Outcome of Adult and Pediatric Posterior Fossa Tumors Linked with Histopathological subtypes - Observations of Two Decades
Abdul Rashid Bhat1*, Muhammed Afzal Wani2 and Altaf Rehman Kirmani1
1Professor, Department of Neurosurgery, SKIMS Srinagar, Kashmir, India
2Professor and Head, Department of Neurosurgery, SKIMS Srinagar, Kashmir, India
*Corresponding Author: Abdul Rashid Bhat, Professor and Unit Head, Department of Neurosurgery, SKIMS Srinagar, Kashmir, India.
March 19, 2021; Published: August 07, 2021
Objectives: To analyze the link between histopathological-type of posterior fossa tumors (PFTs) and the outcome in children and adults. The postoperative quality and span-of-life in these tumors is complicated by the residual disease, progression, recurrence, disabilities and mortality.
Materials and Methods: The histopathological records of 410 PFTs out of 589 patients were compared with their clinical outcome up to first postoperative-year in a single-centre, amounting to regional epidemiological-value. In this observational study, retrospectively postoperative records of 589 PFTs from November 1990 to December 2010 (20 years) were retrieved, scrutinized and compiled. The post-operative records of 410 patients with proved histopathological-examination results were included. The statistical law of Variance was applied where-ever necessary.
Results: The 63.2% of 410 operated PFTs were males while females predominated in meningiomas and pineoblastomas. About 31.7% PFTs were children (below-18yrs.). About 54.1% cases were histologically malignant. The residual-tumors comprised 40.2% and symptoms of disease-progression occurred in 10.9%. The tumor recurrence occurred in 14.3% while 6.0% patients developed severe-disability. The overall mortality was 11.4% up to first post-operative year with 18.9% in malignant patients. The first-one-year event free survival (EFS) for all the patients was 66.0%. While the patients with malignancies had first-one-year EFS of 47.7%, the histologically benign group had 87.7%.
Conclusion: The first one-year postoperative EFS of histologically benign and some malignant PFTs both in children and adults like pilocytic astrocytomas, ependymomas and pineoblastomas was much better (87.7%) than other malignant PFTs.
Keywords: Outcome; Posterior Fossa Tumours; Histopathological Subtypes; Children-adults
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