Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Case Report Volume 3 Issue 12

10,000-Fold Effect by a Nitric Oxide Donor (Sodium Nitroprusside) in Essential Tremor Via Intrathecal Superfusion

Vinod Kumar Tewari1*, Devesh Johari2, Lori Tewari3, Neeraj4, Rajeev Gupta5 and SD Mishra6

1Neurosurgeon, Director, Advance Neuro and General Hospital, Lucknow, India
2Opthalmologist, PMS, Jodhpur, Rajasthan, India
3Advance Neuro and General Hospital, Lucknow, India
4Physiotherapist, Advance Neuro and General Hospital, Lucknow, India
5General Surgeon, Sanjeevani Hoapital, Jagraon Punjab, India
6General Surgeon, Advance Neuro and General Hospital, Lucknow, India

*Corresponding Author: Vinod Kumar Tewari, Neurosurgeon, Director, Advance Neuro and General Hospital, Lucknow, India..

Received: October 03, 2020; Published: November 18, 2020

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Abstract

  Essential tremor (ET) is involuntary tremors at upper part of body specially. The pathological neural circuits of GABAergic neuron of cerebellar dentate nucleus, brain stem (locus ceruleans and inferior olives) and thalamus is involved causes tremulous activity within the cerebellothalamocortical circuits. Nitric oxide donors, like Sodium nitroprusside, modulates the antegrade neurotransmission via retrograde neuroregulation by 10000-fold effect. The GABAergic neurons are in turn controlled by the very sensitive 10,000-fold effect circuits via Nitric Oxide. We have utilised intrathecal sodium nitroprusside superfusion (ITSNP) to induce 10000-fold effect after 2 years of failed routine conservative treatment by oral drugs like gabapentin, topiramate, trihexiphenedyl, or other drugs recommended in one ET cases. We have utilised various clinical parameters like spiral drawing (T-CALM TEST) and video recordings of routine daily activities in pre ITSNP and post ITSNP phase.

Keywords: Essential Tremor; 10000-fold Effect; Intrathecal Sodium Nitroprusside

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References

  1. Abboud H., et al. “Essential tremor: choosing the right management plan for your patient”. Cleveland Clinic Journal of Medicine12 (2011): 821-828.
  2. Tewari VK., et al. “Acupuncture-like TENS (AL-TENS) as a Quantitative Measure for the Feasibility of Intrathecal Sodium Nitroprusside Superfusion in Paraplegics for Physiological Recovery—A Pilot Study (13 Cases)”. Journal of Spinal Surgery2 (2019): 44-48.
  3. Tewari VK., et al. “The 10,000-Fold-Effect-Retrograde Neurotransmission- A Newer Concept for Paraplegias Physiological Revival-Use of Intrathecal Sodium Nitroprusside”. Journal of Evolution of Medical and Dental Sciences26 (2014): 7270-7285.
  4. Vinod Kumar Tewari., et al. “Intracarotid Sodium Nitroprusside on Fifth Post Ischemic Stroke Day in Middle Cerebral Artery Occlusion Rat Model”. Journal of Clinical and Diagnostic Research8 (2017): AF01-AF04.
  5. Lopez BM., et al. “Nitric oxide facilitates GABAergic neurotransmission in the cat oculomotor system: a physiological mechanism in eye movement control”. Journal of Physiology 540 (2002): 295-306.
  6. Ludovoc T and Tania V. “Neuronal nitric oxide synthase expressing neurons: a journey from birth to neuronal circuits”. Frontiers in Neural Circuits (2012).
  7. Lynn B Cavion. Announces Promising Phase 2 Data for Essential Tremor in T-CALM Proof-of-Concept Study. Lynn.blenkhorn@ogilvy.com. 508-851-0930. Or. Susan Klees, susanofcville@gmail.com. (434) 466-8930
  8. Sergei G Kruglik., et al. “Picosecond primary structural transition of the heme is retarded after nitric oxide binding to heme proteins”. Proceedings of the National Academy of Sciences of the United States of America31 (2010): 13678-13683.
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Citation

Citation: Vinod Kumar Tewari., et al. “10,000-Fold Effect by a Nitric Oxide Donor (Sodium Nitroprusside) in Essential Tremor Via Intrathecal Superfusion". Acta Scientific Neurology 3.12 (2020): 09-12.




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Acceptance rate32%
Acceptance to publication20-30 days
Impact Factor0.844

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