Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Case Report Volume 3 Issue 10

10,000-Fold Effect by a Nitric Oxide Donor (Sodium Nitroprusside) in Motor Neuron Disease Via Intrathecal Superfusion

Vinod Kumar Tewari1*, Neeraj2, Devesh Johari3 and Lori Tewari4

1Director, Advance Neuro and General Hospital, Arjunaganj, Lucknow, UP, India
2Physiotherapist, Advance Neuro and General Hospital, Arjunaganj, Lucknow, UP, India
3Ophthalmologist, Advance Neuro and General Hospital, Arjunaganj, Lucknow, UP, India
4Advance Neuro and General Hospital, Arjunaganj, Lucknow, UP, India

*Corresponding Author: Vinod Kumar Tewari, Director, Advance Neuro and General Hospital, Arjunaganj, Lucknow, UP, India.

Received: August 03,2020; Published: September 24, 2020

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Abstract

  Motor Neuron Disease (MND) or Amyotrophic lateral sclerosis (ALS) is a slow fatal neurodegenerative disease characterized by selective and gradual motor neuronal death with unknown aetiology. The insufficient clearance of glutamate through the glutamate transporter and the specific distribution of Ca2+-permeable AMPA receptors in spinal motor neurons, indicates that glutamate-induced neurotoxicity is involved in its pathogenesis. NO is generated by nitric oxide synthase (NOS) which acts via 10000-fold effect to reverse the neuronal death. NO is destructive within 5 to 7 days as noted in earlier study by various authors. We have used intrathecal sodium nitroprusside to activate the 10000-fold effect to modulate the retrograde neuroregulation in MND.

Keywords: Motor Neuron Disease; Amyotrophic Disease; 10000-Fold Effect; Intrathecal Sodium Nitroprusside

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Citation

Citation: Vinod Kumar Tewari., et al. “10,000-Fold Effect by a Nitric Oxide Donor (Sodium Nitroprusside) in Motor Neuron Disease Via Intrathecal Superfusion". Acta Scientific Neurology 3.10 (2020): 24-28.




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