 ans ; Plaidoyer pour un traitement préventif par l’acide folique en période Périconceptionelle”. Medecine d'Afrique noire 12 (2001): 510-515.
  4. Ouattara O., et al. “Les myélomeningocèles en Afrique : cas de la Cote d’ivoire”. Medecine d'Afrique 7 (1997): 402 404.
  5. Macé G., et al. “Anomalies neurologiques fœtales. Diagnostic prénatal échographique”. EMC Gynécologie/obstétrique7 (2007): 5-031-A-33.
  6. Van Allen M., et al. “Recommendations on the use of folic acid supplementation to prevent the recurrence of neural tube defects”. Clinical Teratology Committee, Canadian College of Medical Geneticists 9 (1993): 1239-1243.
  7. Alatise OI., et al. “Pattern and factors affecting management outcome of spina bifida cystica in Ile-Ife, Nigeria”. Pediatric Neurosurgery5 (2006): 277-283.
  8. Copp AJ., et al. “Genetics and development of neural tube defects”. Journal of Pathology2 (2010): 217-230.
  9. Lorber J. “The Family History Of Spina Bifida Cystica”. Pediatrics 35 (1965): 589-595.
  10. Van Allen MI., et al. “Evidence for multi-site closure of the neural tube in humans”. American Journal of Medical Genetics (1993): 723-743.
  11. Dahl M., et al. “Utilization of medical care among children with spina bifida”. Fluids Barriers CNS 2 (2005): S55.
  12. Ingalls Th., et al. “Congenital Malformations. Clinical and Community considerations”. The American Journal of the Medical Sciences 249 (1965): 316-344.
  13. Kit SA., et al. “Epidemiologic and genetic aspects of Spina bifida and other neural tube Defects”. Developmental Disabilities Research Reviews 1 (2010): 6-15.
  14. Vieira AR., et al. “Maternal age and neural tube defects: evidence for a greater effect in spina bifida than in anencephaly”. Revista Médica de Chile 1 (2005): 62-70.
  15. Cameron M., et al. “Prenatal screening and diagnosis of neural tube defects”. Prenatal Diagnosis 29 (2009): 402-411.
  16. Cavalli P., et al. “Inositol supplementation in pregnancies at risk of apparently folate-resistant NTDs”. Birth Defects Research Part A: Clinical and Molecular Teratology 7 (2008): 540-542.
  17. Brough L., et al. “Social and ethnic differences in folic acid use preconception and during early pregnancy in the UK: effect on maternal folate status”. Journal of Human Nutrition and Dietetics 2 (2009): 100-107.
  18. Kumar Nordique R., et al. “Spinal dysraphism: trends in northern India”. Pediatric Neurosurgery3 (2003): 133-145.
  19. Boyles AL., et al. “Neural Tube Defects and Folates Pathway Genes: Family-based association; tests of gene–gene and gene–environment interactions”. Environmental Health Perspectives Journal10 (2006): 1547-1552.
  20. Nataf F., et al. “Spina Bifida”. Université francophone. Aupelf Uref. Edition. Marketing. Eclipse 58 (1995): 577-578.
  21. Copp AJ., et al. “The embryonic development of mammalian neural tube defects”. Progress in Neurobiology 5 (1990): 363-403.


Citation: Rasolonjatovo EC., et al. “Neural Tube Malformations: Monocentric Results of Operated Cases”. Acta Scientific Neurology 4.10 (2021): 38-44.


Copyright: © 2021 Rasolonjatovo EC., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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