Acta Scientific Neurology (ASNE) (ISSN: 2582-1121)

Review Article Volume 3 Issue 7

Class-I MHC-Restricted T-Cell Associated Molecule (CRTAM) Expression in Cerebellum

Esther López-Bayghen1*, Karla Pérez-Toledo1,2, Leticia Ramírez- Martínez1, Jacqueline Robledo1, Vianney Ortiz3 and Arturo Ortega1

1Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del IPN, Ciudad de México, México
2Departamento de Genética y Biología Molecular, Centro de Investigación y de Estudios Avanzados del IPN, Ciudad de México, México
3Departamento de Biomedicina Molecular, Centro de Investigación y de Estudios Avanzados del IPN, Ciudad de México, México

*Corresponding Author: Esther López-Bayghen, Departamento de Toxicología, Centro de Investigación y de Estudios Avanzados del IPN, Ciudad de México, México.

Received: May 23, 2020; Published: June 08, 2020

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Abstract

The class-I MHC-restricted T-cell associated molecule (CRTAM), an activation molecule expressed in activated Natural Killer cells (NKT) and CD8+ T cells, is highly expressed in the cerebellar cortex, both in neurons and glial cells. During cerebellar development, granule cell migration over Bergmann glia cells depends on neuronal/glia glutamatergic signaling, suggesting a regulated cell-cell interaction process, opening the possibility of CTRAM and Nectin-like 2 involvement. Through the use of the well-established model of chicken cerebellar Bergmann glial cells and a wound/healing assay, we describe herein that glutamate represses CRTAM expression, enhancing migration. These results reveal an unexpected function of CTRAM in the cerebellum

Keywords: CRTAM; Nectin-Like 2; Cell Migration; Glutamate Receptors; Bergmann Glial Cells

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References

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Citation

Citation: Esther López-Bayghen., et al. “Class-I MHC-Restricted T-Cell Associated Molecule (CRTAM) Expression in Cerebellum".Acta Scientific Neurology 3.7 (2020): 03-11.



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