Co-ultraPEALut Effect on Mild Cognitive Impairment: A Retrospective Observational Study
Barbara Manni1*, Lucia Federzoni2, Patrizia Zucchi1 and Andrea Fabbo1
1Cognitive Disorders and Dementia Unit, Primary Care Department, Local Agency for Health (AUSL) of Modena, Italy
2School of Geriatrics, University of Modena and Reggio Emilia, Modena, Italy
*Corresponding Author: Barbara Manni, Cognitive Disorders and Dementia Unit, Primary Care Department, Local Agency for Health (AUSL) of Modena, Italy.
April 15, 2021; Published: June 04, 2021
Mild cognitive disorder (MCI) may precede the onset of cognitive decline. Neuroinflammation may have a leading role in early phase of many neurocognitive diseases and may represent a useful target to limit MCI progression. Palmitoylethanolamide is endowed with anti-inflammatory and neuroprotective activities. Its formulation containing luteolin (PEALut) has been found to improve memory impairments in experimental models and in cognitively impaired patients suggesting its potential use for delaying the dementia onset. This retrospective study provides a preliminary evaluation of PEALut effect on clinical aspects in MCI subjects. Data related to three MCI subject groups, matched case control for age, sex and comorbidity, were obtained via retrospective chart review. Groups received PEALut, dietary food and no treatment, respectively. Mini-Mental State Examination (MMSE) questionnaire was used to evaluate cognitive symptoms; Activity Daily Living and Instrumental Activity functional Daily Living were used for measuring activity daily living and functional status; UCLA-Neuropsychiatric Inventory was used for behavioral symptoms. All evaluations were performed at the baseline and after 6 months. PEALut group showed a significant improvement in short-term memory MMSE domain. Non cognitive behavioral disturbs were also improved in PEALut group. This latter effect seems to be limited to nonamnestic MCI patients. The data reported add another piece of the framework of evidence supporting the ability of PEA, or its composites, to slow down the progression of diseases of the central nervous system, and encourage to perform a double-blind clinical study to deepen PEALut effects on cognitive and non cognitive alterations.
Keywords: Dementia; Mild Cognitive Disorder; Neuropsychiatric Symptoms; PEALut
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