Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Review Article Volume 3 Issue 11

Nutritional Epigenetic Support for Fighting Viral and Toxin Exposure

Jennifer Gantzer*

Clinical Sciences Department, National University of Health Sciences, USA

*Corresponding Author: Jennifer Gantzer, Clinical Sciences Department, National University of Health Sciences, USA.

Received: October 01, 2020; Published: October 22, 2020

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Abstract

  Extrinsic epigenetic influences alter the physiological function and body habitus response to transient as well as long-term exposures and more importantly, the outcome of the response. We must prepare nutritionally and epigenetically to sustain and support optimal function which then allows the body’s intrinsic mechanisms to do their job, including fighting foreign invaders (i.e. bacteria, virus, parasite, fungus) and eliminating toxins (i.e. chemicals, pollutants, xenobiotic medications and OTC drugs, heavy metals, volatile gases) each requiring bioavailable essential nutrients that power and support enzymatic reactions that are the physiological machinery behind these immune and toxic battles.

Keywords: Nutritional Epigenetics; Inflammation; Oxidative Stress; Antioxidants; Liver Detox Pathway; Toxin Burden; NFkB, Nrf2

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References

  1. Cecchini R and Cecchini AL. “SARS-CoV-2 infection pathogenesis is related to oxidative stress as a response to aggression”. Medical Hypotheses 143 (2020): 110102.
  2. Kumar V., et al. “Robbins and Cotran pathologic basis of disease (Ninth edition.)”. Philadelphia, PA: Elsevier/Saunders (2015).
  3. Bogdan C. “Oxidative burst without phagocytes: the role of respiratory proteins”. Nature Immunology 8 (2007): 1029-1031.
  4. Paiva CN and Bozza MT. “Are reactive oxygen species always detrimental to pathogens?”. Antioxid Redox Signal6 (2014): 1000-1037.
  5. Lai CC., et al. “Co-infections among patients with COVID-19: The need for combination therapy with non-anti-SARS-CoV-2 agents?”. Journal of Microbiology, Immunology and Infection 4 (2020): 505-512.
  6. Gropper Sareen S. “Advanced Nutrition and Human Metabolism”. Wadsworth Publishing. Kindle Edition.
  7. Colitti M., et al. “Oxidative Stress and Nutraceuticals in the Modulation of the Immune Function: Current Knowledge in Animals of Veterinary Interest”. Antioxidants 1 (2019): 28.
  8. Betteridge DJ. “What is oxidative stress?” Metabolism2-1 (2000): 3-8.
  9. Cui JY and Li CY. “Textbook of Toxicology”. Chapter 2.08 Regulation of Xenobiotic Metabolism in the Liver”. University of Washington, Elsevier: Seattle (2018).
  10. Croom E. “Metabolism of xenobiotics of human environments”. Progress in Molecular Biology and Translational Science 112 (2012): 31-88.
  11. Patterson R and Sears D. “Metabolic Effects of Intermittent Fasting”. Annual Review of Nutrition 1 (2017): 371-393.
  12. Woods JA., et al. “Exercise, inflammation and aging”. Aging and Disease 1 (2012): 130-140.
  13. Mullington JM., et al. “Sleep loss and inflammation”. Best Practice and Research Clinical Endocrinology and Metabolism 5 (2010): 775-784.
  14. Kubota T. “Epigenetic alterations induced by environmental stress associated with metabolic and neurodevelopmental disorders”. Environmental Epigenetics 3 (2016): dvw017.
  15. Cunliffe VT. “The epigenetic impacts of social stress: how does social adversity become biologically embedded?”. Epigenomics12 (2016): 1653-1669.
  16. Moosavi A and Motevalizadeh Ardekani A. “Role of Epigenetics in Biology and Human Diseases”. Iranian Biomedical Journal 5 (2016): 246-258.
  17. Lawrence T. “The nuclear factor NF-kappaB pathway in inflammation”. Cold Spring Harbor Perspectives in Biology 6 (2009): a001651.
  18. Ting Liu., et al. “NF-κB signaling in inflammation”. Signal Transduction and Targeted Therapy – Nature 2 (2017): 17023.
  19. Maroon JC., et al. “Natural anti-inflammatory agents for pain relief”. Surgical Neurology International 1 (2010): 80.
  20. Gantzer J. “eNOS and BH4; endothelial function or dysfunction. Importance of tetrahydrobiopterin (BH4)”. Journal of Neurology and Clinical Neuroscience 3 (2018).
  21. Colitti M., et al. “Oxidative Stress and Nutraceuticals in the Modulation of the Immune Function: Current Knowledge in Animals of Veterinary Interest”. Antioxidants1 (2019): 28.
  22. Betteridge DJ. “What is oxidative stress?” Metabolism2-1 (2000): 3-8.
  23. Sun Y., et al. “Preventive and Protective Roles of Dietary Nrf2 Activators Against Central Nervous System Diseases”. CNS and Neurological Disorders - Drug Targets 3 (2017): 326-338.
  24. Guilliams T. “Functional Strategies for the Management of Gastrointestinal Disorders”. Point Institute, Wisconsin (2016).
  25. Jandacek RJ and Tso P. “Factors affecting the storage and excretion of toxic lipophilic xenobiotics”. Lipids12 (2001): 1289-1305.
  26. Traber MG and Stevens JF. “Vitamins C and E: beneficial effects from a mechanistic perspective”. Free Radical Biology and Medicine 5 (2011): 1000-1013.
  27. Ang A., et al. “Vitamin C and immune cell function in inflammation and cancer”. Biochemical Society Transactions 5 (2018): 1147-1159.
  28. Brossaud J., et al. “Vitamin A, endocrine tissues and hormones: interplay and interactions”. Endocrine Connections 7 (2017): R121-R130.
  29. Ma F., et al. “Retinoid X receptor α attenuates host antiviral response by suppressing type I interferon”. Nature Communications 5 (2014): 5494.
  30. Vazquez A. “Functional Immunological and Nutritional Immunomodulation”. Portland, OR: Integrative and Biological Medicine Research and Consulting, LLC (2012).
  31. Lin R. “Crosstalk between Vitamin D Metabolism, VDR Signalling, and Innate Immunity”. BioMed Research International (2016): 1375858.
  32. Fürst P. “Basics in clinical nutrition: Proteins and amino acids”. European e-Journal of Clinical Nutrition and Metabolism 2 (2008): e62-e65.
  33. Park MH and Hong JT. “Roles of NF-κB in Cancer and Inflammatory Diseases and Their Therapeutic Approaches”. Cells 2 (2016): 15.
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Citation

Citation: Jennifer Gantzer. “Nutritional Epigenetic Support for Fighting Viral and Toxin Exposure". Acta Scientific Neurology 3.11 (2020): 80-84.




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