Abstract

  Essential tremor (ET) is involuntary tremors at upper part of body specially. The pathological neural circuits of GABAergic neuron of cerebellar dentate nucleus, brain stem (locus ceruleans and inferior olives) and thalamus is involved causes tremulous activity within the cerebellothalamocortical circuits. Nitric oxide donors, like Sodium nitroprusside, modulates the antegrade neurotransmission via retrograde neuroregulation by 10000-fold effect. The GABAergic neurons are in turn controlled by the very sensitive 10,000-fold effect circuits via Nitric Oxide. We have utilised intrathecal sodium nitroprusside superfusion (ITSNP) to induce 10000-fold effect after 2 years of failed routine conservative treatment by oral drugs like gabapentin, topiramate, trihexiphenedyl, or other drugs recommended in one ET cases. We have utilised various clinical parameters like spiral drawing (T-CALM TEST) and video recordings of routine daily activities in pre ITSNP and post ITSNP phase.

Keywords: Essential Tremor; 10000-fold Effect; Intrathecal Sodium Nitroprusside

References

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Citation

Citation: Vinod Kumar Tewari., et al. “10,000-Fold Effect by a Nitric Oxide Donor (Sodium Nitroprusside) in Essential Tremor Via Intrathecal Superfusion". Acta Scientific Neurology 3.12 (2020): 09-12.

Copyright

Copyright: © 2020 Vinod Kumar Tewari., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.