Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Review Article Volume 4 Issue 8

An Update on Neurological Outcome in Covid-19 Crisis: Hypercoagulability

Mathur Mathur1* and Rupjyoti Das1

1Diploma Vascular Med (UK), Clinical Ph.D. Neurology (UK) and Fellow of European Academy of Neurology, Consultant Neurologist, Department of Clinical Neurology, GNRC Hospitals, Guwahati, India
2Head of Department and Senior Consultant, Department of Clinical Neurology, GNRC Hospitals, Guwahati, India

*Corresponding Author: Manik Mathur, Diploma Vascular Med (UK), Clinical Ph.D. Neurology (UK) and Fellow of European Academy of Neurology, Consultant Neurologist, Department of Clinical Neurology, GNRC Hospitals, Guwahati, India

Received: May 26, 2021; Published: June 29, 2021


  Recent pandemic surge of Covid-19 has made it necessary to further understand a detailed neurological association with the virus in-relation to sub-clinical picture. Additionally, in the presence of a sweeping corona virus wave throughout the globe, pre-liminary studies have indicated a strong association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in addition to neuropsychiatric and neurological illness. Following a trivial research (clinical and paraclinical data), five major scenarios have been observed, namely, encephalopathies with no distinct MRI or CSF abnormalities, inflammatory CNS syndrome (including para-or-post-infections) with/out isolated myelitis, ischaemic strokes associated with pro-thrombotic state, peripheral neurological disorders such as Guillain-Barre syndrome and other miscellaneous neurological disorders. Therefore, an early recognition and understanding in the backdrop of neuropathology associated with COVID-19 is essential. Where hypercoagulability is a newfangled conduit in further complicating the pathogenesis to unreasonable levels. Here, a brief discussion on present neurology associated outcomes in COVID-19 scenario.

Keywords: SARS-CoV-2; COVID-19; Peripheral Nervous System (PNS)


  1. Qureshi AI., et al. “Acute Ischemic Stroke and COVID-19: An Analysis of 27 676 Patients”. Stroke 3 (2021): 905-912.
  2. Moriguchi T., et al. “A first case of meningitis/encephalitis associated with SARS-Coronavirus-2”. International Journal of Infectious Diseases 94 (2020): 55-58.
  3. Helms J., et al. “Delirium and encephalopathy in severe COVID-19: a cohort analysis of ICU patients”. Critical Care1 (2020): 491.
  4. Beyrouti R., et al. “Characteristics of ischaemic stroke associated with COVID-19”. Journal of Neurology, Neurosurgery, and Psychiatry 8 (2020): 889-891.
  5. Toscano G., et al. “Guillain-Barre Syndrome Associated with SARS-CoV-2”. The New England Journal of Medicine 26 (2020): 2574-2576.
  6. Franceschi, A.M., et al. “Hemorrhagic Posterior Reversible Encephalopathy Syndrome as a Manifestation of COVID-19 Infection”. AJNR American Journal of Neuroradiology7 (2020): 1173-1176.
  7. Mahammedi, A., et al. “Imaging in Neurological Disease of Hospitalized COVID-19 Patients: An Italian Multicenter Retrospective Observational Study”. Radiology (2020): 201933.
  8. Qu, W., et al. “Cell-based therapy to reduce mortality from COVID-19: Systematic review and meta-analysis of human studies on acute respiratory distress syndrome”. Stem Cells Translational Medicine 9 (2020): 1007-1022.
  9. Manson JJ., et al. “COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study”. Lancet Rheumatology (2020).
  10. Hung EC., et al. “Detection of SARS coronavirus RNA in the cerebrospinal fluid of a patient with severe acute respiratory syndrome”. Clinical Chemistry 12 (2003): 2108-2109.
  11. Xu J., et al. “Detection of severe acute respiratory syndrome coronavirus in the brain: potential role of the chemokine mig in pathogenesis”. Clinical Infectious Diseases 8 (2005): 1089-1096.
  12. Ellul MA., et al. “Neurological associations of COVID-19”. Lancet Neurology9 (2020): 767-783.
  13. Paterson RW., et al. “The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings”. Brain (2020).
  14. Connors JM and JH Levy. “COVID-19 and its implications for thrombosis and anticoagulation”. Blood23 (2020): 2033-2040.
  15. Terpos E., et al. “Hematological findings and complications of COVID-19”. American Journal of Hematology7 (2020): 834-847.
  16. Bikdeli B., et al. “COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-Up: JACC State-of-the-Art Review”. Journal of the American College of Cardiology 23 (2020): 2950-2973.
  17. Prompetchara E., et al. “Immune responses in COVID-19 and potential vaccines: Lessons learned from SARS and MERS epidemic”. Asian Pacific Journal of Allergy and Immunology 1 (2020): 1-9.
  18. Zhou F., et al. “Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study”. Lancet10229 (2020): 1054-1062.


Citation: Mathur Mathur and Rupjyoti Das. “An Update on Neurological Outcome in Covid-19 Crisis: Hypercoagulability”. Acta Scientific Neurology 4.8 (2021): 70-72.


Copyright: © 2021 Mathur Mathur and Rupjyoti Das. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


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