Abstract

  Motor Neuron Disease (MND) or Amyotrophic lateral sclerosis (ALS) is a slow fatal neurodegenerative disease characterized by selective and gradual motor neuronal death with unknown aetiology. The insufficient clearance of glutamate through the glutamate transporter and the specific distribution of Ca2+-permeable AMPA receptors in spinal motor neurons, indicates that glutamate-induced neurotoxicity is involved in its pathogenesis. NO is generated by nitric oxide synthase (NOS) which acts via 10000-fold effect to reverse the neuronal death. NO is destructive within 5 to 7 days as noted in earlier study by various authors. We have used intrathecal sodium nitroprusside to activate the 10000-fold effect to modulate the retrograde neuroregulation in MND.

Keywords: Motor Neuron Disease; Amyotrophic Disease; 10000-Fold Effect; Intrathecal Sodium Nitroprusside

References

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Citation

Citation: Vinod Kumar Tewari., et al. “10,000-Fold Effect by a Nitric Oxide Donor (Sodium Nitroprusside) in Motor Neuron Disease Via Intrathecal Superfusion". Acta Scientific Neurology 3.10 (2020): 24-28.

Copyright

Copyright: © 2020 Vinod Kumar Tewari., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.