Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Case Report Volume 3 Issue 9

Concomitant Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Myasthenia Gravis-A Two-Case Report

Nan Jiang* and Mohamed Kazamel

Division of Neuromuscular Disease, Department of Neurology, The University of Alabama at Birmingham, Birmingham, Alabama, United States of America

*Corresponding Author: Nan Jiang, Division of Neuromuscular Disease, Department of Neurology, The University of Alabama at Birmingham, Birmingham, Alabama, United States of America.

Received: August 12, 2020; Published: August 31, 2020

×

Abstract

  Few cases of co-existing chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) and seropositive myasthenia gravis (MG) were reported. However, there is no reports on co-existence of CIDP with seronegative MG or on the responses to treatment of both diseases. We report two cases with diagnosis of CIDP and MG. The first case is 38-year-old African American female with initial diagnosis of CIDP and later onset bulbar symptoms. She was diagnosed with seronegative MG by clinical suspicion and single fiber electromyography (SFEMG). The other case is a 65-year-old British male who initially diagnosed as seropositive MG then he developed paresthesia and difficult walking a few months later. CIDP was confirmed by electrodiagnostic study and albuminocytologic dissociation in cerebrospinal fluid analysis. The first case underscores the importance of performing SFEMG on cranial muscles in cases of CIDP with cranial nerve involvement even if serological testing for MG is negative. In both cases, bulbar symptoms were more responsive to immunomodulatory treatment than limb symptoms.

Keywords: Chronic Inflammatory Demyelinating Polyradiculoneuropathy; Immunomodulatory Treatment; Myasthenia Gravis; Single Fiber EMG; Treatment Response

×

Citation

Citation: Nan Jiang and Mohamed Kazamel. “Concomitant Chronic Inflammatory Demyelinating Polyradiculoneuropathy and Myasthenia Gravis-A Two-Case Report". Acta Scientific Neurology 3.9 (2020): 117-120.




Metrics

Acceptance rate32%
Acceptance to publication20-30 days
Impact Factor0.844

Indexed In




News and Events


  • Certification for Review
    Acta Scientific certifies the Editors/reviewers for their review done towards the assigned articles of the respective journals.
  • Submission Timeline for Upcoming Issue
    The last date for submission of articles for regular Issues is March 10, 2021.
  • Publication Certificate
    Authors will be issued a "Publication Certificate" as a mark of appreciation for publishing their work.
  • Best Article of the Issue
    The Editors will elect one Best Article after each issue release. The authors of this article will be provided with a certificate of “Best Article of the Issue”.
  • Welcoming Article Submission
    Acta Scientific delightfully welcomes active researchers for submission of articles towards the upcoming issue of respective journals.
  • Contact US