Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Research Article Volume 4 Issue 2

Sleep Disturbances and Association of Polymorphism rs2278749 Gene ARNTL in Male Population 25 - 44 Years in Russia/Siberia

Valery Gafarov1,2*, Elena Gromova1,2, Dmitriy Panov1,2, Igor Gagulin1,2, Almira Gafarova1,2 and Eldar Krymov1,2

1Collaborative Laboratory of Cardiovascular Diseases Epidemiology, Novosibirsk, Russia
2Institute of Internal and Preventive Medicine - Branch of Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia

*Corresponding Author: Valery Gafarov, Doctor of Sciences (Medicine), Professor, Head of Laboratory of Psychological and Sociological Issues of Internal Diseases, Institute of Internal and Preventive Medicine - Branch of Institute of Cytology and Genetics SB RAS, Head Collaborative laboratory of Cardiovascular Diseases Epidemiology, Novosibirsk, Russia.

Received: October 23, 2020; Published: November 18, 2020



  It was found that the most common genotype rs2278749 ARNTL gene was homozygous C/C genotype - 74,9%. Prevalence of C/T and T/T genotype was 22.3% and 2.8%, respectively. It was revealed that persons with the genotype C/T more likely to experience serious conflicts in the family, more experienced their frustration, they often have disturbing dreams, and they wake up tired and exhausted, in addition, they often met the high level of the life of exhaustion, and they soon became frustrated. Persons with genotype T/T often took the trouble "to heart" and were more punctual. On the other hand, persons with C/C genotype were more hostile, were inclined not to trust anyone, almost "never" accept negative situations "close to the heart" and much less experienced disturbing dreams.

Keywords: The ARNTL Gene; Genetic Polymorphism; rs2278749; Sleep Disorders; Psychosocial Factors



  1. Murray C and Lopez A. “The Global Burden of Disease”. Harvard University Press; Cambridge (1996).
  2. Partonen T and Magnusson A. “Seasonal Affective Disorder”. Oxford University Press; Oxford (2001).
  3. Benca RM., et al. “Sleep and psychiatric disorders. A meta-analysis”. Archives of General Psychiatry 49 (1992): 651-668.
  4. Gjessing R. “Contribution to the Somatology of Periodic Catatonia”. Pergamon; Oxford (1976).
  5. Dunlap JC. “Molecular bases for circadian clocks”. Cell 96 (1999): 271-290.
  6. Albrecht U and Eichele G. “The mammalian circadian clock”. Current Opinion in Genetics and Development 13 (2003): 271-277.
  7. Hirota T and Fukada Y. “Resetting mechanism of central and peripheral circadian clocks in mammals”. Zoology Science 21 (2004): 359-368.
  8. Hosoda H., et al. “A BMAL1 mutant with arginine 91 substituted with alanine acts as a dominant negative inhibitor”. Gene 338 (2004): 235-241.
  9. Li JZ., et al. “Circadian patterns of gene expression in the human brain and disruption in major depressive disorder”. Neuroscience PNAS24 (2013): 9950-9955.
  10. Jenkins CD., et al. “A scale for the estimation of sleep problems in clinical research”. Journal of Clinical Epidemiology 41 (1988): 313-321.
  11. WHO MONICA psychosocial optional study. Suggested measurement instruments. Copenhagen: World Health Organization (1988).
  12. WHO MONICA Project prepared by Kuulasmaa K. et al. Baseline population survey data book. MONICA Memo 178 A: Helsinki (1990).
  13. Bühl A., et al. “Einführung in die moderne Datenanalyse unter Windows” (2005).
  14. Epi Info 7 is public domain statistical software for epidemiology developed by Centers for Disease Control and Prevention (CDC) in Atlanta, Georgia (USA).
  15. Wellcome Trust Case Control Consortium. “Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls”. Nature7145 (2007): 661-678.


Citation: Valery Gafarov., et al. “Sleep Disturbances and Association of Polymorphism rs2278749 Gene ARNTL in Male Population 25 - 44 Years in Russia/Siberia". Acta Scientific Neurology 4.2 (2021): 02-08.


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