Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Opinion Volume 3 Issue 10

The Role of Cytokins in Some Viral Infectious Diseases

Shimon Shatzmiller*, Galina Zats, Inbal Lapidot and Rami Krieger

Department of Biological Chemistry, Ariel University, Arieel, Israel

*Corresponding Author: Shimon Shatzmiller, Department of Biological Chemistry, Ariel University, Arieel, Israel.

Received: July 25, 2020; Published: September 30, 2020

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  Cytokines are small glycoproteins produced by several cell types, mainly leukocytes, which regulate immunity, inflammation and hematopoiesis. They control several physiological and pathological roles, including innate immunity, acquired protection, and an abundance of inflammatory responses. The research of cytokines starts in the 1950s. However, the exact identification of the structure and its function took many years to explore. The original findings were those of IL-I, IFN, and neurodevelopment factors (NGFs); However, these cytokines were purified and transferred in their name years later. Research of the exact physiological, pathological and pharmacological effects of some cytokines is still in progress. For example: Neurotrophins are a family of proteins that induce the survival, development, and function of neurons [NGF, BDNF, neurotropin-3 (NT-3) and NT4/5] are secreted proteins that have a strong effect on the neural nerve Survival, differentiation, and synaptic function. Adult neurotrophins bind better to Trans-kinanic (Trk) and p75 NTR, whereas proneurotropins, which contain a proteolytic N-terminal region Removed in "mature" forms, communicates with p75 NTR and through it Their N-terminal domains, with sorting receptor sorting. The p75 NTR interacts with Trks and regulates the Trk signals But it is also independently integrated into various probiotic and prooptotic signaling systems.

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References

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Citation

Citation: Shimon Shatzmiller., et al. “The Role of Cytokins in Some Viral Infectious DiseasesThe Role of Cytokins in Some Viral Infectious Diseases". Acta Scientific Neurology 3.10 (2020): 69-71.




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