Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Case Report Volume 3 Issue 9

10,000-fold Effect by a Nitric Oxide Donor (Sodium Nitroprusside) in Duchenne Muscular Dystrophy (DMD) Via Intrathecal Superfusion and Oral Tadalafil - A Case Report

Vinod Kumar Tewari1*, Neeraj2, Devesh Johari3 and Lori Tewari4

1Director, Advance Neuro and General Hospital, Arjunaganj, Lucknow, UP, India
2Physiotherapist, Advance Neuro and General Hospital, Arjunaganj, Lucknow, UP, India
3Ophthalmologist, Advance Neuro and General Hospital, Arjunaganj, Lucknow, UP, India
4Advance Neuro and General Hospital, Arjunaganj, Lucknow, UP, India

*Corresponding Author: Vinod Kumar Tewari, Director, Advance Neuro and General Hospital, Arjunaganj, Lucknow, UP, India.

Received: August 25, 2020; Published: August 31, 2020

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Abstract

  Duchenne Muscular Dystrophy (DMD) is a slow, progressive and fatal X-linked neuromuscular disorder due to loss of dystrophin that links the contractile apparatus to the sarcolemma via the dystrophin-associated protein complex (DPC).

  The NOD (Nitric Oxide Donor) causes release of Nitric Oxide (NO) by nitric oxide synthase (NOS) and then via 10,000-fold effect NOR (Nitric Oxide Receptor) it acts to release cGMP thus modulates DPC and improves the skeleton muscle functionality.

  We have used intrathecal sodium nitroprusside to activate the 10000-fold effect to modulate the retrograde neuroregulation in DMD (diagnosed by muscle biopsy) and oral Tadalafil as NODs and well checked by AL-TENS (acupuncture like transepidermal neural stimulation) in pre ITSNP and post ITSNP phase.

Keywords: Duchenne Muscular Dystrophy (DMD); 10000-fold Effect; Intrathecal Sodium Nitroprusside; Oral Tadalafil

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Citation

Citation: Vinod Kumar Tewari., et al. “10,000-fold Effect by a Nitric Oxide Donor (Sodium Nitroprusside) in Duchenne Muscular Dystrophy (DMD) Via Intrathecal Superfusion and Oral Tadalafil - A Case Report".Acta Scientific Neurology 3.9 (2020): 95-98.




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Acceptance rate32%
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Impact Factor0.844

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