Pushpanjali R Ojha¹*, Mohd Saif Khan², Pradip Kumar Bhattacharya³, Aneesha Thomas⁴ and Kritika Raj⁵

¹Assistant Professor (Pathology), Trauma Center, RIMS, Ranchi, Jharkhand, India
²Associate Professor, Department of Critical Care Medicine, RIMS, Jharkhand, India
³Professor and HOD, Department of Critical Care Medicine, Trauma Center, RIMS, Jharkhand, India
⁴Assistant Professor, Department of Neurology, RIMS, Ranchi, India
⁵Junior Resident, Department of Anaesthesia, RIMS, Ranchi, India

*Corresponding Author: Pushpanjali R Ojha, Assistant Professor (Pathology), Trauma Center, RIMS, Ranchi, Jharkhand, India.

Received: July 08, 2021; Published: July 28, 2021

Abstract

Background: The neurotropic effect of SARS - CoV2 virus manifests as inflammatory and demyelinating changes. The major entities reported were stroke, GBS, ADEM and encephalitis. A rare case of sensory motor polyneuropathy (SMPN) in COVID 19 was reported in our institute.

Methods: A COVID19 diseased patient without any previous neurological disorders was admitted and during the course of treatment developed neurological complications. After complete radiological and pathological evaluation he was diagnosed as a case of SMPN - a new manifestation of SARS - CoV2 infection.

Results: HRCT chest shows COVID 19 related ARDS, MRI (T2W) at D6-10 spines shows subtle patchy intramedullary high signal intensity and Nerve conduction study revealed asymmetrical sensory-motor polyneuropathy. He had leucocytosis with neutrophilia, lymphopenia, raised Neutrophil-lymphocyte ratio, D-Dimer and ferritin.

Conclusion: SMPN is relatively rare but acute manifestation of SARS-CoV2 infection which need immediate management and long term follow up to diagnose chronic complication related with it.

Keywords: Guillain - Barre Syndrome; Sensory Motor Polyneuropathy; Nerve Conduction Study

References

1. Mao L., et al. “Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China”. JAMA Neurology6 (2020): 683-690.
2. Desforges M., et al. “Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system?” Viruses 1 (2019): 14.
3. Baig AM., et al. “Evidence of the COVID-19 virus targeting the CNS: tissue distribution, host-virus interaction, and proposed neurotropic mechanisms”. ACS Chemical Neuroscience 7 (2020): 995-998.
4. Wrapp D., et al. “Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation”. Science 6483 (2020): 1260-1263.
5. Mehta P., et al. “COVID-19: consider cytokine storm syndromes and immunosuppression”. Lancet 10229 (2020): 1033-1034.
6. Zhao H., et al. “Guillain-Barrè syndrome associated with SARS-CoV-2 infection: causality or coincidence?” Lancet Neurology5 (2020): 383-384.
7. Zhang T., et al. “COVID-19-associated acute disseminated encephalomyelitis: a case report”. MedRxiv (2020).
8. Zanin L., et al. “SARS-CoV-2 can induce brain and spine demyelinating lesions”. Acta Neurochirurgica (2020).
9. Solomon T and Willison H. “Infectious causes of acute flaccid paralysis”. Current Opinion in Infectious Diseases 16 (2003): 375-381.

Citation

Citation: Pushpanjali R Ojha., et al. “Sensory Motor Polyneuropathy in a COVID 19 Patient: An Interesting Case Report”. Acta Scientific Neurology 4.8 (2021): 68-71.

Copyright

Copyright: © 2021 Pushpanjali R Ojha., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.