Benign Sacrococcygeal Teratoma in Adults: A Systematic Review of the Literature
Anudeep Yekula1*, Sulekhya Inturu2, Samiksha Jain2, Anuroop Yekula2, Abhinaya Kotha2, Anurag Pasula3 and Kiran Kumar Yekula4
1Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
2Government General Hospital, Guntur Medical College, Guntur, India
3Government General Hospital, Rangaraya Medical College, Kakinada, India
4Kocher's Institute of Medical Sciences, Guntur, India
*Corresponding Author: Anudeep Yekula, Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
April 16, 2021; Published: May 25, 2021
Introduction: Sacrococcygeal teratomas are tumors derived from embryonic germ cell layers predominantly occurring in pediatric cohorts. They are rare in adults and limited data exists on their clinicopathologic characteristics and their management.
Methods: The aim of the study is to explore the demographic, clinical, radiographic, histopathologic, and the management of SCT in adults through a comprehensive systematic review of literature.
Results: A total of 73 patients with benign sacrococcygeal teratoma were identified (51, 69.8% female), with a median age of 30.25 years. Patients mostly presented with pelvic pain (n = 37) and/or palpable mass (n = 33). The majority of the tumors belonged to Altman type IV (28, 56%). Surgical resection with coccygectomy was almost always curative.
Conclusion: Benign SCTs require multidisciplinary management. Careful evaluation is required in all cases of sacral masses, and prompt differentiation of benign entities from the malignant counterparts is central to the management of these lesions.
Keywords: Sacrococcygeal Teratoma; SCT; Adult; Benign
- Kremer M E B., et al. “Quality of life in adulthood after resection of a sacrococcygeal teratoma in childhood: a Dutch multicentre study”. Archives of Disease in Childhood - Fetal and Neonatal Edition 100 (2015): F229-232.
- Luk S Y., et al. “Sacrococcygeal teratoma in adults: case report and literature review”. Hong Kong Medical Journal 17 (2011): 417-420.
- Zhang F., et al. “Mucinous tumor arising in a giant sacrococcygeal teratoma: A rare case report. Medicine 96 (2017): e8759.
- Sheng QS., et al. “Multi-stage resection and repair for the treatment of adult giant sacrococcygeal teratoma: A case report and literature review”. Oncology Letter 10 (2015): 425-429.
- Diaz-Aguilar D., et al. “Adult sacrococcygeal teratoma with coccygectomy: A case report with a review of the literature”. Surgical Neurology International 8 (2017): 260.
- Yekula MSKK and Yekula A. “Adult Sacrococcygeal Teratoma: The third leg: A rare case report in a 25 year old man”. International Journal of Surgery Case Reports 14 (2015): 146-148.
- Babiker T., et al. “Acromegaly and Cushing’s syndrome caused by a neuroendocrine tumor arising within a sacrococcygeal teratoma”. Clinical Case Report 5 (2017): 1768-1771.
- Xu XM., et al. “Adult sacrococcygeal teratoma: a retrospective study over eight years at a single institution”. Journal of Zhejiang University Science B 20 (2019): 670-678.
- Kumar N., et al. “Sacro-coccygeal teratoma in adult: Two rare case reports and review of literature”. International Journal of Applied and Basic Medical Research 4 (2014): 122-124.
- Shatnawi N J., et al. “A giant sacrococcygeal teratoma in adult female: A case report”. International Journal of Surgery Case Reports 54 (2019): 47-50.
- Sukhadiya M V and Das U. “Laparoscopic Approach to Type IV Sacrococcygeal Teratoma in an Adult”. Indian Journal of Surgery 77 (2015): 62-63.
- Afuwape O O., et al. “Adult sacrococcygeal teratoma: a case report”. Ghana Medical Journal 43 (2009): 40-42.
- Szyllo K and Lesnik N. “Sacrococcygeal teratoma - case report and review of the literature”. American Journal of Case Reports 14 (2013): 1-5.
- Mourad A P., et al. “A case of an asymptomatic sacrococcygeal teratoma diagnosed in adulthood”. Surgical Case Reports 2020 (2020): rjaa462.
- Miles R M., et al. “Sacrococcygeal teratomas in adult”. Annals of Surgery 179 (1974): 676-683.
- Ng E W., et al. “Sacrococcygeal teratoma in adults: case reports and a review of the literature”. Cancer 86 (1999): 1198-1202.
- Conklin J and Abell M R. “Germ cell neoplasms of sacrococcygeal region”. Cancer 20 (1967): 2105-2117.
- Tolins S H and Cooper P. “Presacral teratoma”. American Journal of Surgery 115 (1968): 734-737.
- Wilkinson J M., et al. “Obstructed defaecation because of adult sacrococcygeal teratoma”. Lancet 340 (1992): 1287-1288.
- Emoto, S., et al. “Surgical management for a huge presacral teratoma and a meningocele in an adult with Currarino triad: a case report”. Surgical Case Reports 4 (2018): 9.
- Simpson P J., et al. “Surgical outcomes in adults with benign and malignant sacrococcygeal teratoma: a single-institution experience of 26 cases”. Diseases of the Colon and Rectum 57 (2014): 851-857.
- Al-Essa AA., et al. “Adult sacrococcygeal teratomas”. Saudi Medical Journal 25 (2004): 367-369.
- Audet I M., et al. “Adult sacrococcygeal teratomas”. American Surgery 66 (2000): 61-65.
- Moreno-Fernández, J., et al. “Corticotrophin-dependent Cushing syndrome due to Sacrococcygeal Teratoma detected by [18F]fluorodeoxyglucose positron emission tomography”. The Journal of Clinical Endocrinology and Metabolism 93 (2008): 3282-3283.
- Killen D A and Jackson LM. “Sacrococcygeal teratoma in the adult”. Archives of Surgery 88 (1964): 425-433.
- Pye G and Blundell J W. “Sacrococcygeal teratoma masquerading as fistula-in-ano”. Journal of the Royal Society of Medicine 80 (1987): 251-252.
- Jucá M., et al. “Sacrococcycygeal teratoma in adult: report of a case”. International Journal of Gastrointestinal Cancer 37 (2006): 91-93.
- Tsutsui A., et al. “Successful laparoscopic resection of a sacrococcygeal teratoma in an adult: report of a case”. Surgery Today 41 (2011): 572-575.
- Woodward P J., et al. “From the archives of the AFIP: a comprehensive review of fetal tumors with pathologic correlation”. Radiographics 25 (2005): 215-242.
- Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition. Scholarly Editions, (2012).
- Pendlimari R., et al. “Rare malignant neuroendocrine transformation of a presacral teratoma in patient with Currarino syndrome”. International Journal of Colorectal Disease 25 (2010): 1383-1384.
- Tjalma W A A. “The value of AFP in congenital cervical teratoma”. Journal of Pediatric Surgery 38 (2003): 1846.
- Chen C., et al. “[Diagnostic value of multiple tumor marker detection for mature and immature teratoma of the ovary]”. Ai Zheng 27 (2008): 92-95.
- Mindaye E T., et al. “Adult case of giant sacrococcygeal teratoma: case report”. BMC Surgery 20 (2020): 295.
- Wishnia SC., et al. “Management of a presacral teratoma in an adult”. Journal of Clinical Oncology 26 (2008): 2586-2589.