Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Research Article Volume 4 Issue 8

Comparison of Hyperbaric and Isobaric Solution of Bupivacaine in Spinal Anaesthesia

Arun R* and Girish Kumar J

Sree Uthradom Thirunal Academy of Medical Sciences (SUTAMS), Thiruvananthapuram, Kerala, India

*Corresponding Author: Arun R, Assistant Professor, Department of Anaesthesiology, Sree Uthradom Thirunal Academy of Medical Sciences (SUTAMS), Thiruvananthapuram, Kerala, India.

Received: June 11, 2021; Published: July 28, 2021

Abstract

Aims: The primary objective of the study was to compare the efficacy of administration of isobaric versus hyperbaric bupivacaine for spinal anaesthesia in patients undergoing lower abdominal and lower limb surgeries. Administering hyperbaric solution intrathecally is advisable for lower abdominal surgeries as the drug was found to produce a high sensory block when compared with isobaric bupivacaine. The longer duration of analgesia and the more gradual fall in blood pressure seen with isobaric bupivacaine are definite advantages over hyperbaric preparations. The isobaric preparation is of much help in perineal and lower limb surgeries.

Objectives: We tried to compare the efficacy of both hyperbaric and isobaric preparations of bupivacaine and if possible to replace hyperbaric with isobaric solution.

Methods: 80 patients in the age group 20-60 years undergoing elective surgery and belonging to ASA grade I& II were studied. These patients were divided into 2 equal groups of 40 each-Group I as those who received hyperbaric bupivacaine and group II as those who received isobaric bupivacaine. In the case of qualitative data, percentage were calculated and the association between the variables was tested statistically with the help of Chi-square test. The equality of the mean values of the two groups was tested by applying Student’s t test.

Results: There was no statistical difference in outcome between the two groups in age, height, weight and sex. The mean number of segments blocked in the two groups appeared small, but it was statistically highly significant (P < 0.001). The isobaric group took 11.8 minutes as the time of latency of maximal spread compared to only 10.78 minutes in hyperbaric group (P < 0.01). While considering the duration of motor block, isobaric group necessitated 248.75 minutes whereas it was only 211.63 minutes in the hyperbaric group (P < 0.001). The duration of analgesia also was found to be greater with the isobaric group (P < 0.001).

Conclusion: The anaesthetic properties of isobaric and hyperbaric bupivacaine were compared after intrathecal injection undergoing lower abdominal, perineal and lower limb surgeries. Hyperbaric bupivacaine administered produced the highest spread of analgesia, up to T7. Isobaric solution resulted in spread of analgesia to T9 only. While motor block in the legs were good in both the cases, the onset was faster with the hyperbaric group. The longest duration of analgesia recorded was found to be greater with the isobaric group. The course of anaesthesia and recovery were uneventful in all patients of both the groups.

