Damelan Kombate¹*, Sirui Zhou², Seylom Kossi Biosse³, Agbémélé K M Soedje³, Kossivi Apetse³, Komi Assogba³, Koffi AA Balogou³ and Guy A Rouleau²

¹Department of Neurology, University of Kara, Togo
²Teaching Hospital Campus, Neurology Department, University of Lomé, Togo
³Montreal Neurological Institute and Hospital, Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada

*Corresponding Author: Damelan Kombate, Department of Neurology, University of Kara, Togo.

Received: June 20, 2021; Published: November 12, 2021

Abstract

Introduction: The MTHFRC677T polymorphism is involved in several pathologies.

Objectives: We report one case of headache associated with the MTHFR T677T genotype in a woman.

Observation: A 39-year-old woman was admitted in neurology department on March 12, 2012 for headaches with feet and hands parathesia for several months. The physical examination had noted a decrease in osteotendinous reflexes and an abolition of the plantar cutaneous reflex. Hamilton’s 17-item depression score was 7. In the etiological investigation of probable polyneuropathy, homocysteine was 88.39 μmol/l (standard < 15 μmol/l), folates 2.34 nmol/l (standard ≥ 11 nmol/l) and vitamin B₁₂ 132 pmol/l (standard ≥ 147 pmol/l). The aetiological investigation of this hyperhomocysteinemia revealed an MTHFRT677T genotype.

Conclusion: The MTHFRT677T genotype is associated with a variety of manifestations ranging from metabolic (B₁₂ deficiency), headache and polyneuropathies.

Keywords: MTHFR Polymorphism; Headache; Polyneuropathy

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Citation

Citation: Damelan Kombate., et al. “Headache and MTHFRT677T Genotype in a Young Woman - Clinical Case”. Acta Scientific Neurology 4.12 (2021): 37-40.

Copyright

Copyright: © 2021 Damelan Kombate., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.