Esther López-Bayghen1*, Karla Pérez-Toledo1,2, Leticia Ramírez- Martínez1, Jacqueline Robledo1, Vianney Ortiz3 and Arturo Ortega1
1Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del
IPN, Ciudad de México, México
2Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios
Avanzados del IPN, Ciudad de México, México
3Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios
Avanzados del IPN, Ciudad de México, México
*Corresponding Author: Esther López-Bayghen, Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del IPN, Ciudad de México, México.
Received: May 23, 2020; Published: June 08, 2020
The class-I MHC-restricted T-cell associated molecule (CRTAM), an activation molecule expressed in activated Natural Killer cells (NKT) and CD8+ T cells, is highly expressed in the cerebellar cortex, both in neurons and glial cells. During cerebellar development, granule cell migration over Bergmann glia cells depends on neuronal/glia glutamatergic signaling, suggesting a regulated cell-cell interaction process, opening the possibility of CTRAM and Nectin-like 2 involvement. Through the use of the well-established model of chicken cerebellar Bergmann glial cells and a wound/healing assay, we describe herein that glutamate represses CRTAM expression, enhancing migration. These results reveal an unexpected function of CTRAM in the cerebellum
Keywords: CRTAM; Nectin-Like 2; Cell Migration; Glutamate Receptors; Bergmann Glial Cells
Citation: Esther López-Bayghen., et al. “Class-I MHC-Restricted T-Cell Associated Molecule (CRTAM) Expression in Cerebellum".Acta Scientific Neurology 3.7 (2020): 03-11.
Copyright: © 2020 Esther López-Bayghen., et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.