Abstract

During the present pandemic of COVID-19 disease, interest has shifted from the respiratory system affectation to involvement of other organs and systems. Recently pre-eminence of neurological symptoms and signs has emerged. We have done a comprehensive review of the literature published as open access in various databases with the purpose of increasing our understanding of the disease and aid in the identification of patients with these neurological conditions. We have reviewed articles reporting neurologic manifestations in young individuals and children. Although there is nor enough data to establish prevalence of the conditions affecting pediatric population, as the number of worldwide cases increases we expect to find an increase in these reports. it is considered of utmost importance to urge clinicians to document symptoms and neurological signs in the context of the disease in order to contribute to a better understanding of Neurocovid and to generate a body of knowledge that influences the optimization of the diagnosis and approach of this entity, taking as a premise that the early installation of individualized and reasoned treatments will translate in a better survival rate of those affected and lower the occurrence of eventual ongoing deficits.

Keywords: COVID-19; Severe Acute Respiratory Syndrome (SAPS); Middle East Respiratory Syndrome (MERS)

References

1. Baltimore D. “Expression of animal virus genomes”. Bacteriology Review 35 (1971): 235-24.
2. Chan J., et al. “Genomic characterization of the 2019 novel human -pathogenic coronavirus isolated from a patient with atypical pneumonia after visiting Wuhan”. Emerging Microbes and Infections 28.9 (2020): 221-236.
3. Romero-Sánchez C., et al. “Neurologic Manifestations in hospitalized patients with COVID-19: The ALBACOVID registry”. Neurology (2020).
4. Vavougios G. “Potentially irreversible olfactory and gustatory impairments in Covid-19: Indolent versus Fulminant SARS-CoV-2 neuroinfection”. Brain, Behavior, and Immunity (2020).
5. Mao L., et al. “Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study”. Lancet Neurology (2020).
6. Bertran-Recasens B., et al. “Lack of dyspnea in Covid-19 patients another neurological conundrum?” European Journal of Neurology (2020). 
7. Zanin L., et al. “SARS-C0V-2 can induce brain and spine demyelinating lesions”. Acta Neurochirurgica 4 (2020): 1-4.
8. Moriguchi T., et al. “A first case of Meningitis/Encephalitis associated with SARS-Coronavirus-2”. International Journal of Infectious Diseases 94 (2020): 54-58.
9. Huang H., et al. “SARS-CoV-2 Detected in Cerebrospinal Fluid by PCR in a Case of COVID-19 Encephalitis”. Brain, Behavior, and Immunity 87 (2020): 149. 
10. Quin C., et al. “Dysregulation of immune response in patients with Covid-19 in Wuhan, China”. China (February 17,2020) (2020). 
11. Huang C., et al. “Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China”. The Lancet 395 (2020): 497-506.
12. Duong L., et al. “Meningoencephalitis without respiratory failure in a young female patient with Covid-19 infection in downtown Los Angeles, early April 2020”. Brain, Behavior, and Immunity 87 (2020): 33.
13. Varga Z., et al. “Endothelial cell infection and endothelitis in COVID 19”. Lancet 395.10234 (2020): 1417-1418. 
14. Kanberg N., et al. “Neurochemical evidence of astrocytic and neuronal in jury commonly found in COVID-19”. Neurology (2020).
15. Panciani P., et al. “SARS-CoV-2: “Three-steps” infection model and CSF diagnostic implication”. Brain, Behavior, and Immunity (2020). 
16. Fotuhi M., et al. “Neurobiology of COVID-19”. Journal of Alzheimer’s Disease (2020): 1-17.
17. Escalada-Pellitero S., et al. “Report of a patient with neurological symptoms as the sole manifestation of SARS-Cov-2 infection”. Madrid. Spain (2020).
18. Zhao H., et al. “Guillain Barre Syndrome associated with SARS-CoV-2 infection: Causality or coincidence?” Lancet Neurology 19.5 (2020): P383-384.
19. El Otmani H., et al. “Covid-19 and Guillain-Barré syndrome: More than a coincidence!”. Revue Neurologique 176 (2020): 516-525.
20. Chaumont H., et al. “Acute Meningoencephalitis in a patient with COVID-19”. Revue Neurologique 176 (2020): 516-525
21. Xiang P., et al. “First case of 2019 novel coronavirus disease with Encephalitis”. ChinaXiv (2020).
22. Xu Z., et al. “Pathological findings of COVID-19 associated with acute respiratory distress syndrome”. Lancet Respiratory Medicine 8.4 (2020): 420-422. 
23. Wu Y., et al. “Nervous system involvement after infection with COVID-19 and other Coronaviruses”. Brain Behavior and Immunity (2020).
24. Mehta P., et al. “COVID-19: consider cytokine storm syndromes and immunosuppression”. Lancet 395.10229 (2020): 1033-1034.
25. Reyes M., et al. “COVID-19 and D-dimer: Frequently asked questions”. COVID-19 Resources @hematology.org. American Society of Hematology (2020).
26. Hemasian H and Ansari B. “First case of Covid-19 presented with cerebral venous thrombosis: A rare and dreaded case”. Revue Neurologique 176 (2020) 516-525.
27. Baig A., et al. “Evidence of COVID-19 virus targeting the CNS: tissue distribution, host virus interactions, and proposed neurotropic mechanisms”. ACS Chemical Neuroscience 11.7 (2020): 995-998.
28. Vollono C., et al. “Focal Status epilepticus as a unique clinical feature of COVID/19: a case report”. Our Journal of Epilepsy (2020).
29. Filatov A., et al. “Neurological Complications of Corona virus Disease (COVID-19): Encephalopathy”. Cureus 12.3 (2020): e7352. 
30. Lu l., et al. “New onset acute symptomatic seizure and risk factors in coronavirus disease 2019: a multi center retrospective study”. Epilepsia 61.9 (2020): e49-e53.
31. Li Y., et al. “Coronavirus infections in the central nervous system and respiratory tract show distinct features in hospitalized children”. Intervirology 59 (2016): 163-169.
32. Yeh EA., et al. “Detection of Coronavirus in the Central Nervous System of a Child With Acute Disseminated Encephalomyelitis”. Pediatrics 113.1 (2004)e73-e76. 
33. Bunyavanich S., et al. “Nasal gene expression of angiotensin-converting enzyme 2 in children and adults”. JAMA 323.23 (2020): 2427-2449.
34. Dong Y., et al. “Epidemiological Characteristics of 2143 pediatric patients with 2019 coronavirus disease in China”. Pediatrics (2020): e20200702.
35. Qiu H., et al. “Clinical and epidemiological features of 36children with coronavirus disease 2019 (COVID-19) in Zhejiang, China: an observational cohort study”. The Lancet Infectious diseases 20 (2020): 689-696.
36. Vaira L., et al. “Anosmia and ageusia: common findings in COVID-19 patients”. Laryngoscope (2020). 
37. Abdel-Mannou O., et al. “Neurological and Radiographic Findings Associated with COVID-19 in Children”. JAMA Neurology (2020). 
38. Frontera J., et al. “Global Consortium Study of Neurological Dysfunction in COVID-19 (GCS-NeuroCOVID): Study Design and Rationale”. Neurocritical Care (2020): 1-10.
39. Neurocritical Care Society. “Covid-19 Manifestations in Pediatric Patients” (2020).

Citation

Citation: Maria Elena López and Sofia Isea. “COVID-19 and the Brain".Acta Scientific Neurology 3.9 (2020): 41-46.

Copyright

Copyright: © 2020 Maria Elena López and Sofia Isea. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.