Abstract

Parkinsonism is a slow but nonfatal neurodegenerative disease characterized by hypokinesia, rigidity, postural instability and tremors, due to low quantity or deficient in dopamine neurotransmitter at Substantia Nigra, parkinsonism develops in, may be because of toxins, head injury or infections or drugs. Dopamine release is also regulated by NO (Nitric Oxide) which is generated by nitric oxide synthase (NOS) and NO acts via 10000-fold effect to reverse the neuronal parkinsonism clinical features. We have used intracarotid and intrathecal sodium nitroprusside to activate the 10000-fold effect to modulate the retrograde neuroregulation in Parkinsonism as a pilot study. The postural instability vanishes completely in 24 hours, loss of tremors was in just 48 hours, loss of rigidity around 5 days and hypokinesia improvement (to 75%) more than 30 days.

Keywords: Parkinsonism; 10000-fold Effect; Intrathecal Sodium Nitroprusside

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Citation

Citation: Vinod Kumar Tewari., et al. “10,000-fold Effect by a Nitric Oxide Donor (Sodium Nitroprusside) in Parkinsonism Via Intrathecal Superfusion”. Acta Scientific Neurology 3.11 (2020): 39-41.

Copyright

Copyright: © 2020 Vinod Kumar Tewari., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.