Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Research Article Volume 3 Issue 11

10,000-fold Effect by a Nitric Oxide Donor (Sodium Nitroprusside) in Parkinsonism Via Intrathecal Superfusion

Vinod Kumar Tewari1*, Neeraj Seth2, Devesh Johari3 and Lori Tewari4

1Neurosurgeon, Director, Advance Neuro and General Hospital, Lucknow, India
2Physiotherapist, Advance Neuro and General Hospital, Lucknow, India
3Opthalmologist, PMS, Jodhpur, Rajasthan, India
4Advance Neuro and General Hospital, Lucknow, India

*Corresponding Author: Vinod Kumar Tewari, Neurosurgeon, Director, Advance Neuro and General Hospital, Lucknow, India.

Received: October 09, 2020; Published: November 20, 2020



Parkinsonism is a slow but nonfatal neurodegenerative disease characterized by hypokinesia, rigidity, postural instability and tremors, due to low quantity or deficient in dopamine neurotransmitter at Substantia Nigra, parkinsonism develops in, may be because of toxins, head injury or infections or drugs. Dopamine release is also regulated by NO (Nitric Oxide) which is generated by nitric oxide synthase (NOS) and NO acts via 10000-fold effect to reverse the neuronal parkinsonism clinical features. We have used intracarotid and intrathecal sodium nitroprusside to activate the 10000-fold effect to modulate the retrograde neuroregulation in Parkinsonism as a pilot study. The postural instability vanishes completely in 24 hours, loss of tremors was in just 48 hours, loss of rigidity around 5 days and hypokinesia improvement (to 75%) more than 30 days.

Keywords: Parkinsonism; 10000-fold Effect; Intrathecal Sodium Nitroprusside



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Citation: Vinod Kumar Tewari., et al. “10,000-fold Effect by a Nitric Oxide Donor (Sodium Nitroprusside) in Parkinsonism Via Intrathecal Superfusion”. Acta Scientific Neurology 3.11 (2020): 39-41.


Acceptance rate32%
Acceptance to publication20-30 days

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