Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Research Article Volume 3 Issue 11

10,000-fold Effect by a Nitric Oxide Donor (Sodium Nitroprusside) in Parkinsonism Via Intrathecal Superfusion

Vinod Kumar Tewari1*, Neeraj Seth2, Devesh Johari3 and Lori Tewari4

1Neurosurgeon, Director, Advance Neuro and General Hospital, Lucknow, India
2Physiotherapist, Advance Neuro and General Hospital, Lucknow, India
3Opthalmologist, PMS, Jodhpur, Rajasthan, India
4Advance Neuro and General Hospital, Lucknow, India

*Corresponding Author: Vinod Kumar Tewari, Neurosurgeon, Director, Advance Neuro and General Hospital, Lucknow, India.

Received: October 09, 2020; Published: November 20, 2020

×

Abstract

Parkinsonism is a slow but nonfatal neurodegenerative disease characterized by hypokinesia, rigidity, postural instability and tremors, due to low quantity or deficient in dopamine neurotransmitter at Substantia Nigra, parkinsonism develops in, may be because of toxins, head injury or infections or drugs. Dopamine release is also regulated by NO (Nitric Oxide) which is generated by nitric oxide synthase (NOS) and NO acts via 10000-fold effect to reverse the neuronal parkinsonism clinical features. We have used intracarotid and intrathecal sodium nitroprusside to activate the 10000-fold effect to modulate the retrograde neuroregulation in Parkinsonism as a pilot study. The postural instability vanishes completely in 24 hours, loss of tremors was in just 48 hours, loss of rigidity around 5 days and hypokinesia improvement (to 75%) more than 30 days.

Keywords: Parkinsonism; 10000-fold Effect; Intrathecal Sodium Nitroprusside

×

References

  1. E LKoci., et al. “Molsidomine, a nitric oxide donor, modulates rotational behavior and monoamine metabolism in 6-OHDA lesioned rats treated chronically with L-DOPA”. Neurochemistry International8 (2013): 790-804.
  2. K Aqulano., et al. “Role of nitric oxide synthases in Parkinson's disease: a review on the antioxidant and anti-inflammatory activity of polyphenols”. Neurochemical Research12 (2008): 2416-2426.
  3. V K Tewari., et al. “Intracarotid Sodium Nitroprusside on Fifth Post Ischemic Stroke Day in Middle Cerebral Artery Occlusion Rat Model”. Journal of Clinical and Diagnostic Research 8 (2017): AF01-AF04.
  4. V Kumar., et al. “The 10,000-Fold Effect of Retrograde Neurotransmission, a New Concept for Stroke Revival: Use of Intracarotid Sodium Nitroprusside”. Journal of Evolution of Medical and Dental Sciences21 (2014): 5785-5803.
  5. Abboud H., et al. “Essential tremor: choosing the right management plan for your patient”. Cleveland Clinic Journal of Medicine12 (2011):  821-828.
  6. Lopez BM., et al. “Nitric oxide facilitates GABAergic neurotransmission in the cat oculomotor system: a physiological mechanism in eye movement control”. Journal of Physiology 540 (2002): 295-306.
  7. Ludovoc T and Tania V. “Neuronal nitric oxide synthase expressing neurons: a journey from birth to neuronal circuits”. Frontiers in Neural Circuits (2012).
  8. Lynn B. “Cavion Announces Promising Phase 2 Data for Essential Tremor in T-CALM Proof-of-Concept Study”. Lynn.blenkhorn@ogilvy.com. 508-851-0930. Or. Susan Klees, susanofcville@gmail.com. (434) 466-8930.
  9. Sergei G Kruglik., et al. “Picosecond primary structural transition of the heme is retarded after nitric oxide binding to heme proteins”. PNAS31 (2010) 13678-13683.
  10. L Wang., et al. “SPECT Molecular Imaging in Parkinson's Disease”. Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology (2012): 11.
  11. A Antonini and R DeNotaris. “PET and SPECT functioning imaging in Parkinson’s disease”. Sleep Medicine2 (2004):  201-206.
×

Citation

Citation: Vinod Kumar Tewari., et al. “10,000-fold Effect by a Nitric Oxide Donor (Sodium Nitroprusside) in Parkinsonism Via Intrathecal Superfusion”. Acta Scientific Neurology 3.11 (2020): 39-41.




Metrics

Acceptance rate32%
Acceptance to publication20-30 days

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is December 25, 2024.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of "Best Article of the Issue"

Contact US