Keywords: Spinal Anaesthesia; Bupivacaine; Isobaric; Hyperbaric; Intrathecal

References

  1. Alston RP. “Spinal anesthesia with 0.5% bupivacaine 3 ml comparison of plain and hyperbaric solution administered to seated patients”. British Journal of Anaesthesia 4 (1988): 385-389.
  2. Becker J., et al. “Density of cerebrospinal fluid and local anesthetics”. Anaesthesist 10 (1979): 81-83.
  3. Blomquist H and Nilsson A. “Is glucose free bupivacaine isobaric or hypobaric”. Regional Anesthesia 4 (1989): 195-198.
  4. Butterworth J F and Strichartz G. “Molecular mechanism of local anaesthesia: a review”. Anaesthesiology 72 (1990): 711-716.
  5. Camaron AE., et al. “Spinal analgesia using bupivacaine 0.5% plain variation in the extend of block with patient age”. Anesthesia 36 (1981): 318-322.
  6. Carpenter RL., et al. “Incidence and risk factors for side effects of spinal anaesthesia”. Anaesthesiology 76 (1992): 906-909.
  7. Chambers WA., et al. “Effect of baricity on spinal anesthesia with bupivacaine”. British Journal of Anaesthesia 3 (1981): 279-282.
  8. Dohi S., et al. “Age related changes in blood pressure and duration of motor block in spinal anesthesia”. Anesthesiology 50 (1979): 319-321.
  9. Gleizal B. “Effect of increasing amounts of epinephrine during isobaric & hyperbaric bupivacaine spinal anesthesia in elderly patients”. Anesthesia and Analgesia 9 (1987): 882-886.
  10. Greene N M. “Uptake and elimination of local anesthetics during spinal anesthesia”. Anesthesia and Analogy 62 (1983): 1013-1015.
  11. Hirabayashi Y., et al. “Spread of spinal anaesthesia with 0.5% isobaric and hyperbaric bupivacaine”. Masui 42 (1993): 1628-1634.
  12. Kalso E., et al. “The effect of posture and some CSF characteristics on spinal anaesthesia with isobaric bupivacaine 0.5%”. British Journal of Anaesthesia 11 (1982): 1179-1184.
  13. Kruger D., et al. “Effect of glucose concentration on spinal anesthesia with bupivacaine 0.5%”. Regional Anesthesia 1 (1983): 1-3.
  14. Logan MR., et al. “Plain bupivacaine; An unpredictable spinal anaesthetic agent”. British Journal of Anaesthesia 3 (1986): 292-296.
  15. Mahe V and Ecoffey C. “Spinal anesthesia with isobaric bupivacaine in infants”. Anesthesiology 68 (1988): 601-608.
  16. McMahon D. “Managing regional anesthesia equipment”. Anaesthesia 1 (1987): 592-598.
  17. Moore DC and Bridenbaugh L D. “Spinal (subarachnoid) block: a review of 11,574 cases”. JAMA 195 (1966): 907-909.
  18. Nielsen TH., et al. “Plain bupivacaine 0.5% or 0.25% for spinal analgesia”. British Journal of Anaesthesia 2 (1989): 164-167.
  19. Nolte H., et al. “On spinal anaesthesia with isobaric bupivacaine 0.5%”. Anaesthesist 1 (1977): 33-37.
  20. Nolte H., et al. “The dose effect ratio of isobaric bupivacaine in spinal analysis”. Anaesthesist 1 (1979): 1-4.
  21. Phelan DM and Mac Evilly M. “A comparison of hyper and isobaric solutions of bupivacaine for subarachnoid block”. Anaesthesia - Intensive Care 2 (1984): 101-107.
  22. Pitkanen M., et al. “Effects of aspiration of CSF on spinal anaesthesia with isobaric 0.5% bupivacaine”. Acta Anaesthesiologica Scandinavica 6 (1985): 590-593.
  23. Pitkanen M. “Body mass and spread of anaesthesia with bupivacaine”. Anesthesia and Analgesia 2 (1987): 127-131.
  24. Pitkanen M., et al. “The influence of age of spinal anaesthesia with isobaric& hyperbaric 0.5% bupivacaine”. British Journal of Anaesthesia 56 (1984): 279-284.
  25. Racle JP., et al. “Effect of adding sodium bicarbonate to bupivacaine for spinal anaesthesia in elderly patients”. Anesthesia and Analgesia 6 (1988): 570-573.
  26. Vichitvejpaisal P and Svastdi Xuto O. “0.5 percent plain bupiacaine for spinal anesthesia effect of posture”. Journal of the Medical Association of Thailand 6 (1989): 687-691.

Citation

Citation: Arun R and Girish Kumar J. “Comparison of Hyperbaric and Isobaric Solution of Bupivacaine in Spinal Anaesthesia”. Acta Scientific Neurology 4.8 (2021): 60-67.

Copyright

Copyright: © 2021 Arun R and Girish Kumar J. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.




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