Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Case Report Volume 4 Issue 12

Headache and MTHFRT677T Genotype in a Young Woman - Clinical Case

Damelan Kombate1*, Sirui Zhou2, Seylom Kossi Biosse3, Agbémélé K M Soedje3, Kossivi Apetse3, Komi Assogba3, Koffi AA Balogou3 and Guy A Rouleau2

1Department of Neurology, University of Kara, Togo
2Teaching Hospital Campus, Neurology Department, University of Lomé, Togo
3Montreal Neurological Institute and Hospital, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada

*Corresponding Author: Damelan Kombate, Department of Neurology, University of Kara, Togo.

Received: June 20, 2021; Published: November 12, 2021

Abstract

Introduction: The MTHFRC677T polymorphism is involved in several pathologies.

Objectives: We report one case of headache associated with the MTHFR T677T genotype in a woman.

Observation: A 39-year-old woman was admitted in neurology department on March 12, 2012 for headaches with feet and hands parathesia for several months. The physical examination had noted a decrease in osteotendinous reflexes and an abolition of the plantar cutaneous reflex. Hamilton’s 17-item depression score was 7. In the etiological investigation of probable polyneuropathy, homocysteine was 88.39 μmol/l (standard < 15 μmol/l), folates 2.34 nmol/l (standard ≥ 11 nmol/l) and vitamin B12 132 pmol/l (standard ≥ 147 pmol/l). The aetiological investigation of this hyperhomocysteinemia revealed an MTHFRT677T genotype.

Conclusion: The MTHFRT677T genotype is associated with a variety of manifestations ranging from metabolic (B12 deficiency), headache and polyneuropathies.

Keywords: MTHFR Polymorphism; Headache; Polyneuropathy

References

  1. Haruki Koike., et al. “Clinicopathologic features of folate-deficiency neuropathy”. Neurology10 (2015): 1026-1033.
  2. Sechi GP., et al. “Clinicopathologic features of folate-deficiency neuropathy”. Neurology 12 (2015): 1090-1091.
  3. Bech P. “Fifty years with the Hamilton scales for anxiety and depression. A tribute to Max Hamilton”. Psychotherapy and Psychosomatics 4 (2009): 202-211.
  4. Kobayashi Y., et al. “Severe leukoencephalopathy with cortical involvement and peripheral neuropathy due to FOLR1 deficiency”. Brain Development3 (2017): 266-270.
  5. Bruce SG and Young TK. “Prevalence and risk factors for neuropathy in a Canadian First Nation community”. Diabetes Care 31 (2008): 1837-1841.
  6. Ambrosch A., et al. “Relation between homocysteinaemia and diabetic neuropathy in patients with Type 2 diabetes mellitus”. Diabetic Medicine 18 (2001): 185-192.
  7. Cohen JA., et al. “Increasing homocysteine levels and diabetic autonomic neuropathy”. Autonomic Neuroscience 87 (2001): 268-273.
  8. González R., et al. “Plasma homocysteine levels are independently associated with the severity of peripheral polyneuropathy in type 2 diabetic subjects”. Journal of the Peripheral Nervous System 17 (2012): 191-196.
  9. Jianbo L., et al. “Association of homocysteine with peripheral neuropathy in Chinese patients with type 2 diabetes”. Diabetes Research and Clinical Practice 93 (2011): 38-42.
  10. Luo JJ., et al. “Elevated plasma level of homocysteine is an independent risk factor for peripheral neuropathy”. British Journal of Medicine and Medical Research 4 (2014): 161-169.
  11. Herrmann W., et al. “Review of the role of hyperhomocysteinemia and B-vitamin deficiency in neurological and psychiatric disorders--current evidence and preliminary recommendations”. Fortschritte der Neurologie · Psychiatrie 75 (2007): 515-527.
  12. Ansari R., et al. “Hyperhomocysteinemia and Neurologic Disorders: a Review”. Journal of Clinical Neurology 10 (2014): 281-288.
  13. Tozzi E., et al. “The Headaches and Polymorphisms of the Methylenetetrahydrofolate Reductase”. Journal of Headache and Pain Management 2 (2017): 12.

Citation

Citation: Damelan Kombate., et al. “Headache and MTHFRT677T Genotype in a Young Woman - Clinical Case”. Acta Scientific Neurology 4.12 (2021): 37-40.

Copyright

Copyright: © 2021 Damelan Kombate., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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