Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Case Study Volume 3 Issue 11

A Clinicopathological Correlation of Pineal Region Tumours

Prabal Deb1 and Gurpreet Kaur2*

1Director Operations and Chief Histopathologist SRL Diagnostics, India
2Department of Hematopathology, All India Institute of Medical Sciences, India

*Corresponding Author: Gurpreet Kaur, Senior Resident, Department of Hematopathology, All India Institute of Medical Sciences, New Delhi, India.

Received: September 16, 2020; Published: October 15, 2020



  A variety of lesions involve the pineal region these include both neoplastic processes and congenital le¬sions. Tumors of the pineal region are classified into those arising from the pineal parenchyma, germ cell neoplasms, metastasis, and lesions aris¬ing from adjacent structures. They make up less than 1% of intracranial tumors in adults and are commoner in children. Knowledge of the variety of lesions that occur in the pineal region, their imaging ap¬pearances, and their clinical features assists in narrowing the differential diagnosis and optimizing patient treatment of these rare tumors. Pineal gland lesions as it is are rare, with only a few cytologic descriptions occurring in the literature. We hereby present 04 cases of pineal region tumours with a radiology cytology and histopathological correlation.

Keywords: Pineal Gland; Cytology; Pineoblastoma; Pineocytoma; Germinoma



  1. Jouvet A., et al. "Pineal parenchymal tumours and pineal cysts”. Neurochirurgie2-3 (2015): 123-129.
  2. Ostrom Quinn T., et al. "CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2009–2013”. Neuro-oncology5 (2016): 1-75.
  3. Villano J Lee, et al. "Malignant pineal germ-cell tumors: an analysis of cases from three tumor registries”. Neuro-oncology2 (2008): 121-130.
  4. Osborn AG., et al. "The new World Health Organization classification of central nervous system tumors: what can the neuroradiologist really say?”. American Journal of Neuroradiology5 (2012): 795-802. 
  5. Fèvre‐Montange M., et al. "Utility of Ki67 immunostaining in the grading of pineal parenchymal tumours: a multicentre study”. Neuropathology and Applied Neurobiology1 (2012): 87-94.
  6. Jouvet Anne., et al. "Pineal parenchymal tumors: a correlation of histological features with prognosis in 66 cases”. Brain Pathology1 (2000): 49-60.
  7. Sugiyama K., et al. Intracranial germ-cell tumor with synchronous lesions in the pineal and suprasellar regions: report of six cases and review of the literature”. Surgery in Neurology2 (1992): 114-121.
  8. Nagasawa Daniel T., et al. "Pineal germ cell tumors: two cases with review of histopathologies and biomarkers”. Journal of Clinical Neuroscience38 (2017): 23-31.
  9. Schild Steven E., et al. "Pineal parenchymal tumors: clinical, pathologic, and therapeutic aspects”. Cancer3 (1993): 870-880.
  10. De Girolami U., et al. "Pathology of tumors of the pineal region”. Revue Neurologique11 (2008): 882-895.
  11. Villa Salvador., et al. "Primary pineal tumors: outcome and prognostic factors—a study from the Rare Cancer Network (RCN)”. Clinical and Translational Oncology11 (2012): 827-834.
  12. Schild Steven E., et al. "Histologically confirmed pineal tumors and other germ cell tumors of the brain”. Cancer: Interdisciplinary International Journal of the American Cancer Society12 (1996): 2564-2571.


Citation: Prabal Deb and Gurpreet Kaur. “A Clinicopathological Correlation of Pineal Region Tumours". Acta Scientific Neurology 3.11 (2020): 20-25.


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