Pharmacotherapeutic Effects of
Hippophae rhamnoides in Rat Model of Post-traumatic Epilepsy in View of Oxidative Stress, Na+,K+ATPase Activity and Sodium Ion Channel Expression
Stanzin Ladol 1,2* and Deepak Sharma 2
1Department of Zoology, Central University of Jammu, Bagla (Rahya Suchani) Distt. Samba, Jammu and Kashmir, India
2Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, New Delhi, India
*Corresponding Author: Stanzin Ladol, Department of Zoology, Central University of Jammu, Bagla (Rahya Suchani) Distt. Samba, Jammu and Kashmir, India.
March 11, 2021; Published: May 07, 2021
Background: Post-traumatic epilepsy (PTE) is a brain disorder characterized by an occurrence of spontaneous and recurrent seizures post brain insults. Initiation and progression of epilepsy is a complex process involving numerous cellular, molecular, and signalling mechanisms. Therefore, understanding the mechanism involved and finding safer treatments is of paramount importance.
Objectives and Methods: In this study, the antiepileptic effect of Hippophae rhamnoides (sea buckthorn/sbt) in post-traumatic epilepsy model was assessed. Post-traumatic epilepsy was induced by intracortical iron (5μl of 100mM FeCl 3) injection. Hippophae rhamnoides berry extract was administered orally at a dose of 1ml/kg b.wt. for 1 month. Then, the effect of sbt on the oxidative stress, Na +,K +ATPase activity and sodium ion channel expression was evaluated.
Results and Discussions: In cortex and hippocampus of epileptic rats, the results demonstrate altered electrophysiology, elevated oxidative stress, and reduced antioxidant defense. Additionally, reduced Na +,K +ATPase activity and elevated sodium channel Na v1.1 and Na v1.6 expression were also observed. Sbt administration has attenuated epileptiform activity, counteracted oxidative stress, elevated Na +,K +ATPase activity, and decreased sodium channel expression in the cortex and hippocampus of epileptic rats. In summary, our results demonstrate the antiepileptic effect of sbt that have possibly exerted by its antioxidative and ion channel regulatory properties in post-traumatic epilepsy model.
Keywords: Post-traumatic Epilepsy; Iron-induced Epilepsy; Hippophae rhamnoides; Sea Buckthorn; Seizure References
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